Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer
Colorectal cancer (CRC) is characterized by specific patterns of copy number alterations (CNAs), which helped with the identification of driver oncogenes and tumor suppressor genes (TSGs). More recently, the usage of single nucleotide polymorphism arrays provided information of copy number neutral loss of heterozygosity, thus suggesting the occurrence of somatic uniparental disomy (UPD) and uniparental polysomy (UPP) events. The aim of this study is to establish an integrative profiling of recurrent UPDs/UPPs and CNAs in sporadic CRC. Our results indicate that regions showing high frequencies of UPD/UPP mostly coincide wit...
Source: Carcinogenesis - September 30, 2015 Category: Cancer & Oncology Authors: Torabi, K., Miro, R., Fernandez-Jimenez, N., Quintanilla, I., Ramos, L., Prat, E., del Rey, J., Pujol, N., Killian, J. K., Meltzer, P. S., Fernandez, P. L., Ried, T., Lozano, J. J., Camps, J., Ponsa, I. Tags: Original Manuscript Source Type: research
PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome
Although PIWI-interacting RNAs (piRNAs) account for the largest class of the small non-coding RNA superfamily, virtually nothing is known of their function in human carcinogenesis. Once thought to be expressed solely in the germ line where they safeguard the genome against transposon-induced insertional mutations, piRNAs are now believed to play an active role in somatic gene regulation through sequence-specific histone modification and DNA methylation. In the current study, we investigate the role of piRNA-021285 (piR-021285) in the regulation of the breast cancer methylome. Genotypic screening of a panel of single-nucleo...
Source: Carcinogenesis - September 30, 2015 Category: Cancer & Oncology Authors: Fu, A., Jacobs, D. I., Hoffman, A. E., Zheng, T., Zhu, Y. Tags: Original Manuscript Source Type: research
Immunosuppression associated with chronic inflammation in the tumor microenvironment
Chronic inflammation contributes to cancer development via multiple mechanisms. One potential mechanism is that chronic inflammation can generate an immunosuppressive microenvironment that allows advantages for tumor formation and progression. The immunosuppressive environment in certain chronic inflammatory diseases and solid cancers is characterized by accumulation of proinflammatory mediators, infiltration of immune suppressor cells and activation of immune checkpoint pathways in effector T cells. In this review, we highlight recent advances in our understanding of how immunosuppression contributes to cancer and how pro...
Source: Carcinogenesis - September 30, 2015 Category: Cancer & Oncology Authors: Wang, D., DuBois, R. N. Tags: Review Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - September 30, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - September 30, 2015 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
