Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Significant interactions between maternal PAH exposure and single nucleotide polymorphisms in candidate genes on B[a]P-DNA adducts in a cohort of non-smoking Polish mothers and newborns
Polycyclic aromatic hydrocarbons (PAH) are a class of chemicals common in the environment. Certain PAH are carcinogenic, although the degree to which genetic variation influences susceptibility to carcinogenic PAH remains unclear. Also unknown is the influence of genetic variation on the procarcinogenic effect of in utero exposures to PAH. Benzo[a]pyrene (B[a]P) is a well-studied PAH that is classified as a known human carcinogen. Within our Polish cohort, we explored interactions between maternal exposure to airborne PAH during pregnancy and maternal and newborn single nucleotide polymorphisms (SNPs) in plausible B[a]P me...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Iyer, S., Wang, Y., Xiong, W., Tang, D., Jedrychowski, W., Chanock, S., Wang, S., Stigter, L., Mroz, E., Perera, F. Tags: Original Manuscript Source Type: research
Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation
Mesotheliomas are frequently characterized by disruption of Hippo pathway due to deletion and/or mutation in genes, such as neurofibromin 2 (NF2). Hippo disruption attenuates yes-associated protein (YAP) phosphorylation allowing YAP to translocate to the nucleus and regulate gene expression. The role of disrupted Hippo pathway in maintenance of established mesotheliomas has been extensively investigated using cell lines; however, its involvement in development of human mesothelioma has not been explored much. Here, we employed immortalized human mesothelial cells to disrupt Hippo pathway. YAP phosphorylation was reduced on...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Kakiuchi, T., Takahara, T., Kasugai, Y., Arita, K., Yoshida, N., Karube, K., Suguro, M., Matsuo, K., Nakanishi, H., Kiyono, T., Nakamura, S., Osada, H., Sekido, Y., Seto, M., Tsuzuki, S. Tags: Original Manuscript Source Type: research
Silencing of ST6Gal I enhances colorectal cancer metastasis by down-regulating KAI1 via exosome-mediated exportation and thereby rescues integrin signaling
Aberrant sialylation has long been correlated with human cancer. Increased ST6 Gal I (β-galactoside α 2, 6 sialyltransferase) and consequently higher levels of cell-surface α 2, 6 sialylation has been associated with human colorectal cancer (CRC) metastasis. We have extensive circumstantial data that sialylation is connected to cancer metastasis, but we do not understand in detail how sialylation can switch on/off multiple steps in cancer metastasis. To investigate the molecular mechanism underlying the ST6Gal I-mediated metastasis of CRC, we silenced the ST6Gal I gene in a metastatic SW620 CRC cell line (...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Jung, Y. R., Park, J.-J., Jin, Y. B., Cao, Y. J., Park, M.-J., Kim, E. J., Lee, M. Tags: Original Manuscript Source Type: research
Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer
Recently, we have reported that apoptosis-inducing factor (AIF) regulates the epithelial–mesenchymal transition (EMT) process of cancers, but the mechanisms underlying the regulation of AIF expression in cancers remain greatly unknown. Here, we report that hypoxia inversely correlates with the expression of AIF in tumor tissues from a cohort of colon cancer patients and inhibits AIF expression in multiple colon cancer cell lines. This inhibition is mediated by hypoxia-inducible factor-1 (HIF-1), which transcriptionally represses AIF through direct binding to the hypoxia-response element in AIF promoter as revealed by...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Xiong, Z., Guo, M., Yu, Y., Zhang, F.-F., Ge, M.-K., Chen, G.-Q., Shen, S.-M. Tags: Original Manuscript Source Type: research
Effect of human papillomavirus seropositivity and E2F2 promoter variants on risk of squamous cell carcinomas of oropharynx and oral cavity
Given roles of HPV and genetic factors in cancer risk, we evaluated associations of HPV16 seropositivity and five E2F2 promoter variants with squamous cell carcinoma of oropharynx (SCCOP) and squamous cell carcinoma of oral cavity (SCCOC) risk in a case–control study of 325 patients and 335 cancer-free matched controls. We found that HPV16 seropositivity was significantly associated with SCCOP risk (aOR, 5.4, 95%CI, 3.7–8.9) but not SCCOC (aOR, 0.8, 95%CI, 0.4–1.5), while each E2F2 polymorphism had no significant main effect on SCCOP and SCCOC risk. However, after combining HPV serological status and E2F2...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Li, Y., Sturgis, E. M., Yuan, Y., Lu, M., Cao, X., Wei, Q., Li, G. Tags: Original Manuscript Source Type: research
Association of serum cotinine levels and lung cancer mortality in non-smokers
This study was performed to quantify the association between mortality and known and unknown secondhand smoke (SHS) exposure as measured by cotinine levels in non-smokers. Data collected from 1999 to 2010 in the National Health and Nutrition Examination Survey (NHANES) were linked to the National Death Index. Self-reported non-smokers aged ≥20 years (N = 20 175) were studied. Serum cotinine was measured at recruitment; non-smokers were those with cotinine below the reported race-specific cut-off points (5.92, 4.85 and 0.84ng/ml for non-Hispanic blacks, non-Hispanic whites and Mexican Americans, and 3.08ng/ml for all oth...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Flores, R. M., Liu, B., Taioli, E. Tags: Original Manuscript Source Type: research
Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk
The poor clinical outcome of pancreatic cancer (PC) is largely attributed to its aggressive nature and refractoriness to currently available therapeutic modalities. We previously reported antitumor efficacy of honokiol (HNK), a phytochemical isolated from various parts of Magnolia plant, against PC cells in short-term in vitro growth assays. Here, we report that HNK reduces plating efficiency and anchorage-independent growth of PC cells and suppresses their migration and invasiveness. Furthermore, significant inhibition of pancreatic tumor growth by HNK is observed in orthotopic mouse model along with complete-blockage of ...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Averett, C., Bhardwaj, A., Arora, S., Srivastava, S. K., Khan, M. A., Ahmad, A., Singh, S., Carter, J. E., Khushman, M., Singh, A. P. Tags: Original Manuscript Source Type: research
TGF-{beta}-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer in part due to inherent resistance to chemotherapy, including the first-line drug gemcitabine. Although low expression of the nucleoside transporters hENT1 and hCNT3 that mediate cellular uptake of gemcitabine has been linked to gemcitabine resistance, the mechanisms regulating their expression in the PDAC tumor microenvironment are largely unknown. Here, we report that the matricellular protein cysteine-rich angiogenic inducer 61 (CYR61) negatively regulates the nucleoside transporters hENT1 and hCNT3. CRISPR/Cas9-mediated knockout of CYR61 increased expression of...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Hesler, R. A., Huang, J. J., Starr, M. D., Treboschi, V. M., Bernanke, A. G., Nixon, A. B., McCall, S. J., White, R. R., Blobe, G. C. Tags: Original Manuscript Source Type: research
Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer
Mouse double minute 2 (MDM2) protein functionally inactivates the tumor suppressor p53 in human cancer. Conventional MDM2 inhibitors provide limited clinical application as they interfere only with the MDM2–p53 interaction to release p53 from MDM2 sequestration but do not prevent activated p53 from transcriptionally inducing MDM2 expression. Here, we report a rationally synthesized chalcone-based pyrido[b]indole, CPI-7c, as a unique small-molecule inhibitor of MDM2, which not only inhibited MDM2–p53 interaction but also promoted MDM2 degradation. CPI-7c bound to both RING and N-terminal domains of MDM2 to promo...
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Authors: Singh, A. K., Chauhan, S. S., Singh, S. K., Verma, V. V., Singh, A., Arya, R. K., Maheshwari, S., Akhtar, M. S., Sarkar, J., Rangnekar, V. M., Chauhan, P. M. S., Datta, D. Tags: Original Manuscript Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - October 25, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
