Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer
In this study, we showed that ectopic expression of HMGA2 significantly enhanced cell migration and invasion in vitro and promoted tumor growth and distant metastasis in vivo. In contrast, the silencing of HMGA2 produced the opposite effects in vitro and in vivo. Chromatin immunoprecipitation-PCR and luciferase assays revealed that HMGA2 bound directly to the promoters of FN1 and IL11 and significantly induced their transcriptional activities. Moreover, as the direct downstream target of HMGA2, IL11 modulated cell migration and invasion through a pSTAT3-dependent signaling pathway. Furthermore, a strong positive correlatio...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: Wu, J., Wang, Y., Xu, X., Cao, H., Sahengbieke, S., Sheng, H., Huang, Q., Lai, M. Tags: Original Manuscript Source Type: research
Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells
In this study, we investigated the role of GRHL2 in oral carcinogenesis and the underlying mechanism. GRHL2 expression was elevated in cells and tissues of oral squamous cell carcinomas (OSCCs) compared with normal counterparts. Knockdown of GRHL2 resulted in the loss of in vivo tumorigenicity, cancer stemness and epithelial phenotype of oral cancer cells. GRHL2 loss also inhibited oral cancer cell proliferation and colony formation. GRHL2 regulated the expression of miR-200 family and Octamer-binding transcription factor 4 (Oct-4) genes through direct promoter DNA binding. Overexpression of miR-200 genes in the oral cance...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: Chen, W., Yi, J. K., Shimane, T., Mehrazarin, S., Lin, Y.-L., Shin, K.-H., Kim, R. H., Park, N.-H., Kang, M. K. Tags: Original Manuscript Source Type: research
Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model
There is emerging literature emphasizing the role of inflammatory eicosanoids, including prostaglandins and leukotrienes, in cancer development. Increased expression of both the cysteinyl leukotriene receptor 1 (CysLTR1) and the enzyme responsible for the production of leukotrienes, 5-lipoxygenase, is associated with poor prognosis in patients with colorectal adenocarcinomas. Apc mutation is an early event in the development of sporadic and hereditary (familial adenomatous polyposis) colorectal cancer. We utilized the ApcMin/+ mouse model of familial adenomatous polyposis/sporadic colorectal cancer to investigate the role ...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: Savari, S., Chandrashekar, N. K., Osman, J., Douglas, D., Bellamkonda, K., Jönsson, G., Juhas, M., Greicius, G., Pettersson, S., Sjölander, A. Tags: Original Manuscript Source Type: research
Pancreatic cancer: associations of inflammatory potential of diet, cigarette smoking and long-standing diabetes
Epidemiologic studies show strong associations between pancreatic cancer (PC) and inflammatory stimuli or conditions such as cigarette smoking and diabetes, suggesting that inflammation may play a key role in PC. Studies of dietary patterns and cancer outcomes also suggest that diet might influence an individual’s risk of PC by modulating inflammation. We therefore examined independent and joint associations between inflammatory potential of diet, cigarette smoking and long-standing (≥5 years) type II diabetes in relation to risk of PC. Analyses included data from 817 cases and 1756 controls. Inflammatory potentia...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: Antwi, S. O., Oberg, A. L., Shivappa, N., Bamlet, W. R., Chaffee, K. G., Steck, S. E., Hebert, J. R., Petersen, G. M. Tags: Original Manuscript Source Type: research
Genetic variation in one-carbon metabolism in relation to genome-wide DNA methylation in breast tissue from healthy women
Single-nucleotide polymorphisms (SNPs) in one-carbon metabolism genes and lifestyle factors (alcohol drinking and breast folate) may be determinants of whole-genome methylation in the breast. DNA methylation profiling was performed using the Illumina Infinium HumanMethylation450 BeadChip in 81 normal breast tissues from women undergoing reduction mammoplasty and no history of cancer. ANCOVA, adjusting for age, race and body mass index, was used to identify differentially methylated (DM) CpGs. Gene expression, by the Affymetrix GeneChip Human Transcriptome Array 2.0, was correlated with DM. Biological networks of DM genes w...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: Song, M.-A., Brasky, T. M., Marian, C., Weng, D. Y., Taslim, C., Llanos, A. A., Dumitrescu, R. G., Liu, Z., Mason, J. B., Spear, S. L., Kallakury, B. V. S., Freudenheim, J. L., Shields, P. G. Tags: Original Manuscript Source Type: research
Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis
In this study, plasma miRNAs of 40 MBC patients were profiled by TaqMan low density arrays and miRNAs with prognostic capacity were identified. The candidates were validated initially in the samples of 237 MBC patients and subsequently in 335 samples from an independent study cohort of BC patients. Sixteen miRNAs were established to be significantly associated with overall survival, and were termed as prognostic miRNA panel template (PROMPT). These included miR-141, miR-144, miR-193b, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-215, miR-365, miR-375, miR-429, miR-486-5p, miR-801, miR-1260 and miR-1274a. Additionall...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: Madhavan, D., Peng, C., Wallwiener, M., Zucknick, M., Nees, J., Schott, S., Rudolph, A., Riethdorf, S., Trumpp, A., Pantel, K., Sohn, C., Chang-Claude, J., Schneeweiss, A., Burwinkel, B. Tags: Original Manuscript Source Type: research
Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency
In this study, to investigate the in vivo oncogenic activities of one of the most frequently detected fusions, CD74-ROS1, as well as another SDC4-ROS1 fusion that has also been reported in several studies, we generated transgenic (TG) mouse strains that express either of the two ROS1-fusion genes specifically in lung alveolar type II cells. Mice in all TG lines developed tumorigenic nodules in the lung, and a few strains of both TG mouse lines demonstrated early-onset nodule development (multiple tumor lesions present in the lung at 2–4 weeks after birth); therefore, these two strains were selected for further invest...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: Inoue, M., Toki, H., Matsui, J., Togashi, Y., Dobashi, A., Fukumura, R., Gondo, Y., Minowa, O., Tanaka, N., Mori, S., Takeuchi, K., Noda, T. Tags: Original Manuscript Source Type: research
A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding
Genome-wide association studies (GWASs) have identified multiple susceptibility loci of colorectal cancer (CRC), however, causative polymorphisms have not been fully elucidated. Long non-coding RNAs (lncRNAs) are a recently discovered class of non-protein coding RNAs that involved in a wide variety of biological processes. We hypothesized that single nucleotide polymorphisms (SNPs) in lncRNA may associate with the CRC risk by influencing lncRNA functions. To evaluate the effects of SNPs on CRC susceptibility in Chinese populations, we first screened out all potentially functional SNPs in exons of lncRNAs located in CRC sus...
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Authors: Gong, J., Tian, J., Lou, J., Ke, J., Li, L., Li, J., Yang, Y., Gong, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J., Miao, X. Tags: Original Manuscript Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Carcinogenesis)
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - April 24, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Integrin-linked kinase as a novel molecular switch of the IL-6-NF-{kappa}B signaling loop in breast cancer
Substantial evidence has clearly demonstrated the role of the IL-6-NF-B signaling loop in promoting aggressive phenotypes in breast cancer. However, the exact mechanism by which this inflammatory loop is regulated remains to be defined. Here, we report that integrin-linked kinase (ILK) acts as a molecular switch for this feedback loop. Specifically, we show that IL-6 induces ILK expression via E2F1 upregulation, which, in turn, activates NF-B signaling to facilitate IL-6 production. shRNA-mediated knockdown or pharmacological inhibition of ILK disrupted this IL-6-NF-B signaling loop, and blocked IL-6-induced cancer stem ce...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Hsu, E.-C., Kulp, S. K., Huang, H.-L., Tu, H.-J., Chao, M.-W., Tseng, Y.-C., Yang, M.-C., Salunke, S. B., Sullivan, N. J., Chen, W.-C., Zhang, J., Teng, C.-M., Fu, W.-M., Sun, D., Wicha, M. S., Shapiro, C. L., Chen, C.-S. Tags: Original Manuscript Source Type: research
