Erythropoietin Reverses Sepsis-Induced Vasoplegia to Norepinephrine Through Preservation of {alpha}1D-Adrenoceptor mRNA Expression and Inhibition of GRK2-Mediated Desensitization in Mouse Aorta

In conclusion, EPO seems to reverse sepsis-induced vasoplegia to NE through the preservation of α1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Kandasamy, K., Choudhury, S., Singh, V., Addison, M. P., Darzi, S. A., Kasa, J. K., Thangamalai, R., Dash, J. R., Kumar, T., Sultan, F., Singh, T. U., Parida, S., Mishra, S. K. Tags: Experimental Studies Source Type: research