International Journal of Phytomedicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Qualitative Analysis and Antibacterial Activity of Pelargonium graveolenL’Herit
Medicinal plants are an important source of phytochemicals that offer traditional medicinal treatment of various ailments and one of the plants is Pelargonium Graveolens which was grown in Hyderabad province. The preliminary screening of their aerial leaves showed best results the presence of different phytochemical like alkaloids, flavonoids, glycosides, phenol, sterol and lignin found in Methanolic and Ethyl acetate extract. However chloroform extract revealed the absence of alkaloids and sterols, where as in Water extract flavonoids, phenol, sterol and lignin. The best resulted extracts from preliminary screening test w...
Source: International Journal of Phytomedicine - March 27, 2016 Category: Science Authors: Saraswathi Jaggali Source Type: research

Neuroprotective effects of sea buckthorn leaf extract against hypobaric hypoxia and post-hypoxic reoxygenation induced hippocampal damage in rats.
Exposure to hypobaric hypoxia (HBH) and reoxygenation (H/R) causes hippocampal neuronal damage leading to memory dysfunction and mood state alteration. The present study aimed at investigating the potential neuroprotective effect of seabuckthorn leaf extract ((SBTLE)) against HBH and reoxygenation induced neuronal injury in brain. Six groups of male sprague dawley rats were taken and exposed to simulated HBH equivalent at an altitude of 7600m in an animal decompression chamber for 7 days followed by reoxygenation. Rats were supplemented with SBTLE (100mg/kgBW) 20 days prior and during hypoxic exposure. Recovery from injuri...
Source: International Journal of Phytomedicine - March 27, 2016 Category: Science Authors: Iswar Baitharu Source Type: research

Antioxidant and antibacterial activity of extract and phases from stems of Spartium junceum L. growing in Algeria
This work aimed to evaluate the antioxidant and antibacterial activities of the hydroalcoholic (80% methanol) extract and n-hexane (n-Hex), chloroform (Chl), ethyl acetate (EtAc), and n-butanol (n-But) phases from Spartium junceum L. stems collected inAlgeria. Preliminary phytochemical investigations on phenolic compounds have been carried out.The total phenolic content, spectrophotometrically determined, ranged from 71.8095 ± 3.7136 mg GAE/g (extract) to 0.0582 ± 0.0106 mg GAE/g (n-Hex). By HPLC-PDA analysis flavonoids (flavone derivatives), p-hydroxybenzoic acid, p-hydroxycinnamic acid, and cinnamic acid derivatives we...
Source: International Journal of Phytomedicine - March 27, 2016 Category: Science Authors: Sofiane Habibatni Source Type: research

Synergistic effect of spices in a decoction regulates the energy metabolism in liver cancer cells
The objective of the study was to determine the synergistic effect of spices in a decoction; Turmeric (Curcuma longa), Pepper (Piper nigrum) and Garlic (Allium sativum) in combination, on the metabolism of Hep G2 liver cancer cells.The biochemical studies of 2 major enzymes involved in cellular metabolism of cells namely; Pyruvate dehydrogenase (PDH) and Lactate dehydrogenase A (LDHA) showed that the decoction down regulated the activity of LDHA and increased the activity of PDH in cancer cells, thereby shifting the metabolic mechanism towards normal functioning in the cancer cells. The expression studies of major molecule...
Source: International Journal of Phytomedicine - March 27, 2016 Category: Science Authors: Sheetal Ramachandran Source Type: research

Free radicals scavenging activity and antimicrobial potential of leaf and fruit extracts of Sapindus mukorossi Gaertn. against clinical pathogen
Antioxidant activity of fruit and leaf extracts of Sapindus mukorossi Gaertn. was evaluated through β- carotene/linoleic acid bleaching assay and hydrogen peroxide scavenging activity.  Antimicrobial potential of extracts was also assessed against human disease causing pathogens. In fruit extract, highest antioxidant activity (76.64 ± 1.06) was found in aqueous extract and leaf extract showed maximum antioxidant activity (90.82 ± 1.11) in methanolic extract. In fruit, maximum H2O2 scavenging activity was found in methanolic extract and in leaf maximum H2O2 scavenging activity (10.53 ± 0.72) in ethanolic extract. Both,...
Source: International Journal of Phytomedicine - March 27, 2016 Category: Science Authors: Reetika Singh Source Type: research

Chicory abrogates oxidative stress, inflammation and caspase-dependent apoptosis in acute hepatic injury model induced by acetaminophen in rats
In this study the protective effect of chicory leaves hydroalcoholic extract (CIE) against acute liver injury induced by a single dose of acetaminophen (700 mg/kg, i.p.) was investigated in rats. The CIE and silymarin treatment (standard reference) were given in a dose of (100 mg/kg, p.o.) for 3 days before and at 1 and 12 h following acetaminophen administration. Treatment with CIE significantly reduced the levels of serum ALT, AST, alkaline phosphatase, bilirubin, total cholesterol, triglycerides, urea, creatinine, TNF-α and hepatic contents of malondialdehyde (MDA), nitric oxide, caspase-3 and hydroxyproline, with sig...
Source: International Journal of Phytomedicine - March 27, 2016 Category: Science Authors: Mohamed Elsayed Nady Source Type: research

Identification of an antibacterial Withanolide (Dinoxin B) from leaf of Datura inoxia Mill.
Natural medicines are gaining popularity due to the alarming incidence of bacterial resistance even in regions with improved healthcare systems. Hence, there is a distinct and constant need for isolating medicinally active compounds from different natural sources. Taking this into consideration, experiment was done in order to isolate and identify an antibacterial compound from Datura inoxia through bioassay and Mass spectroscopy technique. The ethanol, hexane and aqueous leaf extracts of Datura inoxia were screened for (Source: International Journal of Phytomedicine)
Source: International Journal of Phytomedicine - March 27, 2016 Category: Science Authors: Chandni Tandon Source Type: research

In-vitro antioxidant activity of Cycas beddomei
The current study was to investigate antioxidant activity of methanol extract of whole plant of Cycas beddomei was administrated by utterly diverse models like DPPH radical scavenging assay, superoxide anion assay, nitric oxide radical inhibition assay, thiocyanate methodology, lipid peroxidation assay and hydroxyl radical scavenging assay. Methanol extract of Cycas beddomei showed effective antioxidant activity compared to straightforward antioxidants like ascorbic acid, rutin, curcumin, fat-soluble vitamin (Vitamin E) and α-tocopherol. The antioxidant activity depends upon the concentration and it had been increased wit...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Baggiya Selvi David Source Type: research

Phytochemical, antibacterial and antifungal activity of rhizome from Anaphyllum wightii.schott against clinical isolates and plant pathogens
Anaphyllumwightii.  Schott is a very rare and endemic threatened plant belonging to the family Areacea. It has been used in the tribal medicine to treat eczema, scabies and as antidote against snakebite.Different solvent extracts of Anaphyllumwightii.Schott were prepared and analysed for phytochemical screening by standard protocols. Antimicrobialactivity was measured using well diffusion method and micro dilution broth method against clinical isolates. The n-butanol and methanol extracts of A. wightii showedsignificant activity against all of the selected microorganisms. Water extract did not show any activity against an...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Manesh Kunjumon Source Type: research

Nutritional quality assessment and antiplasmodial activity of Cajanus cajan (L.) Huth., Crescentia cujete L. and Myrianthus preussii Engl. from Akure, Southwestern Nigeria
Conclusions and Application of Findings: Dietary or mineral elements serve structural, functional and biochemical roles. The three plants contained appreciable major and minor elements. The leaf of C. cajan could serve as a complement for animal protein. The activity observed in the ethanol extract could be as a result of the complete dissolution of the phytochemicals in ethanol. Toxicity studies on the plants will confirm their safe application, although lead tested negative in the plant samples. (Source: International Journal of Phytomedicine)
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Titus Adeniyi Olusi Source Type: research

Insulin sensitizing potential of fractions isolated from X. molluccensis and X. granatum
The present study was designed to elucidate the anti-hyperglycemic action of two fractions isolated from marine plants i.e., CDR267F018 from X. molluccensis and CDR134F194 from X. granatum in insulin resistant conditions using in vitro and in vivo models.The glucose uptake was studied using in vitro model of 3T3 L1 adipocyte and L-6 skeletal muscle cell line. The effect of fractions was also studied in dexamthazaone induced insulin resistant conditions in 3T3L1 adipocyte model. The in vivo model of insulin resistance was developed using a high fructose diet.  Parameters assessed were weight, fasting blood glucose, insulin...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Renuka Munshi Source Type: research

In vitro and in vivo evaluation for immunomodulatory activity of methanol extract of Sphaeranthus indicus (Linn)
The aim of the present investigation is to evaluate the immunomodulatory activity for methanolic extract of Sphaeranthus indicus Linn. at different doses as 100, 200 and 400 mg/kg bd.wt. in healthy wistar albino rats. The assessment of immunomodulatory activity was evaluated for humoral immunity (antibody titre, plaque forming cell assay and quantitative haemolysis of SRBC) and cellular immunity (delayed type hypersensitivity, T- cell population and drug induced myelosuppression) with antigen challenge by sheep RBCs. Methanolic extract of Sphaeranthus indicus along with the antigen (sheep red blood cells) showed significan...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Sneha J Anarthe Source Type: research

Anti-inflammatory and analgesic activities of Jateorhiza macrantha (Menispermaceae)
This study was performed to evaluate the analgesic and anti-inflammatory activities of its extract.The analgesic activity of the methanolic extract of Jateorhiza macrantha was investigated using the acetic acid (chemical) and tail-clip (mechanical) models of nociception in mice and the anti-inflammatory activity was investigated using the carrageenan-induced paw oedema in rats.  In acetic acid-induced writhing test, the extract at doses 100, 200 and 400 mg/kg significantly (P < 0.05, 0.01) reduced the writhing reflex in a dose dependent manner. In the application of the metal artery clip unto the tail of animals, the e...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Glory Oluremilekun Ajayi Source Type: research

Effect of ethanol extracts from Shorea robusta (Dipterocapaceae) bark in paracetamol induced liver damage in rats
The Hepato protective Activity of the ethanol extract of Shorea robusta was investigated against paracetamol induced hepatic damage. Paracetamol at the dose of 3gm/ kg produced liver damages in rats manifested by the significant (p<0.0005) rise in the level of SGOT, SGPT, ALP, (159.3 ± 3.637; 143.1 ± 1.215; 347.6 ±15.42) compare to with respective control values (51.85 ± 1.527; 26.65 ± 1.095; 84 ± 9.824) respectively. Pre-treatment of rats with the plant extracts 200mg /kg, 400mg/kg and standard (Silymarin 50 mg/ kg) lowered significantly (p<0005) respective serum (SGOT to 92.06±2.473 & 73.97 ±; SGPT to 6...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: DIPTANU BISWAS Source Type: research

Anti-inflammatory activity of phenolic extracts from different parts of prickly pear on lipopolysaccharide-stimulated N13 microglial cells
Phytochemicals with health-promoting activities that are components of human diet, have shown to exert a protective effect on the CNS under pathological conditions. In this sense, prickly pears exhibit analgesic and anti-inflammatory properties with neuroprotective effect.The purpose of this study was to evaluate the potential protective effect of phenolic extracts from different parts of prickly pear on the production of pro-inflammatory mediators by lipopolysaccharide (LPS) -stimulated N13 microglia. Activation of microglia, the hallmark of neuroinflammation, is key to host defence and tissue repair in brain. However, ac...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Makhlouf Chaalal Source Type: research