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In vitro preliminary screening of bioactive compounds of different parts of Adansonia digitata L. a globally endangered tree
The present investigation was undertaken to screen the different parts of Adansonia digitata L. for the presence of bioactive compounds. The preliminary phytochemical screening was performed by using various solvent extracts of different parts such as leaf, seed, fruit wall and floral parts of A. digitata. The phytochemical analysis of the dry seeds, leaf, floral extracts, fruit wall and bark of stem was carried out to determine the presence of bioactive compounds using the standard qualitative procedures. The phytochemical analysis revealed that all the solvent extracts of different parts were rich in possession of flavon...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Samatha Talari Source Type: research

Studies on antimicrobial effect of natural dyes and pigments obtained from the leaf of Artocarpus heterophyllus Lam. and Tectona grandis L.f.
At present there is a renewed interest for value addition of textiles by using natural products. Many of the plant materials, from which natural dyes are obtained, also found to have some medicinal values. However, it is a matter of concern that the indigenous knowledge of extraction, processing and practice of using natural dyes has diminished to a great extent among the new generation of ethnic people due to easy availability of cheap synthetic dyes. In view of this, the present study was undertaken so as to revive and popularise the age-old art of dyeing with natural dyes.During the investigation dyeing materials were p...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Basanti Majhi Source Type: research

IN-VITRO NEPHROPROTECTIVE ROLE OF ETHANOLIC ROOT EXTRACT OF Boerhaavia diffusa AGAINST CISPLATIN-INDUCED NEPHROTOXICITY
This study showed that phytoconstituents present in B.diffusa could manage the nephrotoxicity induced by life saving drugs and it can be considered to be given as an adjuvant therapy.   (Source: International Journal of Phytomedicine)
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Kalaivani M.K Source Type: research

Plasmatic antioxidant capacity as a possible marker of phytodrugs efficacy
A correlation between drug plasma concentration and its therapeutic effect exist. Then we postulate that determination of plasmatic antioxidant capacity could prove phytodrugs efficacy. Therefore, we determined the plasmatic ability to reduce Fe3+ and malondialdehyde concentration after orally administration of herbal extracts to rats. For this, we use hydro-alcoholic extracts of Buddleja globosa Hope and Plantago major L. previously characterized according to their polyphenol and thiol compounds contents, and their capacities to inhibit the oxidation of microsomal lipid and thiol compounds.The amounts of polyphenol and th...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Andrea Muller Source Type: research

Physico-Chemical Characteristics and antioxidant Activity of Phenolic Compounds and oil of Citrus aurantium Seeds from Northwest Algeria
Sour orange (Citrus aurantium) is a tree of the family of Rutaceae. It is cultivated today in many parts of the world; the fruit, leaves, twigs and flowers have numerous applications in food and perfumery. Citrus aurantium used in this study originate from Tlemcen in North East of Algeria.Our study focused firstly on the physicochemical analysis of seed oil of sour orange namely the determination of indices, fatty acids, vitamin E and polyphenols.Secondly we evaluated total phenols, flavonoids, condensed tannins of Citrus aurantium seeds and their antioxidant activity of using in vitro methods: ferric reducing antioxidant ...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Brixi Nassima Gormat Source Type: research

Cytotoxicity Study in Non Malignant Fibroblast L929 Cell Line with Mucuna pruriens Seed Extract
Mucuna pruriens (L.) DC. (Leguminosae), commonly called velvet bean has been long used by tribes as an antidote for various snakebite, for treating depression and various nervous disorders, Parkinson's disease, arthritis and also has potent anti-urolithiatic, anti- diabetic, anti-cancer, anti-oxidant activities.To evaluate the potential cytotoxicity of the hydroalcoholic extract of Mucuna pruriens seeds in non-malignant fibroblast L929 cell line.To access the toxic nature of the seeds, a hydroalcoholic extract was prepared and tested for its cytotoxic effects on non-malignant fibroblast L929 cell line at various concentr...
Source: International Journal of Phytomedicine - January 25, 2016 Category: Science Authors: Acharya Bal Krishna Source Type: research

Acute Oral Toxicity Study of Paris polyphylla extract in Rats
Paris polyphylla Smith is regarded as “Wonder Herb” due to its vast therapeutic applications ranging from diarrhea to cancer. The cytotoxic effect of the rhizome extract on the healthy rats was monitored over a period of time. The extract proved non cytotoxic as animals gained weight and no signs of mortality, ill health or overt toxicity were observed. A brief period of dullness indicates a possible role of the extract in neuro-suppression. The cutoff median lethal dose (LD50) of extract after single oral administration to female rats, observed over a period of 14 days is found to be greater than 5000 mg/Kg body weigh...
Source: International Journal of Phytomedicine - November 2, 2015 Category: Science Authors: Acharya BalKrishna Source Type: research

Comparative evaluation of Baccharis trimera, Pimpinella anisum and statin on the biochemical profile of Wistar rats
Many are the plants for therapeutic purposes. Baccharis trimera is known to treat rheumatism, diabetes, and liver disorders. Pimpinella asinum is known to control colds, cough, bronchitis, fever, cramps and inflammation. The aim of this study was to evaluate the use of B. trimera and P. anisum and compare with statin effects on plasma lipids of Wistar rats. Sixty Animals were divided in control group (CG) and G2 (treated with anise), G3 (B. trimera) and G4 (simvastatin). Plants and statin were administrated by intra-gastric route twice a day for 30 days. No modifications in glycaemia were observed in the experimental group...
Source: International Journal of Phytomedicine - October 26, 2015 Category: Science Authors: Sandra Maria Barbalho Source Type: research

Relationship between antioxidant and anxiolytic activity of standardized extracts of Melissa officinalis and Rosmarinus officinalis
All diseases, especially those neurological pathologies (Depression, anxiety, Alzheimer and Parkinson’s diseases, etc) are described to be associated to oxidative stress. An increased concentration of metal ions in neurons of patients could be, at least in part, the cause of this oxidative stress. Reduced metal ions generate ROS through Haber-Weiss and/or Fenton reactions. By other hand, psychotropic effects of diverse plants have been described, between them Melissa officinalis and Rosmarinus officinalis. Pharmacological studies about the beneficial effects of these plants are scarce, especially those about Rosmarinus o...
Source: International Journal of Phytomedicine - October 26, 2015 Category: Science Authors: María Eugenia Letelier Source Type: research

Prevalence of HCV among Drug Addicts in Lahore and its Peripheries
HCV continues to be a major health threat globally; approximately 130 million people are infected around the world. The aim of the study was to describe the HCV prevalence in drug addicts the most deprived, isolated and most of the times poor part of our community. This was a cross sectional study focusing the drug addicts under treatment in rehabilitation centers. A total of 92 drug addicts were recruited from four different centers at Lahore including Silverlining Lahore, Silverlining Sheikhupura, Roshan Mustaqbil Lahore and Panah Lahore. All the subjects were tested for HCV RNA PCR, SGPT and SGOT. Out of 92 subjects 23 ...
Source: International Journal of Phytomedicine - October 26, 2015 Category: Science Authors: Abdul Basit Malik Source Type: research

Effect of a Proprietary Commiphora mukul Gum Resin Extract and Medium-Chain Triglyceride Preparation (GU-MCT810) on hypoxia-inducible factor-1 pathway in HepG2 cell line
The heterodimeric transcription factor HIF-1 is responsible for the regulation of genes that facilitate adaptation and survival of cells under hypoxic conditions. HIF-1 gene expression is also associated with angiogenesis, glucose transport, nitric oxide synthase activity and cell proliferation through the regulation of hundreds of genes associated with HIF-1 pathway. GU-MCT810 is a nutraceutical ingredient complex that includes a Commiphora mukul (guggul) extract prepared by a supercritical CO2-co-solvent extraction with ethanol and medium chain triglyceride (MCT) oil composed of C8 and C10 fatty acids. Since cancer cells...
Source: International Journal of Phytomedicine - October 26, 2015 Category: Science Authors: Cheppail Ramachandran Source Type: research

Evaluations of healing potential of ethanol extract from Macrothelypteris torresiana (Gaudich) aerial parts
The aim of the present study is to evaluate healing potential of 5% and 10% (w/w) ethanol extract from Macrothelypteris torresiana aerial parts (EEMTAP) in simple ointment (family thelypteridaceae). In excision wound model the ethanol extract from M. torresiana aerial parts showed significant increase in percentage wound closure and increased rate of epithelization. In incision wound model, EEMTAP treated animals showed increase in breaking strength when compared with control group. Similarly, the efficacy of treatment of chemical and thermal burn injuries in rats showed significant reduction in the burn wound area when co...
Source: International Journal of Phytomedicine - October 26, 2015 Category: Science Authors: Sumanta Mondal Source Type: research

Medicinal Plants on Acne inducing Bacteria
Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non-inflammatory (comedons, open and closed) lesions. Propionibacterium acnes and Staphylococcus epidermidis are common pus-forming microbes responsible for the development of various forms of Acne vulgaris. The present study was conducted to evaluate antimicrobial activities of seven medicinal plants against acne-inducing bacteria. Acetonic and aqueous extracts of Azadirachta indica (leaves), Curcuma longa (root), Aloe vera (leaves), Wi...
Source: International Journal of Phytomedicine - October 26, 2015 Category: Science Authors: Tanushree Tulsian Samanta Source Type: research

Endophytic Bacillus species isolated from mangrove plants, and their antagonestic effects against some pathogenic bacterial strains
This study aimed to isolate bacterial endophytes with potential antimicrobial effects from five mangrove plants and to investigate the stability of the most active metabolites under different PH and temperature.Bacterial colonies were isolated from the collected plant parts. Bacterial strains with potential antagonistic interactions were subjected to idnetification by VITEK 2 system or  sequencing of the 16S rRNA. MIC values of the crude substances were determined  against Bacillus cereus, Streptococcus uberis, Escherichia coli, Klebsiella pneumonia and Salmonella typhiumurium  using the the serial dilution technique.Th...
Source: International Journal of Phytomedicine - October 26, 2015 Category: Science Authors: Ibrahim MS Eldeen Source Type: research

Obtaining normal flexion and extension of knee joints on supine, prone and standing positions in osteoarthritis by topical phyto-therapeutic treatment irrespective of age and sex
Osteoarthritis (OA) is not a simply process of wear and tear, but an abnormal remodeling of joint tissues driven by a host of inflammatory mediators, including disorders of specific nerves within the affected joint. The common risk factor of OA includes age, sex, prior joint injury, obesity, genetic predisposition and mechanical factor, including malalignment and abnormal joint shape. This paper reports for the first time that normal flexion and extension of knee joints on supine, prone and standing positions in osteoarthritis by topical phytotherapeutic treatment can be achieved, with sustenance, irrespective of age and s...
Source: International Journal of Phytomedicine - October 26, 2015 Category: Science Authors: Apurba Ganguly Source Type: research