Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction
Although a range of chemical exposures (cigarette smoking and occupational exposure) are recognized risk factors for the development of bladder cancer (BCa), many epidemiological studies have demonstrated that alcohol drinking is not associated with BCa risk. Aldehyde dehydrogenase 2 (ALDH2; rs671, Glu504Lys) and alcohol dehydrogenase 1B (ADH1B; rs1229984, His47Arg) polymorphisms impact the accumulation of acetaldehyde, resulting in an increased risk of various cancers. To date, however, no studies evaluating the association between BCa risk and alcohol drinking have considered these polymorphisms. Here, we conducted a mat...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Masaoka, H., Ito, H., Soga, N., Hosono, S., Oze, I., Watanabe, M., Tanaka, H., Yokomizo, A., Hayashi, N., Eto, M., Matsuo, K. Tags: Original Manuscript Source Type: research
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers
Aberrant telomere lengthening is an important feature of cancer cells in adults and children. In addition to somatic mutations, germline polymorphisms in telomere maintenance genes impact telomere length. Whether these telomere-associated polymorphisms affect risk of childhood malignancies remains largely unexplored. We collected genome-wide data from three groups with pediatric malignancies [neuroblastoma (N = 1516), acute lymphoblastic leukemia (ALL) (N = 958) and osteosarcoma (N = 660)] and three control populations (N = 6892). Using case–control comparisons, we analyzed eight single nucleotide polymorphisms (SNPs...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Walsh, K. M., Whitehead, T. P., de Smith, A. J., Smirnov, I. V., Park, M., Endicott, A. A., Francis, S. S., Codd, V., ENGAGE Consortium Telomere Group, Samani, N. J., Metayer, C., Wiemels, J. L. Tags: Original Manuscript Source Type: research
MiR-374a suppresses lung adenocarcinoma cell proliferation and invasion by targeting TGFA gene expression
Aberrant expression of miR-374a has been reported in several types of human cancers, including lung cancer. However, the functional significance and molecular mechanisms underlying the role of miR-374a in lung cancer remain largely unknown. We found that the expression of miR-374a was significantly downregulated in lung adenocarcinoma tissues compared to adjacent normal lung tissues in samples included in The Cancer Genome Atlas. Functional studies revealed that overexpression of miR-374a led to inhibition of lung adenocarcinoma cell proliferation, migration and invasion and that miR-374a negatively regulated transforming ...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Wu, H., Liu, Y., Shu, X. O., Cai, Q. Tags: Original Manuscript Source Type: research
CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma
In this study, we used chromatin immunoprecipitation together with high-throughput sequencing (ChIP-seq) and gene expression profiling by microarray analysis to assess genome-wide chromatin occupancy of H3K27ME3 in HCC cells. We identified that claudin14 (CLDN14) is a potentially direct target for EZH2-mediated H3K27ME3 in HCC. In a large cohort of clinical HCC tissues, we found that low expression of CLDN14 was significantly associated with advanced tumor stage and determined to be an independent predictor of shortened survival of HCC patients. Next, functional experiment demonstrated that depletion of CLDN14 substantiall...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Li, C.-P., Cai, M.-Y., Jiang, L.-J., Mai, S.-J., Chen, J.-W., Wang, F.-W., Liao, Y.-J., Chen, W.-H., Jin, X.-H., Pei, X.-Q., Guan, X.-Y., Zeng, M.-S., Xie, D. Tags: Original Manuscript Source Type: research
Genome-wide association study of colorectal cancer in Hispanics
We describe the first GWAS of common genetic variation contributing to CRC risk in HL (1611 CRC cases and 4330 controls). We also examine known susceptibility alleles and implement imputation-based fine-mapping to identify potential ethnicity-specific association signals in known risk regions. We discovered 17 variants across 4 independent regions that merit further investigation due to suggestive CRC associations (P < 1x10–6) at 1p34.3 (rs7528276; Odds Ratio (OR) = 1.86 [95% confidence interval (CI): 1.47–2.36); P = 2.5x10–7], 2q23.3 (rs1367374; OR = 1.37 (95% CI: 1.21–1.55); P = 4.0x10–7)...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Schmit, S. L., Schumacher, F. R., Edlund, C. K., Conti, D. V., Ihenacho, U., Wan, P., Van Den Berg, D., Casey, G., Fortini, B. K., Lenz, H.-J., Tusie-Luna, T., Aguilar-Salinas, C. A., Moreno-Macias, H., Huerta-Chagoya, A., Ordonez-Sanchez, M. L., Rodrigue Tags: Original Manuscript Source Type: research
Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2
The liver is a key metabolic organ that is essential for production of blood proteins, lipid and sugar metabolism and detoxification of naturally occurring and foreign harmful chemicals. To maintain its mass and many essential functions, the liver possesses remarkable regenerative capacity, but the latter also renders it highly susceptible to carcinogenesis. In fact, liver cancer often develops in the context of chronic liver injury. Currently, primary liver cancer is the second leading cause of cancer-related deaths, and as the rates of other cancers have been declining, the incidence of liver cancer continues to rise wit...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Karin, M., Dhar, D. Tags: Review Source Type: research
Understanding mutagenesis through delineation of mutational signatures in human cancer
Each individual cell within a human body acquires a certain number of somatic mutations during a course of its lifetime. These mutations originate from a wide spectra of both endogenous and exogenous mutational processes that leave distinct patterns of mutations, termed mutational signatures, embedded within the genomes of all cells. In recent years, the vast amount of data produced by sequencing of cancer genomes was coupled with novel mathematical models and computational tools to generate the first comprehensive map of mutational signatures in human cancer. Up to date, >30 distinct mutational signatures have been ide...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Petljak, M., Alexandrov, L. B. Tags: Review Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Carcinogenesis)
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Notice of Retraction
(Source: Carcinogenesis)
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Tags: Retraction Source Type: research
Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a devastating disease for which new treatments, such as immunotherapy are needed. Synthetic double-stranded RNAs, which activate toll-like receptor 3 (TLR3), have been used as potent adjuvants in cancer immunotherapy by triggering a proapoptotic response in cancer cells. A better understanding of the mechanism of TLR3-mediated apoptosis and its potential involvement in controlling tumor metastasis could lead to improvements in current treatment. Using paired, autologous primary and metastatic HNSCC cells we previously showed that metastatic, but not primary tumor-derived cel...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: McCormick, K. D., Ghosh, A., Trivedi, S., Wang, L., Coyne, C. B., Ferris, R. L., Sarkar, S. N. Tags: Original Manuscript Source Type: research
