Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model
The rising incidence of human papillomavirus (HPV)-associated malignancies, especially for oropharyngeal cancers, has highlighted the urgent need to understand how the interplay between high-risk HPV oncogenes and carcinogenic exposure results in squamous cell carcinoma (SCC) development. Here, we describe an inducible mouse model expressing high risk HPV-16 E6/E7 oncoproteins in adults, bypassing the impact of these viral genes during development. HPV-16 E6/E7 genes were targeted to the basal squamous epithelia in transgenic mice using a doxycycline inducible cytokeratin 5 promoter (cK5-rtTA) system. After doxycycline ind...
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Callejas-Valera, J. L., Iglesias-Bartolome, R., Amornphimoltham, P., Palacios-Garcia, J., Martin, D., Califano, J. A., Molinolo, A. A., Gutkind, J. S. Tags: Original Manuscript Source Type: research
Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells
This study shows that PZ-DHA is selectively cytotoxic to breast cancer cells in vitro and in vivo, suggesting that further investigations of PZ-DHA are warranted as a potential treatment for breast cancer. (Source: Carcinogenesis)
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Fernando, W., Coombs, M. R. P., Hoskin, D. W., Rupasinghe, H. P. V. Tags: Original Manuscript Source Type: research
Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny
In this study, we analyzed the effects of selective Aurora B inhibition using AZD1152-HQPA/Barasertib (AZD1152) on HCT116 cells, U87-MG, corresponding isogenic p53-deficient cells and a primary glioblastoma cell line. AZD1152 treatment caused polyploidy and non-apoptotic cell death in all cell lines irrespective of p53 status and was accompanied by poly-merotelic kinetochore–microtubule attachments and DNA damage. In p53 wild-type cells a DNA damage response induced an inefficient pseudo-G1 cell cycle arrest, which was not able to halt ongoing endoreplication of cells. Of note, release of tumor cells from AZD1152 res...
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Wiedemuth, R., Klink, B., Fujiwara, M., Schröck, E., Tatsuka, M., Schackert, G., Temme, A. Tags: Original Manuscript Source Type: research
Gender differences in cancer susceptibility: role of oxidative stress
Cancer is a leading cause of death worldwide and environmental factors, including chemicals, have been suggested as major etiological incitements. Cancer statistics indicates that men get more cancer than women. However, differences in the known risk factors including life style or occupational exposure only offer partial explanation. Using a text mining tool, we have investigated the scientific literature concerning male- and female-specific rat carcinogens that induced tumors only in one gender in NTP 2-year cancer bioassay. Our evaluation shows that oxidative stress, although frequently reported for both male- and femal...
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Ali, I., Högberg, J., Hsieh, J.-H., Auerbach, S., Korhonen, A., Stenius, U., Silins, I. Tags: Original Manuscript Source Type: research
p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth
Cancer-associated fibroblasts (CAFs) create a microenvironment that contributes to tumor growth; however, the mechanism by which fibroblasts are phenotypically altered to CAFs remains unclear. Loss or mutation of the tumor suppressor p53 plays a crucial role in cancer progression. Herein, we analyzed how the p53 status of cancer cells affects fibroblasts by investigating the in vivo and in vitro effects of loss of p53 function in cancer cells on phenotypic changes in fibroblasts and subsequent tumor progression in human colon cancer cell lines containing wild-type p53 and in cells with a p53 functional deficiency. The grow...
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Hayashi, Y., Tsujii, M., Kodama, T., Akasaka, T., Kondo, J., Hikita, H., Inoue, T., Tsujii, Y., Maekawa, A., Yoshii, S., Shinzaki, S., Watabe, K., Tomita, Y., Inoue, M., Tatsumi, T., Iijima, H., Takehara, T. Tags: Original Manuscript Source Type: research
Genetic variants of the Wnt signaling pathway as predictors of aggressive disease and reclassification in men with early stage prostate cancer on active surveillance
In this study, we used a three-phase design. In phases I and II prostate cancer patient cohort, 578 single nucleotide polymorphisms (SNPs) from 45 genes of the Wnt signaling pathway were analyzed in 1762 localized prostate cancer patients. Twelve SNPs from four regions were significantly associated with aggressive disease, among which, three linked SNPs in CSNK1A1 at 5q32 (represented by rs752822) may differentiate GS 4+3 from GS 3+4 patients (OR = 1.44, 95% CI = 1.12–1.87, P = 4.76x10-3). In phase III active surveillance (AS) cohort, genotyping of rs752822 (candidate from phases I and II) and previously identified r...
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Shu, X., Ye, Y., Gu, J., He, Y., Davis, J. W., Thompson, T. C., Logothetis, C. J., Kim, J., Wu, X. Tags: Original Manuscript Source Type: research
Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients
Germline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (P < 10–5) the association between 30 genomic regions and PDAC OS. With the aim to highlight the true associations within these regions, we analyzed 44 single-nucleotide polymorphisms (SNPs) in the 30 candidate regions in 1722 PDAC patients within the PANcreatic Disease ReseArch (PANDoRA) consortium. We observed statistically significant associations for five of the selected regio...
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Rizzato, C., Campa, D., Talar-Wojnarowska, R., Halloran, C., Kupcinskas, J., Butturini, G., Mohelnikova-Duchonova, B., Sperti, C., Tjaden, C., Ghaneh, P., Hackert, T., Funel, N., Giese, N., Tavano, F., Pezzilli, R., Pedata, M., Pasquali, C., Gazouli, M., Tags: Original Manuscript Source Type: research
Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium
In conclusion, common genetic variations in the Hippo signaling pathway may contribute to both ER-negative and ER+ breast cancer risk in AA women. (Source: Carcinogenesis)
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Zhang, J., Yao, S., Hu, Q., Zhu, Q., Liu, S., Lunetta, K. L., Haddad, S. A., Yang, N., Shen, H., Hong, C.-C., Sucheston-Campbell, L., Ruiz-Narvaez, E. A., Bensen, J. T., Troester, M. A., Bandera, E. V., Rosenberg, L., Haiman, C. A., Olshan, A. F., Palmer, Tags: Original Manuscript Source Type: research
Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer
Early detection of colorectal cancer is the main prerequisite for successful treatment and reduction of mortality. Circulating microRNAs were previously identified as promising diagnostic, prognostic and predictive biomarkers. The purpose of this study was to identify serum microRNAs enabling early diagnosis and prognosis prediction of colon cancer. In total, serum samples from 427 colon cancer patients and 276 healthy donors were included in three-phase biomarker study. Large-scale microRNA expression profiling was performed using Illumina small RNA sequencing. Diagnostic and prognostic potential of identified microRNAs w...
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Vychytilova-Faltejskova, P., Radova, L., Sachlova, M., Kosarova, Z., Slaba, K., Fabian, P., Grolich, T., Prochazka, V., Kala, Z., Svoboda, M., Kiss, I., Vyzula, R., Slaby, O. Tags: Original Manuscript Source Type: research
Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan
Endosulfan (ES) is an organochlorine pesticide, speculated to be associated with chromosomal abnormalities and diseases in humans. However, very little is known about the mechanism of its genotoxicity. Using in vivo, ex vivo and in vitro model systems, we show that exposure to ES induces reactive oxygen species (ROS) in a concentration and time-dependent manner. The generation of ROS results in DNA double-strand breaks either directly or in a replication-dependent manner, both in mice and human cells. Importantly, ES-induced DNA damage evokes DNA damage response, resulting in elevated levels of classical non-homologous DNA...
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Authors: Sebastian, R., Raghavan, S. C. Tags: Original Manuscript Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
