International Journal of Phytomedicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

 Phytochemical and pharmacological investigation of Teucrium muscatense 
The effect of enzyme inhibition, anticancer, antifungal, antioxidants activities of the extracts ofTeucrium muscatenseobtained with different organic solvents was investigated. Chloroform fraction exhibited promising inhibition (64%) with IC50value (390 ± 2.0 μg/mL) against urease, while other fractions displayed moderate activity. In case of α-glucosidase and acetyl cholinesterase enzyme inhibition assays, all fractions were found inactive at a concentration of 1.0 mg/mL. Then-hexane fraction ofTeucrium muscatenseexhibited highest anticancer activity against breast cancer cell (MDAMB231) line at high (100 µg/mL) conce...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Najeeb Ur Rehman Source Type: research

Effects of Opuntia ficus-indica flower extract WS 1261 on mental and psychic function in subsyndromal fatigue – A pilot study
ConclusionsA consistent and positive effect of Opuntia ficus-indica flowers extract on symptoms of fatigue could be demonstrated. Improvement in all mental and psychic functions could be measured, most of them statistically significant. (Source: International Journal of Phytomedicine)
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Gaby Kressel Source Type: research

Molecular genetic evaluation of Cichorium endivia L. as an anticancer agent against colorectal cancer
Medicinal plants confer protective effects against a wide range of cancers including colon cancer.Cichorium endivia L. has many biological activities and functions, such as anti-inflammation and hepatoprotective effects. This activity is mainly due to its high levels of antioxidant compounds. The effect of cichorium extract and fluorouracil (5-FU) against colorectal cancer (CRC) induced by 1, 2- Dimethyl hydrazine (DMH) was examined in male albino mice. Where, different doses of cichorium extract (200, 400 and 600 mg/kg body weight) were investigated to determine the significant effective dose against colorectal cancer usi...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Elsayed E Hafez Source Type: research

Cognitive antihyperlipidemic and antioxidant activities of bitter leaf ( Vernonia amygdalina ) and Scent leaf ( Ocimum gratissimum )
Oxidative stress manifests an imbalance in the production and the detoxification of free radicals. Free radicals cause oxidative degradation of biomolecules like lipids, proteins, nucleic acids, and carbohydrate molecules, thereby compromising cell integrity and function and leading to health deterioration from a range of metabolic anomalies that cause diseases and ailments including cardiovascular diseases (CVD), hypertension, stroke and cancer. Both bitter leaf (VA) and Scent leaf (OG) have been medicinally useful in the cure of diseases in different cultures.The addition of scent leaf as additive in preparation of delic...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Ibukun Emmanuel Oluwafemi Source Type: research

Identification of natural products and their derivatives as promising inhibitors of protein glycation with non-toxic nature against mouse fibroblast 3T3 cells
This study was performed to identify new inhibitors of protein glycationin vitro. Protein glycation is one of the major causes of late diabetic complications. In this study, terpenoids and alkaloids, isolated from different medicinal plants, along with their derivatives, were evaluated for their antiglycation activityin vitro, while MTT assay on mouse fibroblast 3T3 cells was used to assess their potential cytotoxicity. Among the tested compounds, gossypol (2,2 ′-bis-(formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene) (1), isolated from Gossypium herbaceum,and its derivatives,gossypol acetic acid (2), gossypolidene...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Ghulam Abbas Source Type: research

 Evaluation of anticoagulant activity of aqueous extract of Cestrum nocturnum 
The study evaluated anticoagulant properties of the aqueous extract ofCestrum nocturnum using aPTT-Activated Partial Thromboplastin Time, PT- Prothrombin Time& TT-Thrombin Time as standard procedures.Forin vitro coagulation assays, aqueous extract of plant prolonged APTT, TT, and PT clotting times in a dose-dependent manner (Table 7). It prolonged APTT clotting time from 45 ± 2 (2mg/mL) to 82.2 ± 2.63s (10mg/mL), PT clotting time from 20.4 ± 1.49 (2mg/mL) to 31.4 ± 2.15s (10mg/mL), and TT clotting time from 9.2 ± 1.16 (2mg/mL) to 17.4 ± 1.01s (10mg/mL) at the concentration of 2 to 10mg/mL. Heparin prolonged APTT ...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Chandra Kishore Tyagi Source Type: research

Preclinical safety assessment and mutagenicity of the hydroethanolic extract of Syzygium campanulatum leaves.
In this study, we investigated the quality of dried leaves, chemical composition analyzed by FTIR and HPLC, phytochemicals content and repeated doses toxicity and mutagenicity effect of the hydroethanolic extract of S.campanulatum leaves (HESCL). The rats were divided into experimental and control groups and fed with 500, 1000, 2000 mg/kg/day of the hydroethanolic extract of S. campanulatum leaves for 28 and 90 days and with a single dose of 5000 mg/kg in acute study.The obtained results showed the dry leaves of S. campanulatum were devoid of any heavy metal and microbial contamination. The major components of HESCL were, ...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Elham Farsi Source Type: research

Ameliorative Effect of Chlorophyllin on Oxidative Stress in Experimental Model of Diabetes
The aim of this present study was to investigate the effect of chlorophyllin (CHL) on oxidative stress in Streptozotocine (STZ) induced diabetic mice. For the study, mice were divided into Group A: normal control, Group B: diabetic control, Group C: diabetic mice treated with the ascorbic acid, and Group D: diabetic mice treated with CHL. Levels of Reactive Oxygen Species (ROS), lipid peroxidation, protein carbonyl, superoxide dismutase (CuZn SOD&Mn-SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities were examined in kidney and heart tissues of different experimental groups. Hi...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Abani K Patar Source Type: research

Evaluation of essential oils from Boswellia sacra and Teucrium mascatense against acetyl cholinesterase enzyme and urease enzyme
In this study, the essential oil of frankincense exhibited significant inhibition with IC50 value of 0.043 ±0.02 mg/mL, against acetylcholinesterase enzyme while against urease enzyme it has shown good inhibition with IC50 value of 0.17 ± 0.05 mg/mL. The essential oil obtained from the Teucrium mascatense was found to be in active against both the enzymes. On acetylcholinesterase enzyme inhibition assay, the (+)- α- pinene exhibited significant inhibition (IC50 = 0.094 ±0.01 mg/mL) while (R)-+- limonenewas found to be inactive on this assay. Against urease enzyme (+)- α- pinene and (R)-+- limoneneshowed moderate activ...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Ghulam Abbas Source Type: research

 Isolation, evaluation and characterization of isolated compounds from aqueous extract of Cestrum nocturnum 
The aim of present study was to isolate, characeterise and evaluation anticoagulant properties of the isolated compound from aqueous extract of Cestrum nocturnum using aPTT-Activated Partial Thromboplastin Time, PT- Prothrombin Time& TT-Thrombin Time as standard procedures.From all the result it can be concluded that water extract of Cestrum nocturnumplant was found to be best among all the extract under study and from the isolates of water extract of Cestrum nocturnum plant AE5 was found to be best activity (anti-platelet, Fibrinolytic and anti-coagulant). Further fractionation of water extract generated two i...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Chandra Kishore Tyagi Source Type: research

Evaluation of anti-hyperglycemic and anti-hyperlipidemic effects of Naravelia zeylanica in streptozotocin- induced diabetic rats
Naravelia zeylanica DC (Ranunculaceae), a woody climber, have been used from ancient times to treat various ailments like rheumatoid arthritis, skin diseases, wound and ulcer. The present study was designed to investigate the anti-hyperglycemic activity of methanolic extract ofNaravelia zeylanica (NZYM) using experimental diabetic model. Diabetes was induced inwistar rats by a single dose of streptozotocin (55 mg/kg i.p.) (STZ) and treated with NZYM at doses of 100 and 200 mg/kg for 45 days. Glibenclamide (5 mg/kg b.w.) was used as standard drug. Blood glucose and body weight were monitored at regular intervals and the lev...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Rajakalanithi A Source Type: research

Anti-Helicobacter pylori effect of the antioxidant extract from Baccharis trimera Less. (DC)
One of the main risk factors for the development of stomach ulcers and cancer is infection withHelicobacter pylori bacteria, which is accompanied by considerable oxidative stress. Therefore, the aim of the present study was to assess the anti-Helicobacter pylori activity ofB. trimera hydroalcoholic extract (HE) and aqueous (AqF), hexanic (HxF), and acetonitrile/chloroform (ACF) fractions, as well as their oxidant potentials.A preliminary phytochemical screening was carried out. Anti-Helicobacter pylori activity was assessed using a microdilution assay. After exposure to the investigated samples, the bacterial morphology wa...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Rita de Cassia Ribeiro Goncalves Source Type: research

 Tephrosia purpurea : A natural herb/ bliss
Herbal medicine is in demand due to its fewer side effects and more or better curable techniques. TheTephrosia purpurea, claimed to be healing, curing and lower the various diseases according to Indian medicinal history. This genera species is well known for its therapeutic purpose, in this review we are explaining about the T.P most important characteristics which have been reported. This plant due to its good antioxidant and antibacterial property show best medicine against various diseases such as diuretic, cyto-toxicity and diabetics. (Source: International Journal of Phytomedicine)
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Richa Bhardwaj Source Type: research

A comprehensive review on Polygonum glabrum 
Polygonum glabrumcommonlycalled asdense flower knotweedis a perennial plant. It is an amphibious shrub withpink flowers and glossy brown seedsfound in most parts of India. Various parts of the plantlike leaves, stem, flowers and roots are used in traditional system of medicine. Traditionally, different decoctions/infusions are prepared using theplant parts and given for the treatment of rheumatism, jaundice, piles etc. From pharmacological point, the plant has been effectively screened for antihepatotoxic, antinephrotoxic, antimicrobial, anticancer, antidepressant, analgesic and antioxidant activities. The plant contains ...
Source: International Journal of Phytomedicine - February 17, 2017 Category: Science Authors: Raja S Source Type: research

Antifungal Activity of Weed Extracts on Candida Albicans : An In-vitro Study
The genusCandidais caused morbidity and mortality in human beings. The virulence factors of theCandida albicanshave the great role in the pseudohyphae formation by attached with epithelial cells and endothelial cells. The aim of the study was to evaluate the antifungal activity of weed extracts used intraditionalherbal medicine. The weeds were selected on the basis of their reported ethnobotanical uses. Water and alcoholic weed extracts were screenedin vitrofor their antifungal activity against fungusC. albicans. 50 μl concentration of minimal Inhibitory Concentration (MIC) ofMimosa pudica extract in alcohol and 70 μl co...
Source: International Journal of Phytomedicine - November 8, 2016 Category: Science Authors: Hemalatha Kamurthy Source Type: research