Association of leukocyte telomere length in peripheral blood leukocytes with endometrial cancer risk in Caucasian Americans
Telomeres are the protective structure at the ends of each chromosome and play an important role in maintaining genomic integrity. Interindividual variation of telomere length in peripheral blood leukocytes has been associated with the risks of developing many human diseases including several cancers. The association between leukocyte telomere length (LTL) and endometrial cancer risk is still inconsistent. Using a case–control study of endometrial cancer patients (n = 139) and control subjects (n = 139) in a Caucasian population, we assessed the association of relative LTL with the risk of endometrial cancer. We calc...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Sun, Y., Zhang, L., Zhao, L., Wu, X., Gu, J. Tags: Original Manuscript Source Type: research
Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia
This study highlights the utility of using prior functional data for sequence variants in prioritization analyses to search for robust signals in the suggestive range. (Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Brenner, D. R., Amos, C. I., Brhane, Y., Timofeeva, M. N., Caporaso, N., Wang, Y., Christiani, D. C., Bickeböller, H., Yang, P., Albanes, D., Stevens, V. L., Gapstur, S., McKay, J., Boffetta, P., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J. Tags: Original Manuscript Source Type: research
Peripheral blood mitochondrial DNA copy number, length heteroplasmy and breast cancer risk: a replication study
Oxidative stress has consistently been linked to breast carcinogenesis, and mitochondria play a significant role in regulating reactive oxygen species generation. In our previous study, we found that increased levels of mitochondrial DNA (mtDNA) copy number and the presence of mitochondrial length heteroplasmies in the hypervariable (HV) regions 1 and 2 (HV1 and HV2) in peripheral blood are associated with increased risk of breast cancer. In current study with 1000 breast cancer cases and 1000 healthy controls, we intended to replicate our previous findings. Overall, levels of mtDNA copy number were significantly higher in...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Shen, J., Wan, J., Song, R., Zhao, H. Tags: Original Manuscript Source Type: research
Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects
Human cancers are often associated with numerical and structural chromosomal instability. Structural chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBL) arise as consequences of direct DNA damage or due to replication on a damaged DNA template. In both cases, DNA repair is critical and inter-individual differences in its capacity are probably due to corresponding genetic variations. We investigated functional variants in DNA repair genes (base and nucleotide excision repair, double-strand break repair) in relation to CAs, chromatid-type aberrations (CTAs) and chromosome-type aberrations (CSAs) in healthy in...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Vodicka, P., Musak, L., Frank, C., Kazimirova, A., Vymetalkova, V., Barancokova, M., Smolkova, B., Dzupinkova, Z., Jiraskova, K., Vodenkova, S., Kroupa, M., Osina, O., Naccarati, A., Palitti, F., Försti, A., Dusinska, M., Vodickova, L., Hemminki, Tags: Original Manuscript Source Type: research
Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study
In conclusion, smoking habits and green/yellow vegetable intake were associated with DNA methylation levels in gastric mucosae of healthy individuals with current H.pylori infection. Our study suggests that these risk factors may modify the effect of H.pylori on methylation induction and maintenance in gastric mucosa. (Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Shimazu, T., Asada, K., Charvat, H., Kusano, C., Otake, Y., Kakugawa, Y., Watanabe, H., Gotoda, T., Ushijima, T., Tsugane, S. Tags: Original Manuscript Source Type: research
Strong association between long and heterogeneous telomere length in blood lymphocytes and bladder cancer risk in Egyptian
Although it is widely recognized that telomere dysfunction plays an important role in cancer, the relationship between telomere function and bladder cancer risk is not well defined. In a case–control study of bladder cancer in Egypt, we examined relationships between two telomere features and bladder cancer risk. Telomere fluorescent in situ hybridization was used to measure telomere features using short-term cultured blood lymphocytes. Logistic regression was used to estimate the strength of association between telomere features and the risk of urothelial carcinoma of the bladder. High telomere length variation (TLV...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Wang, H., Wang, Y., Kota, K. K., Kallakury, B., Mikhail, N. N., Sayed, D., Mokhtar, A., Maximous, D., Yassin, E. H., Gouda, I., Sobitan, A., Sun, B., Loffredo, C. A., Zheng, Y.-L. Tags: Original Manuscript Source Type: research
The role of haplotype in 15q25.1 locus in lung cancer risk: results of scanning chromosome 15
The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case–control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case–control study with 2983 lung cancer patients and 3553 healthy controls of European ancestry for replication. Sliding window haplotype analysis within chromosome 15, evaluating 4722250 haplotypes and pair-wise haplotype analysis identified that CHRNA5 rs588765-rs16969968 was the most significant haplotype associat...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Ji, X., Gui, J., Han, Y., Brennan, P., Li, Y., McKay, J., Caporaso, N. E., Bertazzi, P. A., Landi, M. T., Amos, C. I. Tags: Original Manuscript Source Type: research
Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence
Cellular senescence is a largely irreversible form of cell cycle arrest triggered by various types of damage and stress, including oncogene expression (termed oncogene-induced senescence or OIS). We and others have previously demonstrated that OIS occurs in human benign lesions, acting as a potent tumor suppressor mechanism. Numerous phenotypic changes occur during OIS, both in the cytoplasm and in the nucleus. These include the activation of autophagy, a catabolic process operating in the cytoplasm and downregulation of lamin B1, a component of the nuclear lamina. However, it is unknown whether these changes relate to eac...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Lenain, C., Gusyatiner, O., Douma, S., van den Broek, B., Peeper, D. S. Tags: Original Manuscript Source Type: research
Novel perspectives of long non-coding RNAs in esophageal carcinoma
Esophageal carcinoma (EC) is one of the most aggressive cancer types worldwide. However, the underlying genomic events of EC are not fully understood. It is becoming evident that long non-coding RNAs (lncRNAs) play vital roles in tumorgenesis, metastasis, prognosis and diagnosis. Accumulating EC-related lncRNAs have been verified to involve in various biological processes through diverse functions including signal, decoy, scaffold and guide. However, the molecular mechanism of lncRNAs in EC has not been fully explored. In this review, we outline the functions and underlying mechanism of EC-related lncRNAs to pave the way f...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Lin, C.-Y., Xu, H.-M. Tags: Review Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
