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(Source: Carcinogenesis)
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - September 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Dietary flavonoid fisetin increases abundance of high-molecular-mass hyaluronan conferring resistance to prostate oncogenesis
We and others have shown previously that fisetin, a plant flavonoid, has therapeutic potential against many cancer types. Here, we examined the probable mechanism of its action in prostate cancer (PCa) using a global metabolomics approach. HPLC–ESI–MS analysis of tumor xenografts from fisetin-treated animals identified several metabolic targets with hyaluronan (HA) as the most affected. Efficacy of fisetin on HA was then evaluated in vitro and also in vivo in the transgenic TRAMP mouse model of PCa. Size exclusion chromatography-multiangle laser light scattering (SEC-MALS) was performed to analyze the molar mas...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Lall, R. K., Syed, D. N., Khan, M. I., Adhami, V. M., Gong, Y., Lucey, J. A., Mukhtar, H. Tags: Original Manuscript Source Type: research
Serum 5-LOX: a progressive protein marker for breast cancer and new approach for therapeutic target
This study evaluated the serum level of 5-LOX in breast cancer patients and its in vitro inhibition assessment with peptide inhibitor YWCS. The level of 5-LOX was determined by surface plasmon resonance (SPR). The peptide inhibitor of 5-LOX was designed by molecular modeling and kinetic assay was performed by spectrophotometry. The siRNA mediated 5-LOX gene silencing was performed to investigate the effect on proliferation of MDA-MB-231, breast cancer cell line. The serum 5-LOX level in breast cancer (5.69±1.97ng/µl) was almost 2-fold elevated compared to control (3.53±1.0ng/µl) (P < 0.0001). T...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Kumar, R., Singh, A. K., Kumar, M., Shekhar, S., Rai, N., Kaur, P., Parshad, R., Dey, S. Tags: Original Manuscript Source Type: research
Association of lifestyle and demographic factors with estrogenic and glucocorticogenic activity in Mexican American women
Breast cancer risk is higher in US-born than in foreign-born Hispanics/Latinas and also increases with greater length of US residency. It is only partially known what factors contribute to these patterns of risk. To gain new insights, we tested the association between lifestyle and demographic variables and breast cancer status, with measures of estrogenic (E) and glucocorticogenic (G) activity in Mexican American women. We used Chemical-Activated LUciferase gene eXpression assays to measure E and G activity in total plasma from 90 Mexican American women, without a history of breast cancer at the time of recruitment, from ...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Fejerman, L., Sanchez, S. S., Thomas, R., Tachachartvanich, P., Riby, J., Gomez, S. L., John, E. M., Smith, M. T. Tags: Original Manuscript Source Type: research
Pre-diagnostic leukocyte mitochondrial DNA copy number and skin cancer risk
We examined the associations between peripheral blood leukocytes mtCN level and the risks of skin cancers in a case–control study nested within the Nurses’ Health Study of non-Hispanic White women, including 272 melanoma cases and 293 controls, 508 squamous cell carcinoma (SCC) cases and 550 controls, and 515 basal cell carcinoma (BCC) cases and 536 controls. Relative mtCN in peripheral blood leukocytes was measured by quantitative PCR-based assay. Unconditional logistic regression models were used to examine the associations between mtCN and skin cancer risks. Compared with those with high mtCN, the risk for m...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Meng, S., De Vivo, I., Liang, L., Giovannucci, E., Tang, J. Y., Han, J. Tags: Original Manuscript Source Type: research
Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium
DNA repair pathways maintain genomic integrity and stability, and dysfunction of DNA repair leads to cancer. We hypothesize that functional genetic variants in DNA repair genes are associated with risk of lung cancer. We performed a large-scale meta-analysis of 123,371 single nucleotide polymorphisms (SNPs) in 169 DNA repair genes obtained from six previously published genome-wide association studies (GWASs) of 12160 lung cancer cases and 16838 controls. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) using the logistic regression model and used the false discovery rate (FDR) method for correction of mu...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Wang, M., Liu, H., Liu, Z., Yi, X., Bickeboller, H., Hung, R. J., Brennan, P., Landi, M. T., Caporaso, N., Christiani, D. C., Doherty, J. A., The TRICL Research Team, Amos, C. I., Wei, Q. Tags: Original Manuscript Source Type: research
Stromal VCAN expression as a potential prognostic biomarker for disease recurrence in stage II-III colon cancer
To develop prognostic biomarkers that can discriminate stage II–III colorectal cancer patients with high risk of postoperative recurrence, we conducted a genome-wide screening of relapse-related genes utilizing multiple microarray cohorts. Among differentially expressed genes between tumor and nontumor, we identified eight candidate genes associated with relapse in two datasets of stage II–III patients (n = 94 and 145, respectively, P < 0.05). Using datasets of laser-microdissected samples and FACS-purified cell populations, the localization of candidate genes, including COL4A2, COL4A1, VCAN and SERPINE1, we...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Chida, S., Okayama, H., Noda, M., Saito, K., Nakajima, T., Aoto, K., Hayase, S., Momma, T., Ohki, S., Kono, K., Takenoshita, S. Tags: Original Manuscript Source Type: research
An exome-wide analysis of low frequency and rare variants in relation to risk of breast cancer in African American Women: the AMBER Consortium
A large percentage of breast cancer heritability remains unaccounted for, and most of the known susceptibility loci have been established in European and Asian populations. Rare variants may contribute to the unexplained heritability of this disease, including in women of African ancestry (AA). We conducted an exome-wide analysis of rare variants in relation to risk of overall and subtype-specific breast cancer in the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium, which includes data from four large studies of AA women. Genotyping on the Illumina Human Exome Beadchip yielded data for 170 812 SNPs ...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Haddad, S. A., Ruiz-Narvaez, E. A., Haiman, C. A., Sucheston-Campbell, L. E., Bensen, J. T., Zhu, Q., Liu, S., Yao, S., Bandera, E. V., Rosenberg, L., Olshan, A. F., Ambrosone, C. B., Palmer, J. R., Lunetta, K. L. Tags: Original Manuscript Source Type: research
miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma
miR-200b is a pleiotropically acting microRNA in cancer progression, representing an attractive therapeutic target. We previously identified miR-200b as an invasiveness repressor in esophageal squamous cell carcinoma (ESCC), whereas further understanding is warranted to establish it as a therapeutic target. Here, we show that miR-200b mitigates ESCC cell growth by inducing G2-phase cell cycle arrest and apoptosis. The expression/activation of multiple key cell cycle regulators such as CDK1, CDK2, CDK4 and Cyclin B, and the Wnt/β-Catenin signaling are modulated by miR-200b. We identified CDK2 and PAF (PCNA-associated f...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Zhang, H.-F., Alshareef, A., Wu, C., Jiao, J.-W., Sorensen, P. H., Lai, R., Xu, L.-Y., Li, E.-M. Tags: Original Manuscript Source Type: research
Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients
Single nucleotide polymorphisms (SNPs) in microRNA genes have been associated with colorectal cancer (CRC) risk, survival and response to treatment. Conflicting results are available on the association between rs4919510, a SNP in mature miR-608 and clinical outcome in CRC. Here, we analyzed the association between rs4919510 and benefit from perioperative treatment in a randomised phase II trial of neoadjuvant Capecitabine and Oxaliplatin (CAPOX) followed by chemo-radiotherapy, surgery and adjuvant CAPOX ± Cetuximab in high-risk locally advanced rectal cancer (LARC). A total of 155/164 (94.5%) patients were assessabl...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Sclafani, F., Chau, I., Cunningham, D., Lampis, A., Hahne, J. C., Ghidini, M., Lote, H., Zito, D., Tabernero, J., Glimelius, B., Cervantes, A., Begum, R., De Castro, D. G., Wilson, S. H., Peckitt, C., Eltahir, Z., Wotherspoon, A., Tait, D., Brown, G., Oat Tags: Original Manuscript Source Type: research
Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1
Microglia play important roles in extracellular matrix remodeling, tumor invasion, angiogenesis, and suppression of adaptive immunity in glioma. Na+/H+ exchanger isoform 1 (NHE1) regulates microglial activation and migration. However, little is known about the roles of NHE1 in intratumoral microglial activation and microglia–glioma interactions. Our study revealed up-regulation of NHE1 protein expression in both glioma cells and tumor-associated Iba1+ microglia in glioma xenografts and glioblastoma multiforme microarrays. Moreover, we observed positive correlation of NHE1 expression with Iba1 intensity in microglia/m...
Source: Carcinogenesis - August 31, 2016 Category: Cancer & Oncology Authors: Zhu, W., Carney, K. E., Pigott, V. M., Falgoust, L. M., Clark, P. A., Kuo, J. S., Sun, D. Tags: Original Manuscript Source Type: research
