Evaluation of essential oils from < em > Boswellia sacra < /em > and < em > Teucrium mascatense < /em > against acetyl cholinesterase enzyme and urease enzyme

In this study, the essential oil of frankincense exhibited significant inhibition with IC50 value of 0.043 ±0.02 mg/mL, against acetylcholinesterase enzyme while against urease enzyme it has shown good inhibition with IC50 value of 0.17 ± 0.05 mg/mL. The essential oil obtained from the Teucrium mascatense was found to be in active against both the enzymes. On acetylcholinesterase enzyme inhibition assay, the (+)- α- pinene exhibited significant inhibition (IC50 = 0.094 ±0.01 mg/mL) while (R)-+- limonenewas found to be inactive on this assay. Against urease enzyme (+)- α- pinene and (R)-+- limoneneshowed moderate activity 40.06 ±1.03 % and 19.5±1.00 %, respectively. Interestingly, the mixture of equal concentration of (+)-α- pinene and (R)-+- limoneneexhibited 70% inhibition with IC50 value of (0.195 ± 0.10 mg/mL) which shows the synergistic relationship between them. Promising inhibitory potential of frankincense essential oil and (+)-α-pinene, against acetylcholinesterase enzyme and urease enzyme indicated their potential therapeutic role to manage Alzheimer’s disease and stomach ulcers, r espectively.
Source: International Journal of Phytomedicine - Category: Science Authors: Source Type: research