Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - November 28, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - November 28, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Notice of Retraction
(Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Tags: Retraction Source Type: research
The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models
Although Epstein–Barr virus (EBV) infection is widely distributed, certain EBV-driven malignancies are geographically restricted. EBV-associated Burkitt’s lymphoma (eBL) is endemic in children living in sub-Saharan Africa. This population is heavily exposed to food contaminated with the mycotoxin aflatoxin B1 (AFB1). Here, we show that exposure to AFB1 in in vitro and in vivo models induces activation of the EBV lytic cycle and increases EBV load, two events that are associated with an increased risk of eBL in vivo. AFB1 treatment leads to the alteration of cellular gene expression, with consequent activations ...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Accardi, R., Gruffat, H., Sirand, C., Fusil, F., Gheit, T., Hernandez-Vargas, H., Le Calvez-Kelm, F., Traverse-Glehen, A., Cosset, F.-L., Manet, E., Wild, C. P., Tommasino, M. Tags: Original Manuscript Source Type: research
The NC11 domain of human collagen XVI induces vasculogenic mimicry in oral squamous cell carcinoma cells
Collagen XVI, a fibril-associated collagen with interrupted triple helix (FACIT) collagen, is involved in oral squamous cell carcinoma (OSCC) and glioblastoma progression. The NC11 domain of collagen XVI has been described previously with a strong implication in physiological processes. We detected the non-collagenous (NC) 11-domain in supernatants of OSCC cells after recombinant expression of full-length collagen XVI and in sera from OSCC patients and healthy individuals. Stable expression of NC11-green fluorescent protein (GFP) fusion protein in OSCC cells initiated proliferation control and block of anchorage-independen...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Bedal, K. B., Grässel, S., Spanier, G., Reichert, T. E., Bauer, R. J. Tags: Original Manuscript Source Type: research
Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis
In this study, we examined the mutagenic and tumorigenic activities of human pre-ovulatory FFs. A subset (6/11) of FFs was found with high levels of ROS whereas the antioxidant capacities were indifferent. These ROShigh FFs induced intracellular ROS and DSBs in the secretory cell population of fimbriae epithelium. When p53 and Rb were turned down, the FF-exposed secretory cells overcame apoptosis and expanded the population carrying ROS and DSB. The cancer initiation and promotion effects of FF were further recapitulated in Trp53 –/– mice. When introduced into the mammary fat pad, ROShigh but not ROSlow FF...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Huang, H.-S., Chu, S.-C., Hsu, C.-F., Chen, P.-C., Ding, D.-C., Chang, M.-Y., Chu, T.-Y. Tags: Original Manuscript Source Type: research
Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors
This study provides a possible etiological basis for oncocytic formation in heterogeneous Hürthle cell tumors through insufficient mitophagy leading to ineffective turnover of aberrant mitochondria caused by dysfunctional Parkin-mediated pathways of mitochondria quality control. (Source: Carcinogenesis)
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Lee, J., Ham, S., Lee, M. H., Kim, S. J., Park, J. H., Lee, S. E., Chang, J. Y., Joung, K. H., Kim, T. Y., Kim, J. M., Sul, H. J., Kweon, G. R., Jo, Y. S., Kim, K. S., Shong, Y. K., Gasparre, G., Chung, J. K., Porcelli, A. M., Shong, M. Tags: Original Manuscript Source Type: research
HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells
This study reveals a key role played by oxidative stress in promoting genomic instability and radiosensitivity in HPV-positive head and neck cancer. By employing an isogenic human cell model, we observed that expression of E6 and E7 is sufficient to induce reactive oxygen species (ROS) generation in head and neck cancer cells. E6/E7-induced oxidative stress is mediated by nicotinamide adenine dinucleotide phosphate oxidases (NOXs) and causes DNA damage and chromosomal aberrations. This mechanism for genomic instability distinguishes HPV-positive from HPV-negative tumors, as we observed NOX-induced oxidative stress in HPV-p...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Marullo, R., Werner, E., Zhang, H., Chen, G. Z., Shin, D. M., Doetsch, P. W. Tags: Original Manuscript Source Type: research
Akkermansia muciniphila and Helicobacter typhlonius modulate intestinal tumor development in mice
Gastrointestinal tumor growth is thought to be promoted by gastrointestinal bacteria and their inflammatory products. We observed that intestine-specific conditional Apc mutant mice (FabplCre;Apc 15lox/+) developed many more colorectal tumors under conventional than under pathogen-low housing conditions. Shotgun metagenomic sequencing plus quantitative PCR analysis of feces DNA revealed the presence of two bacterial species in conventional mice, absent from pathogen-low mice. One, Helicobacter typhlonius, has not been associated with cancer in man, nor in immune-competent mice. The other species, mucin-degrading Akkermans...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Dingemanse, C., Belzer, C., van Hijum, S. A. F. T., Günthel, M., Salvatori, D., Dunnen, J. T. d., Kuijper, E. J., Devilee, P., de Vos, W. M., van Ommen, G. B., Robanus-Maandag, E. C. Tags: Original Manuscript Source Type: research
Genomic copy number analysis of Chernobyl papillary thyroid carcinoma in the Ukrainian-American Cohort
One of the major consequences of the 1986 Chernobyl reactor accident was a dramatic increase in papillary thyroid carcinoma (PTC) incidence, predominantly in patients exposed to the radioiodine fallout at young age. The present study is the first on genomic copy number alterations (CNAs) of PTCs of the Ukrainian–American cohort (UkrAm) generated by array comparative genomic hybridization (aCGH). Unsupervised hierarchical clustering of CNA profiles revealed a significant enrichment of a subgroup of patients with female gender, long latency (>17 years) and negative lymph node status. Further, we identified single CN...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Selmansberger, M., Braselmann, H., Hess, J., Bogdanova, T., Abend, M., Tronko, M., Brenner, A., Zitzelsberger, H., Unger, K. Tags: Original Manuscript Source Type: research
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17
Solar ultraviolet irradiation is an environmental carcinogen that causes skin cancer. Caspase-7 is reportedly expressed at reduced levels in many cancers. The present study was designed to examine the role of caspase-7 in solar-simulated light (SSL)-induced skin cancer and to elucidate its underlying molecular mechanisms. Our study revealed that mice with genetic deficiency of caspase-7 are highly susceptible to SSL-induced skin carcinogenesis. Epidermal hyperplasia, tumor volume and the average number of tumors were significantly increased in caspase-7 knockout (KO) mice compared with SKH1 wild-type mice irradiated with S...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Lee, M.-H., Lim, D. Y., Kim, M. O., Lee, S.-Y., Shin, S. H., Kim, J. Y., Kim, S.-H., Kim, D. J., Jung, S. K., Yao, K., Kundu, J. K., Lee, H. S., Lee, C.-J., Dickinson, S. E., Alberts, D., Bowden, G. T., Stratton, S., Curiel, C., Einspahr, J., Bode, A. M., Tags: Original Manuscript Source Type: research
miR-544a induces epithelial-mesenchymal transition through the activation of WNT signaling pathway in gastric cancer
The epithelial–mesenchymal transition (EMT) contributes to cancer progression, as well as the development of normal organs, wound healing and organ fibrosis. We established a cell-based reporter system for identifying EMT-inducing microRNAs (miRNAs) with a gastric cancer (GC) cell line, MKN1, transfected with a reporter construct containing a promoter sequence of VIM in the 5' upstream region of the TurboRFP reporter gene. Function-based screening using this reporter system was performed with a 328-miRNA library, and resulted in the identification miR-544a as an EMT-inducing miRNA. Although miR-544a is already known ...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Yanaka, Y., Muramatsu, T., Uetake, H., Kozaki, K.-i., Inazawa, J. Tags: Original Manuscript Source Type: research
Transgenic mice overexpressing arginase 1 in monocytic cell lineage are affected by lympho-myeloproliferative disorders and disseminated intravascular coagulation
Arginase (ARG) is a metabolic enzyme present in two isoforms that hydrolyze l-arginine to urea and ornithine. In humans, ARG isoform 1 is also expressed in cells of the myeloid lineage. ARG activity promotes tumour growth and inhibits T lymphocyte activation. However, the two ARG transgenic mouse lines produced so far failed to show such effects. We have generated, in two different genetic backgrounds, transgenic mice constitutively expressing ARG1 under the control of the CD68 promoter in macrophages and monocytes. Both heterozygous and homozygous transgenic mice showed a relevant increase in mortality at early age, compa...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Astigiano, S., Morini, M., Damonte, P., Fraternali Orcioni, G., Cassanello, M., Puglisi, A., Noonan, D. M., Bronte, V., Barbieri, O. Tags: Original Manuscript Source Type: research
Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer
Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic variants [single nucleotide polymorphisms (SNPs) and indels] in DNA repair genes and EOC risk. We genotyped 2896 common variants at 143 gene loci in DNA samples from 15 397 patients with invasive EOC and controls. We found evidence of associations with EOC risk for variants at FANCA, EXO1, E2F4, E2F2, CREB5 and CHEK2 genes (P ≤ 0.001). The strongest risk association was for CHEK2 SNP rs17507066 with ...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Lawrenson, K., Iversen, E. S., Tyrer, J., Weber, R. P., Concannon, P., Hazelett, D. J., Li, Q., Marks, J. R., Berchuck, A., Lee, J. M., Aben, K. K. H., Anton-Culver, H., Antonenkova, N., Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer Tags: Original Manuscript Source Type: research
Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters
Enhancer of zeste homolog 2 (EZH2) plays an important role in tumor development and progression by interacting with histone and nonhistone proteins. In the current study, we analyzed prevalence and prognostic impact of EZH2 in prostate cancer. EZH2 expression was analyzed by immunohistochemistry on a tissue microarray containing more than 12400 prostate cancer specimens. Results were compared to tumor phenotype, biochemical recurrence and molecular subtypes defined by ERG status as well as genomic deletions of 3p, 5q, 6q and PTEN. EZH2 immunostaining was detectable in 56.6% of 10168 interpretable cancers and considered str...
Source: Carcinogenesis - October 29, 2015 Category: Cancer & Oncology Authors: Melling, N., Thomsen, E., Tsourlakis, M. C., Kluth, M., Hube-Magg, C., Minner, S., Koop, C., Graefen, M., Heinzer, H., Wittmer, C., Sauter, G., Wilczak, W., Huland, H., Simon, R., Schlomm, T., Steurer, S., Krech, T. Tags: Original Manuscript Source Type: research
