Unraveling the links between cancer and aging
Aging is, by far, the most important risk factor for cancer; however, only very recently the mechanistic links between these two processes are beginning to emerge. To approach the connection between aging and cancer, it is helpful to re-phrase the link as follows: the best protection against cancer is to be young. Therefore, longevity genes and longevity interventions should be cancer protecting. (Source: Carcinogenesis)
Source: Carcinogenesis - February 8, 2016 Category: Cancer & Oncology Authors: Serrano, M. Tags: Star Review Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - February 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Carcinogenesis)
Source: Carcinogenesis - February 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - February 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - February 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - February 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - February 8, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci
This study represents a significant advance over previous research by investigating a large number of novel, rare variants, as well as their underlying mechanisms through telomere length. Variants for this fine-mapping study were identified through a targeted deep sequencing (average depth of coverage greater than 4000x) of 576 individuals. Subsequently, 4652 SNPs, including 1108 novel SNPs, were genotyped in 5164 cases and 5716 controls of European ancestry. After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P ...
Source: Carcinogenesis - January 5, 2016 Category: Cancer & Oncology Authors: Kachuri, L., Amos, C. I., McKay, J. D., Johansson, M., Vineis, P., Bueno-de-Mesquita, H. B., Boutron-Ruault, M.-C., Johansson, M., Quiros, J. R., Sieri, S., Travis, R. C., Weiderpass, E., Le Marchand, L., Henderson, B. E., Wilkens, L., Goodman, G. E., Che Tags: Original Manuscript Source Type: research
Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis
Genome-wide association studies have identified several germline single nucleotide polymorphisms (SNPs) significantly associated with colorectal cancer (CRC) incidence. Common germline genetic variation may also be related to CRC survival. We used a discovery-based approach to identify SNPs related to survival outcomes after CRC diagnosis. Genome-wide genotyping arrays were conducted for 3494 individuals with invasive CRC enrolled in six prospective cohort studies (median study-specific follow-up = 4.2–8.1 years). In pooled analyses, we used Cox regression to assess SNP-specific associations with CRC-specific and ove...
Source: Carcinogenesis - January 5, 2016 Category: Cancer & Oncology Authors: Phipps, A. I., Passarelli, M. N., Chan, A. T., Harrison, T. A., Jeon, J., Hutter, C. M., Berndt, S. I., Brenner, H., Caan, B. J., Campbell, P. T., Chang-Claude, J., Chanock, S. J., Cheadle, J. P., Curtis, K. R., Duggan, D., Fisher, D., Fuchs, C. S., Gala, Tags: Original Manuscript Source Type: research
The presence of the intron 3 16 bp duplication polymorphism of p53 (rs17878362) in breast cancer is associated with a low {Delta}40p53:p53 ratio and better outcome
This study aimed to determine if rs17878362 was associated with altered 40p53 and p53 expression and outcome in breast cancer. We sequenced p53 in breast tumours from 139 patients and compared this with 40p53 and p53 mRNA expression. We found that the ratio of 40p53:p53 was significantly lower in tumours homozygous for the polymorphic A2 allele compared with those who were wild-type (A1/A1). Furthermore, there was a lower proportion of breast cancers carrying the A2 allele from patients who subsequently developed metastasis compared with those that did not. Finally, we show that patients whose tumours carried the polymorph...
Source: Carcinogenesis - January 5, 2016 Category: Cancer & Oncology Authors: Morten, B. C., Wong-Brown, M. W., Scott, R. J., Avery-Kiejda, K. A. Tags: Original Manuscript Source Type: research
Genetic deletion of TNF{alpha} inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKC{varepsilon} transgenic mice via inhibition of cell survival signals
Protein kinase C epsilon (PKC), a Ca2+-independent phospholipid-dependent serine/threonine kinase, is among the six PKC isoforms (α, , , , μ, ) expressed in both mouse and human skin. Epidermal PKC level dictates the susceptibility of PKC transgenic (TG) mice to the development of cutaneous squamous cell carcinomas (SCC) elicited either by repeated exposure to ultraviolet radiation (UVR) or by using the DMBA initiation-TPA (12-O-tetradecanoylphorbol-13-acetate) tumor promotion protocol (Wheeler,D.L. et al. (2004) Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced ...
Source: Carcinogenesis - January 5, 2016 Category: Cancer & Oncology Authors: Singh, A., Singh, A., Bauer, S. J., Wheeler, D. L., Havighurst, T. C., Kim, K., Verma, A. K. Tags: Original Manuscript Source Type: research
Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers
In this study, we have evaluated RECQL5 mRNA expression in 1977 breast cancers, and RECQL5 protein level in 1902 breast cancers [Nottingham Tenovus series (n = 1650) and ER– cohort (n = 252)]. Expression levels were correlated to aggressive phenotypes and survival outcomes. High RECQL5 mRNA expression was significantly associated with high histological grade (P = 0.007), HER2 overexpression (P = 0.032), ER+/HER2–/high proliferation genefu subtype (P < 0.0001), integrative molecular clusters (intClust 1and 9) (P < 0.0001) and poor survival (P < 0.0001). In subgroup analysis, high RECQL5 mRNA level remai...
Source: Carcinogenesis - January 5, 2016 Category: Cancer & Oncology Authors: Arora, A., Abdel-Fatah, T. M. A., Agarwal, D., Doherty, R., Croteau, D. L., Moseley, P. M., Hameed, K., Green, A., Aleskandarany, M. A., Rakha, E. A., Patterson, K., Ball, G., Chan, S. Y. T., Ellis, I. O., Bohr, V. A., Bryant, H. E., Madhusudan, S. Tags: Original Manuscript Source Type: research
FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks
In this study, we purified a flap endonuclease 1 (FEN1) and xeroderma pigmentosum group G protein (XPG) in the 5' to 3' structure-specific DNA endonuclease family and synthesized single-strand break DNA substrates containing a 5'-phoshotyrosyl bond, mimicking the Top2–SSB complex. We found that FEN1 and XPG did not remove the 5'-phoshotyrosyl bond-containing DSB substrates but removed the 5'-phoshotyrosyl bond-containing SSB substrates. Under DNA repair conditions, FEN1 efficiently repaired the 5'-phoshotyrosyl bond-containing SSB substrates in the presence of DNA ligase and DNA polymerase. Therefore, FEN1 may play a...
Source: Carcinogenesis - January 5, 2016 Category: Cancer & Oncology Authors: Kametani, Y., Takahata, C., Narita, T., Tanaka, K., Iwai, S., Kuraoka, I. Tags: Original Manuscript Source Type: research
Genetic variants in the mTOR pathway and breast cancer risk in African American women
In conclusion, specific mTOR pathway genes are potentially important to breast cancer risk and to the ER negativity in African American women. (Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2016 Category: Cancer & Oncology Authors: Cheng, T.-Y. D., Ambrosone, C. B., Hong, C.-C., Lunetta, K. L., Liu, S., Hu, Q., Yao, S., Sucheston-Campbell, L., Bandera, E. V., Ruiz-Narvaez, E. A., Haddad, S., Troester, M. A., Haiman, C. A., Bensen, J. T., Olshan, A. F., Palmer, J. R., Rosenberg, L. Tags: Original Manuscript Source Type: research
Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress
Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Mutations in human homologue MDR3 are associated with several liver diseases. Knockout of Mdr2 results in hepatic inflammation, liver fibrosis and hepatocellular carcinoma (HCC). Whereas the pathogenesis in Mdr2 –/– mice has been largely attributed to the toxicity of bile acids due to the absence of PC in the bile, the question of whether Mdr2 deficiency per se perturb...
Source: Carcinogenesis - January 5, 2016 Category: Cancer & Oncology Authors: Tebbi, A., Levillayer, F., Jouvion, G., Fiette, L., Soubigou, G., Varet, H., Boudjadja, N., Cairo, S., Hashimoto, K., Suzuki, A. M., Carninci, P., Carissimo, A., di Bernardo, D., Wei, Y. Tags: Original Manuscript Source Type: research
