Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity
DNA hypomethylation was previously implicated in cancer progression and metastasis. The purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene thought to exert anticancer effects, target genes with oncogenic function for de novo methylation and silencing, leading to inactivation of related signaling pathways. Following Illumina 450K, genome-wide DNA methylation analysis reveals that stilbenoids alter DNA methylation patterns in breast cancer cells. On average, 75% of differentially methylated genes have increased methylation, and these genes are enriched for oncogenic functions, including N...
Source: Carcinogenesis - July 6, 2016 Category: Cancer & Oncology Authors: Lubecka, K., Kurzava, L., Flower, K., Buvala, H., Zhang, H., Teegarden, D., Camarillo, I., Suderman, M., Kuang, S., Andrisani, O., Flanagan, J. M., Stefanska, B. Tags: Original Manuscript Source Type: research
Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells
Aristolochic acids (AA) are implicated in the development of chronic renal disease and upper urinary tract carcinoma in humans. Using in vitro approaches, we demonstrated that N-hydroxyaristolactams, metabolites derived from partial nitroreduction of AA, require sulfotransferase (SULT)-catalyzed conjugation with a sulfonyl group to form aristolactam-DNA adducts. Following up on this observation, bioactivation of AA-I and N-hydroxyaristolactam I (AL-I-NOH) was studied in human kidney (HK-2) and skin fibroblast (GM00637) cell lines. Pentachlorophenol, a known SULT inhibitor, significantly reduced cell death and aristolactam-...
Source: Carcinogenesis - July 6, 2016 Category: Cancer & Oncology Authors: Hashimoto, K., Zaitseva, I. N., Bonala, R., Attaluri, S., Ozga, K., Iden, C. R., Johnson, F., Moriya, M., Grollman, A. P., Sidorenko, V. S. Tags: Original Manuscript Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - July 6, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Carcinogenesis)
Source: Carcinogenesis - July 6, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - July 6, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - July 6, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - July 6, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - July 6, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Corrigendum
(Source: Carcinogenesis)
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Tags: Corrigendum Source Type: research
Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats
This study demonstrated that fecal water of hemoglobin- and beef-fed rats preferentially induced apoptosis in mouse normal colon epithelial cells than in those carrying mutation on Apc (Adenomatous polyposis coli) gene, considered as preneoplastic. Highlighting the importance of lipid peroxidation and neoformation of secondary aldehydes like 4-hydroxy-2-nonenal (HNE), we optimized the depletion of carbonyl compounds in the fecal water which turned out to abolish the differential apoptosis in both cell lines. To explain the resistance of preneoplastic cells towards fecal water toxicity, we focused on Nrf2, known to be activ...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Surya, R., Helies-Toussaint, C., Martin, O. C., Gauthier, T., Gueraud, F., Tache, S., Naud, N., Jouanin, I., Chantelauze, C., Durand, D., Joly, C., Pujos-Guillot, E., Pierre, F. H., Huc, L. Tags: Original Manuscript Source Type: research
Oral intake of ranitidine increases urinary excretion of N-nitrosodimethylamine
The H2-receptor antagonist, ranitidine, is among the most widely used pharmaceuticals to treat gastroesophageal reflux disease and peptic ulcers. While previous studies have demonstrated that amines can form N-nitrosamines when exposed to nitrite at stomach-relevant pH, N-nitrosamine formation from ranitidine, an amine-based pharmaceutical, has not been demonstrated under these conditions. In this work, we confirmed the production of N-nitrosodimethylamine (NDMA), a potent carcinogen, by nitrosation of ranitidine under stomach-relevant pH conditions in vitro. We also evaluated the urinary NDMA excretion attributable to ing...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Zeng, T., Mitch, W. A. Tags: Original Manuscript Source Type: research
The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice
This study investigated the protective role of ASA in azoxymethane (AOM)-initiated and dextran sulfate sodium (DSS)-promoted colitis-associated colon cancer (CAC) and examined the epigenetic effects, particularly on histone 3 lysine 27 acetylation (H3K27ac), underlying the preventive effect of ASA. CF-1 mice were fed with AIN-93M diet with or without 0.02% ASA from 1 week prior to AOM initiation until the mice were killed 20 weeks after AOM injection. Our results showed that AOM/DSS + ASA significantly suppressed inflammatory colitis symptoms and tumor multiplicity. AOM/DSS + ASA reduced AOM/DSS-induced protein expression ...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Guo, Y., Liu, Y., Zhang, C., Su, Z.-Y., Li, W., Huang, M.-T., Kong, A.-N. Tags: Original Manuscript Source Type: research
A case-control analysis of smoking and breast cancer in African American women: findings from the AMBER Consortium
Recent population studies suggest a role of smoking in the etiology of breast cancer, but few have been conducted among African American women. In a collaborative project of four large studies, we examined associations between smoking measures and breast cancer risk by menopause and hormone receptor status [estrogen receptor-positive (ER+), ER-negative (ER–) and triple-negative (ER–, PR–, HER2–)]. The study included 5791 African American women with breast cancer and 17376 African American controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in multivariable logistic regress...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Park, S.-Y., Palmer, J. R., Rosenberg, L., Haiman, C. A., Bandera, E. V., Bethea, T. N., Troester, M. A., Viscidi, E., Kolonel, L. N., Olshan, A. F., Ambrosone, C. B. Tags: Original Manuscript Source Type: research
Can supplementation of phytoestrogens/insoluble fibers help the management of duodenal polyps in familial adenomatous polyposis?
In conclusion, ADI proved to be safe and effective, and its long-term effects on FAP patients need further investigation. Judging from the results we observed on COX-2 and miR-101 expression, the short-term effects of ADI treatment could be comparable with those obtained using COX-2 inhibitors, with the advantage of being much more tolerable in chronic therapies and void of adverse events. (Source: Carcinogenesis)
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Calabrese, C., Rizzello, F., Gionchetti, P., Calafiore, A., Pagano, N., De Fazio, L., Valerii, M. C., Cavazza, E., Strillacci, A., Comelli, M. C., Poggioli, G., Campieri, M., Spisni, E. Tags: Original Manuscript Source Type: research
Beneficial effects of the naturally occurring flavonoid silibinin on the prostate cancer microenvironment: role of monocyte chemotactic protein-1 and immune cell recruitment
Tumor microenvironment plays an essential role in prostate carcinogenesis and offers novel opportunities to prevent and treat prostate cancer (PCA). Here, we investigated the ability of cancer-associated fibroblasts (CAFs) to promote PCA progression, and silibinin efficacy to target this response. We collected conditioned media from CAFs treated with vehicle or silibinin, and labeled as control conditioned media (CCM) or silibinin-treatment conditioned media (SBCM), respectively. Next, we characterized the effect of CCM and SBCM treatment in several PCA cell lines (RWPE-1, WPE-1 NA-22, WPE-1 NB-14 and PC3). Result showed t...
Source: Carcinogenesis - May 22, 2016 Category: Cancer & Oncology Authors: Ting, H., Deep, G., Kumar, S., Jain, A. K., Agarwal, C., Agarwal, R. Tags: Original Manuscript Source Type: research
