Anti-inflammatory and analgesic activities of Jateorhiza macrantha (Menispermaceae)

This study was performed to evaluate the analgesic and anti-inflammatory activities of its extract.The analgesic activity of the methanolic extract of Jateorhiza macrantha was investigated using the acetic acid (chemical) and tail-clip (mechanical) models of nociception in mice and the anti-inflammatory activity was investigated using the carrageenan-induced paw oedema in rats.  In acetic acid-induced writhing test, the extract at doses 100, 200 and 400 mg/kg significantly (P < 0.05, 0.01) reduced the writhing reflex in a dose dependent manner. In the application of the metal artery clip unto the tail of animals, the extract caused a significant (P < 0.05) dose dependent increase in reaction latency with peak effect (7.0%) inhibition produced at the highest dose of 400 mg/kg. In the carrageenan induced paw oedema test, the extract produced a dose dependent significant (P < 0.05, 0.01, 0.001) inhibition of oedema.The results obtained in this study lend credence to the ethnomedicinal use of the plant in the management of pain and inflammatory conditions.
Source: International Journal of Phytomedicine - Category: Science Authors: Source Type: research