Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis

Conclusion: These findings suggest a role for epigenetic modifications in contributing to the profibrotic and hypertrophic changes evident during disease progression. Therapeutic intervention with 5-aza demonstrated favorable effects highlighting the potential use of this epigenetic modifier as a treatment option for cardiac pathologies associated with hypertrophy and fibrosis.

http://cpt.sagepub.com/cgi/content/abstract/21/1/127?rss=1

Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Watson, C. J., Horgan, S., Neary, R., Glezeva, N., Tea, I., Corrigan, N., McDonald, K., Ledwidge, M., Baugh, J. Tags: Experimental Studies Source Type: research