The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: an effect mediated by cyclin D1
Given that glioblastoma multiforme (GBM) is associated with poor prognosis, new agents are urgently needed. We developed phospho-glycerol-ibuprofen-amide (PGIA), a novel ibuprofen derivative, and evaluated its safety and efficacy in preclinical models of GBM, and its mechanism of action using human GBM cells and animal tumor models. Furthermore, we explored whether formulating PGIA in polymeric nanoparticles could enhance its levels in the brain. PGIA was 3.7- to 5.1-fold more potent than ibuprofen in suppressing the growth of human GBM cell lines. PGIA 0.75x IC50 inhibited cell proliferation by 91 and 87% in human LN-229 ...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Bartels, L. E., Mattheolabakis, G., Vaeth, B. M., LaComb, J. F., Wang, R., Zhi, J., Komninou, D., Rigas, B., Mackenzie, G. G. Tags: Original Manuscript Source Type: research
Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a heterogeneous disease in which tumor subtypes can be identified based on the presence of adult liver progenitor cells. Having previously identified the mTOR pathway as critical to progenitor cell proliferation in a model of liver injury, we investigated the temporal activation of mTOR signaling in a rat model of hepatic carcinogenesis. The model employed chemical carcinogens and partial hepatectomy to induce progenitor marker-positive HCC. Immunohistochemical staining for phosphorylated ribosomal protein S6 indicated robust mTOR complex 1 (mTORC1) activity in early preneoplastic lesions ...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Francois-Vaughan, H., Adebayo, A. O., Brilliant, K. E., Parry, N. M. A., Gruppuso, P. A., Sanders, J. A. Tags: Original Manuscript Source Type: research
PAQR3 enhances Twist1 degradation to suppress epithelial-mesenchymal transition and metastasis of gastric cancer cells
In this study, we demonstrate that PAQR3 is actively involved in the degradation of Twist1 and whereby regulates EMT and metastasis of gastric cancer cells. PAQR3 overexpression reduces the protein level but not the mRNA level of Twist1. The protein stability and polyubiquitination of Twist1 are altered by PAQR3. PAQR3 forms a complex with Twist1 and BTRC, an E3 ubiquitin ligase. PAQR3 enhances the interaction between Twist1 and BTRC. Twist1 is mobilized from the nucleus to a proteasome-containing structure in the cytoplasm upon overexpression of PAQR3 and BTRC, which is required for PAQR3-induced degradation of Twist1. Th...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Guo, W., You, X., Xu, D., Zhang, Y., Wang, Z., Man, K., Wang, Z., Chen, Y. Tags: Original Manuscript Source Type: research
An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis
This study explored its role as an anticancer agent. The AR seed extract (AR extract) inhibited proliferation and colony formation in a dose- and time-dependent manner and promoted apoptosis as was evidenced by cleavage of PARP and increased expression of Bax accompanying reduced levels of BCL-xl protein in HCT116 and SW480 cells, respectively. In addition, AR extract-arrested cells at Go/G1 phase of cell cycle and exhibited decreases in Cyclin D1. AR extract-treated cells exhibited reduced number and size of colonospheres in a dose-dependent manner concomitant with decreases in cancer stem cell (CSC) markers ALDH1A1 and D...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Ahmed, I., Roy, B. C., Subramaniam, D., Ganie, S. A., Kwatra, D., Dixon, D., Anant, S., Zargar, M. A., Umar, S. Tags: Original Manuscript Source Type: research
Adolescent dietary patterns and premenopausal breast cancer incidence
Mammary tissue experiences the highest rate of proliferation during adolescence representing a period of heightened susceptibility. Few prospective studies have examined adolescent diet and breast cancer, and none have examined dietary patterns. Thus, we examined the association between adolescent dietary patterns and a diet quality index, the Alternative Healthy Eating Index (AHEI), and breast cancer in the Nurses’ Health Study II among those who completed a 124-item food frequency questionnaire about their high-school diet (HS-FFQ). Cox proportional hazards regression models were used to calculate hazard ratios (HR...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Harris, H. R., Willett, W. C., Vaidya, R. L., Michels, K. B. Tags: Original Manuscript Source Type: research
Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats
This study evaluated whether dietary resistant starch (RS) and green tea extract (GTE), which have anti-inflammatory and anticancer properties, protect against colitis-associated colorectal cancer (CAC) using a rat model, also investigated potential mechanisms of action of these agents including their effects on the gut microbiota. Rats were fed a control diet or diets containing 10% RS, 0.5% GTE or a combination of the two (RS + GTE). CAC was initiated with 2 weekly azoxymethane (AOM) injections (10mg/kg) followed by 2% dextran sodium sulphate in drinking water for 7 days after 2 weeks on diets. Rats were killed 20 weeks ...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Hu, Y., Le Leu, R. K., Christophersen, C. T., Somashekar, R., Conlon, M. A., Meng, X. Q., Winter, J. M., Woodman, R. J., McKinnon, R., Young, G. P. Tags: Original Manuscript Source Type: research
Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
The incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. Although survival has improved, cure rates remain poor, with <20% of patients surviving 5 years. This is the first study to explore methylome, transcriptome and ENCODE data to characterize the role of methylation in EAC. We investigate the genome-wide methylation profile of 250 samples including 125 EAC, 19 Barrett’s esophagus (BE), 85 squamous esophagus and 21 normal stomach. Transcriptome data of 70 samples (48 EAC, 4 BE and 18 squamous esophagus) were used to identify changes in methylation associated with gene express...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Krause, L., Nones, K., Loffler, K. A., Nancarrow, D., Oey, H., Tang, Y. H., Wayte, N. J., Patch, A. M., Patel, K., Brosda, S., Manning, S., Lampe, G., Clouston, A., Thomas, J., Stoye, J., Hussey, D. J., Watson, D. I., Lord, R. V., Phillips, W. A., Gotley, Tags: Original Manuscript Source Type: research
Regulation of the MET oncogene: molecular mechanisms
The MET oncogene is a predictive biomarker and an attractive therapeutic target for various cancers. Its expression is regulated at multiple layers via various mechanisms. It is subject to epigenetic modifications, i.e. DNA methylation and histone acetylation. Hypomethylation and acetylation of the MET gene have been associated with its high expression in some cancers. Multiple transcription factors including Sp1 and Ets-1 govern its transcription. After its transcription, MET mRNA is spliced into multiple species in the nucleus before being transported to the cytoplasm where its translation is modulated by at least 30 mic...
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Authors: Zhang, J., Babic, A. Tags: Review Source Type: research
Table_of_Contents
(Source: Carcinogenesis)
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: Carcinogenesis)
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Instructions_to_Authors
(Source: Carcinogenesis)
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Front_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Back_Cover
(Source: Carcinogenesis)
Source: Carcinogenesis - March 23, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Erratum
(Source: Carcinogenesis)
Source: Carcinogenesis - February 24, 2016 Category: Cancer & Oncology Tags: Erratum Source Type: research
