The feedback loop between miR-124 and TGF-{beta} pathway plays a significant role in non-small cell lung cancer metastasis
Increasing evidence shows that micro RNAs (miRNAs) play a critical role in tumor development. However, the role of miRNAs in non-small cell lung cancer (NSCLC) metastasis remains largely unknown. Here, we found that miR-124 expression was significantly impaired in NSCLC tissues and associated with its metastasis. In vitro and in vivo experiments indicate that restoring miR-124 expression in NSCLC cells had a marked effect on reducing cell migration, invasion and metastasis. Mechanistic analyses show that Smad4, a cobinding protein in transforming growth factor-β (TGF-β) pathway, was identified as a new target gen...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Zu, L., Xue, Y., Wang, J., Fu, Y., Wang, X., Xiao, G., Hao, M., Sun, X., Wang, Y., Fu, G., Wang, J. Tags: Original Manuscript Source Type: research
PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. By high-throughput transcriptome sequencing (RNA-Seq) profiling of three pairs of primary ESCCs and their corresponding non-tumorous tissues, we identified that prostate stem cell antigen (PSCA), a gene that encodes a glycosylphosphatidylinositol-anchored protein, is significantly downregulated in ESCC. Here, we reported decreased expression of PSCA in 188/218 (86.2%) of primary ESCC cases and was negatively regulated by its transcription factor sex-determining region Y-box5 that was s...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Zhang, L.-Y., Wu, J.-L., Qiu, H.-B., Dong, S.-S., Zhu, Y.-H., Lee, V. H.-F., Qin, Y.-R., Li, Y., Chen, J., Liu, H.-B., Bi, J., Ma, S., Guan, X.-Y., Fu, L. Tags: Original Manuscript Source Type: research
Ethanol and 4-methylpyrazole increase DNA adduct formation of furfuryl alcohol in FVB/N wild-type mice and in mice expressing human sulfotransferases 1A1/1A2
Furfuryl alcohol (FFA) is a carcinogenic food contaminant, which is formed by acid- and heat-catalyzed degradation of fructose and glucose. The activation by sulfotransferases (SULTs) yields a DNA reactive and mutagenic sulfate ester. The most prominent DNA adduct, N2-((furan-2-yl)methyl)-2'-deoxyguanosine (N2-MF-dG), was detected in FFA-treated mice and also in human tissue samples. The dominant pathway of FFA detoxification is the oxidation via alcohol dehydrogenases (ADHs) and aldehyde dehydrogenases (ALDHs). The activity of these enzymes may be greatly altered in the presence of inhibitors or competitive substrates. He...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Sachse, B., Meinl, W., Glatt, H., Monien, B. H. Tags: Original Manuscript Source Type: research
Low doses of gamma irradiation potentially modifies immunosuppressive tumor microenvironment by retuning tumor-associated macrophages: lesson from insulinoma
Tumor infiltrating iNOS+ macrophages under the influence of immunosuppressive tumor microenvironment gets polarized to tumor-promoting and immunosuppressive macrophages, known as tumor-associated macrophages (TAM). Their recruitment and increased density in the plethora of tumors has been associated with poor prognosis in cancer patients. Therefore, retuning of TAM to M1 phenotype would be a key for effective immunotherapy. Radiotherapy has been a potential non-invasive strategy to improve cancer immunotherapy and tumor immune rejection. Irradiation of late-stage tumor-bearing Rip1-Tag5 mice twice with 2 Gy dose resulted i...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Prakash, H., Klug, F., Nadella, V., Mazumdar, V., Schmitz-Winnenthal, H., Umansky, L. Tags: Original Manuscript Source Type: research
Na+/H+ exchanger 1, Na+/Ca2+ exchanger 1 and calmodulin complex regulates interleukin 6-mediated cellular behavior of human hepatocellular carcinoma
In conclusion, IL6 activates the functional activity of NHE1 and induces the functional and structural interaction of NHE1, NCX1 and CaM. The interaction of NHE1, NCX1 and CaM mediates the effects of IL6 on human HCC. (Source: Carcinogenesis)
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Xu, J., Ji, B., Wen, G., Yang, Y., Jin, H., Liu, X., Xie, R., Song, W., Song, P., Dong, H., Tuo, B. Tags: Original Manuscript Source Type: research
Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14 463 cases and 44 188 controls
Centrosome abnormalities are often observed in premalignant lesions and in situ tumors and have been associated with aneuploidy and tumor development. We investigated the associations of 9354 single-nucleotide polymorphisms (SNPs) in 106 centrosomal genes with lung cancer risk by first using the summary data from six published genome-wide association studies (GWASs) of the Transdisciplinary Research in Cancer of the Lung (TRICL) (12 160 cases and 16 838 controls) and then conducted in silico replication in two additional independent lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1319 cases...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Kang, X., Liu, H., Onaitis, M. W., Liu, Z., Owzar, K., Han, Y., Su, L., Wei, Y., Hung, R. J., Brhane, Y., McLaughlin, J., Brennan, P., Bickeböller, H., Rosenberger, A., Houlston, R. S., Caporaso, N., Landi, M. T., Heinrich, J., Risch, A., Wu, X., Tags: Original Manuscript Source Type: research
Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity
This study genotyped 10 known functional CYP2A6 genetic or copy number variants in 2115 current smokers from the multiethnic cohort study [African Americans (AA) = 350, Native Hawaiians (NH) = 288, Whites = 413, Latinos (LA) = 437 and Japanese Americans (JA) = 627] to conduct such an investigation. Here, we found that LA had the highest CYP2A6 activity followed by Whites, AA, NH and JA, who had the lowest levels. Adjusting for age, sex, race/ethnicity and body mass index, we found that CYP2A6 diplotypes were predictive of TNE levels, particularly in AA and JA (P trend < 0.0001). However, only in JA did the association r...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Park, S. L., Tiirikainen, M. I., Patel, Y. M., Wilkens, L. R., Stram, D. O., Le Marchand, L., Murphy, S. E. Tags: Original Manuscript Source Type: research
Intracellular location of BRCA2 protein expression and prostate cancer progression in the Swedish Watchful Waiting Cohort
Prostate cancer patients with inherited BRCA2 mutations have a survival disadvantage. However, it is unknown whether progression is associated with BRCA2 protein expression in diagnostic prostate cancer tissue, among men without inherited mutations. We conducted a nested case–control study within the Swedish Watchful Waiting cohort. The case group included all 71 patients who died from prostate cancer within 5 years from diagnosis and controls were all patients (n = 165) who lived at least 7 years after diagnosis. Tissue microarrays were stained using antibodies for C- and N-terminal domains of the BRCA2 protein. Loc...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Thorgeirsson, T., Jordahl, K. M., Flavin, R., Epstein, M. M., Fiorentino, M., Andersson, S.-O., Andren, O., Rider, J. R., Mosquera, J. M., Ingoldsby, H., Fall, K., Tryggvadottir, L., Mucci, L. A., on behalf of the Transdisciplinary Prostate Cancer Partner Tags: Original Manuscript Source Type: research
MicroRNA profiles in colorectal carcinomas, adenomas and normal colonic mucosa: variations in miRNA expression and disease progression
MiRNAs are small, non-protein-coding RNA molecules that regulate gene expression either by post-transcriptionally suppressing mRNA translation or by mRNA degradation. We examine differentially expressed miRNAs in colorectal carcinomas, adenomas and normal colonic mucosa. Data come from population-based studies of colorectal cancer conducted in Utah and the Kaiser Permanente Medical Care Program. A total of 1893 carcinoma/normal-paired samples and 290 adenoma tissue samples were run on the Agilent Human miRNA Microarray V19.0 which contained 2006 miRNAs. We tested for significant differences in miRNA expression between pair...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Slattery, M. L., Herrick, J. S., Pellatt, D. F., Stevens, J. R., Mullany, L. E., Wolff, E., Hoffman, M. D., Samowitz, W. S., Wolff, R. K. Tags: Original Manuscript Source Type: research
Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line HepG2 via JNK-mediated p62/SQSTM1 expression
Autophagy is a catabolic process that cancer cells usually exploit during stress conditions to provide energy by recycling organelles and proteins. Beyond its prosurvival role, it is well accepted that occurrence of autophagy is often associated with a particular type of programmed cell death known as autophagic cell death (ACD). Dehydroepiandrosterone (DHEA) is an endogenous hormone showing anticancer properties even if the underlying mechanisms are not fully clear yet. Here, we provide evidence that DHEA induces ACD in human hepatoma cell line, HepG2. Indeed, autophagy inhibitors (i.e. 3-methyladenine or Atg5 siRNA) sign...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Vegliante, R., Desideri, E., Di Leo, L., Ciriolo, M. R. Tags: Original Manuscript Source Type: research
Mucins and Wnt/{beta}-catenin signaling in gastrointestinal cancers: an unholy nexus
The Wnt/β-catenin signaling pathway is indispensable for embryonic development, maintenance of adult tissue homeostasis and repair of epithelial injury. Unsurprisingly, aberrations in this pathway occur frequently in many cancers and often result in increased nuclear β-catenin. While mutations in key pathway members, such as β-catenin and adenomatous polyposis coli, are early and frequent occurrences in most colorectal cancers (CRC), mutations in canonical pathway members are rare in pancreatic ductal adenocarcinoma (PDAC). Instead, in the majority of PDACs, indirect mechanisms such as promoter methylation, ...
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Authors: Pai, P., Rachagani, S., Dhawan, P., Batra, S. K. Tags: Review Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Carcinogenesis)
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
