Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo
In conclusion, these data suggest that molecules such as carnosic acid could be further evaluated and optimized as a potential therapeutic alternative to target AR in prostate cancer. (Source: Carcinogenesis)
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Petiwala, S. M., Li, G., Bosland, M. C., Lantvit, D. D., Petukhov, P. A., Johnson, J. J. Tags: Original Manuscript Source Type: research
Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes
Cholangiocarcinoma is a relatively rare cancer, but its incidence is increasing worldwide. Although several risk factors have been suggested, the etiology and pathogenesis of the majority of cholangiocarcinomas remain unclear. Recently, a high incidence of early-onset cholangiocarcinoma was reported among the workers of a printing company in Osaka, Japan. These workers underwent high exposure to organic solvents, mainly haloalkanes such as 1,2-dichloropropane (1,2-DCP) and/or dichloromethane. We performed whole-exome analysis on four cases of cholangiocarcinoma among the printing workers. An average of 44.8 somatic mutatio...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Mimaki, S., Totsuka, Y., Suzuki, Y., Nakai, C., Goto, M., Kojima, M., Arakawa, H., Takemura, S., Tanaka, S., Marubashi, S., Kinoshita, M., Matsuda, T., Shibata, T., Nakagama, H., Ochiai, A., Kubo, S., Nakamori, S., Esumi, H., Tsuchihara, K. Tags: Original Manuscript Source Type: research
Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias
Carcinogen exposures inscribe mutation patterns on cancer genomes and sometimes bias the acquisition of driver mutations toward preferred oncogenes, potentially dictating sensitivity to targeted agents. Whether and how carcinogen-specific mutation patterns direct activation of preferred oncogenes remains poorly understood. Here, mouse models of breast cancer were exploited to uncover a mechanistic link between strand-biased mutagenesis and oncogene preference. When chemical carcinogens were employed during Wnt1-initiated mammary tumorigenesis, exposure to either 7,12-dimethylbenz(a)anthracene (DMBA) or N-ethyl-N-nitrosoure...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Keller, R. R., Gestl, S. A., Lu, A. Q., Hoke, A., Feith, D. J., Gunther, E. J. Tags: Original Manuscript Source Type: research
Role of Cdc6 in re-replication in cells expressing human papillomavirus E7 oncogene
The E7 oncoprotein of high-risk human papillomavirus (HPV) types induces DNA re-replication that contributes to carcinogenesis; however, the mechanism is not fully understood. To better understand the mechanism by which E7 induces re-replication, we investigated the expression and function of cell division cycle 6 (Cdc6) in E7-expressing cells. Cdc6 is a DNA replication initiation factor and exhibits oncogenic activities when overexpressed. We found that in E7-expressing cells, the steady-state level of Cdc6 protein was upregulated and its half-life was increased. Cdc6 was localized to the nucleus and associated with chrom...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Fan, X., Zhou, Y., Chen, J. J. Tags: Original Manuscript Source Type: research
{beta}III-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells
This study aimed to investigate the role of βIII-tubulin in glucose stress response signaling and the survival and proliferation of NSCLC cells. This study revealed that βIII-tubulin regulates cellular metabolism and glucose stress response signaling in NSCLC cells to promote cell survival and proliferation in glucose starvation. βIII-Tubulin decreases the reliance of cells on glycolytic metabolism, priming them to cope with variable nutrient supply present within the tumor microenvironment. βIII-Tubulin protects cells from endoplasmic reticulum (ER) stress and reduces both basal and glucose starvation&...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Parker, A. L., Turner, N., McCarroll, J. A., Kavallaris, M. Tags: Original Manuscript Source Type: research
Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway
Keratins (K) are intermediate filament proteins important in protection from cellular stress. K8, K18 and K19 are the main components of keratin filaments in colonic epithelia but their role in intestinal diseases remains ambiguous. A function for keratins in intestinal health is supported by the K8-knock-out (K8–/–) mouse which manifests an early chronic ulcerative colitis-like inflammatory bowel disease and epithelial hyperproliferation. We tested whether K8–/– mice are more susceptible to colorectal cancer (CRC) compared to K8 wild type (K8+/+), and K8 heterozygote (K8+/–) mice showing incr...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Misiorek, J. O., Lähdeniemi, I. A. K., Nyström, J. H., Paramonov, V. M., Gullmets, J. A., Saarento, H., Rivero-Müller, A., Husoy, T., Taimen, P., Toivola, D. M. Tags: Original Manuscript Source Type: research
Prognostic significance of inflammatory factors expression by stroma from breast carcinomas
The aim of this work was to evaluate the expression and clinical relevance of some cytokines in breast carcinomas. An immunohistochemical study using tissue arrays and specific antibodies against interleukin 1β (IL-1β), IL-6, IL-10, IL-17, interferon β (IFNβ) and nuclear factor kappa B (NFB) was performed in 108 breast carcinomas. Most studied cytokines were mainly expressed by cancer cells but also by stromal cells as cancer-associated fibroblasts (CAFs) or mononuclear inflammatory cells (MICs). Global expression (score) of IL-1β and IL-17 was positively associated with histological grade; human e...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Fernandez-Garcia, B., Eiro, N., Miranda, M.-A., Cid, S., Gonzalez, L. O., Dominguez, F., Vizoso, F. J. Tags: Original Manuscript Source Type: research
Breast cancer cells compete with hematopoietic stem and progenitor cells for intercellular adhesion molecule 1-mediated binding to the bone marrow microenvironment
Adhesion-based cellular interactions involved in breast cancer metastasis to the bone marrow remain elusive. We identified that breast cancer cells directly compete with hematopoietic stem and progenitor cells (HSPCs) for retention in the bone marrow microenvironment. To this end, we established two models of competitive cell adhesion—simultaneous and sequential—to study a potential competition for homing to the niche and displacement of the endogenous HSPCs upon invasion by tumor cells. In both models, breast cancer cells but not non-tumorigenic cells competitively reduced adhesion of HSPCs to bone marrow-deri...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Dhawan, A., Friedrichs, J., Bonin, M. v., Bejestani, E. P., Werner, C., Wobus, M., Chavakis, T., Bornhäuser, M. Tags: Original Manuscript Source Type: research
Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)
The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated microsatellite-stable hereditary non-polyposis CRC (MSS HNPCC) cases. Selected genetic variants were genotyped in a discovery set of 27 MSS HNPCC cases and 85 controls. One genetic variant, rs67687202, in TGFBR1 emerged as significant (P = 0.002), and it was genotyped in a replication set of 87 additional MSS HNPCC-like cases and 338 controls where it was also significantly ...
Source: Carcinogenesis - July 29, 2016 Category: Cancer & Oncology Authors: Xicola, R. M., Bontu, S., Doyle, B. J., Rawson, J., Garre, P., Lee, E., de la Hoya, M., Bessa, X., Clofent, J., Bujanda, L., Balaguer, F., Castellvi-Bel, S., Alenda, C., Jover, R., Ruiz-Ponte, C., Syngal, S., Andreu, M., Carracedo, A., Castells, A., Newco Tags: Original Manuscript Source Type: research
