Editorial_Board
(Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - January 5, 2017 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
Editor-in-Chiefs Note - Thank you to Reviewers
(Source: Carcinogenesis)
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Tags: List of referees Source Type: research
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability
LPIN1 is a protein that exhibits dual functions as a phosphatidic acid phosphatase enzyme in regulation of triglyceride and glycerophospholipid metabolism and a transcriptional coregulator. Through unknown tumour-promoting mechanism, LPIN1 frequently observed in various human cancer cell lines controls main cellular processes involved in cancer progression. Here, we demonstrate that LPIN1 enhances the tumour-promoting function of insulin receptor substrate 1 (IRS1) by controlling IRS1 stability. LPIN1 interacts with IRS1 in an insulin growth factor-1-dependent signalling pathway and inhibits its serine phosphorylation, and...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Kim, J. Y., Kim, G., Lim, S.-C., Choi, H. S. Tags: Original Manuscript Source Type: research
Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice
A novel Helicobacter species Helicobacter japonicum was isolated from the stomach and intestines of clinically normal mice received from three institutes from Japan. The novel Helicobacter sp. was microaerobic, grew at 37°C and 42°C, was catalase and oxidase positive, but urease negative. It is most closely related to the 16S rRNA gene of H.muridarum (98.6%); to the 23S rRNA gene of H.hepaticus (97.9%); to the hsp60 gene of H.typhlonius (87%). The novel Helicobacter sp. has in vitro cytolethal distending toxin (CDT) activity; its cdtB gene sequence has 83.8% identity with that of H.hepaticus. The whole genome seque...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Shen, Z., Feng, Y., Muthupalani, S., Sheh, A., Cheaney, L. E., Kaufman, C. A., Gong, G., Paster, B. J., Fox, J. G. Tags: Original Manuscript Source Type: research
Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer
Recent data from The Cancer Genome Atlas analysis have revealed that Aurora kinase A (AURKA) amplification and overexpression characterize a distinct subset of human tumors across multiple cancer types. Although elevated expression of AURKA has been shown to induce oncogenic phenotypes in cells in vitro, findings from transgenic mouse models of Aurora-A overexpression in mammary glands have been distinct depending on the models generated. In the present study, we report that prolonged overexpression of AURKA transgene in mammary epithelium driven by ovine β-lactoglobulin promoter, activated through multiple pregnancy ...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Treekitkarnmongkol, W., Katayama, H., Kai, K., Sasai, K., Jones, J. C., Wang, J., Shen, L., Sahin, A. A., Gagea, M., Ueno, N. T., Creighton, C. J., Sen, S. Tags: Original Manuscript Source Type: research
The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer
Because the 5-year survival rate for pancreatic cancer remains under 10%, new drugs are needed for the prevention and treatment of this devastating disease. Patients with chronic pancreatitis have a 12-fold higher risk of developing pancreatic cancer. LSL-KrasG12D/+;Pdx-1-Cre (KC) mice replicate the genetics, symptoms and histopathology found in human pancreatic cancer. Immune cells infiltrate into the pancreas of these mice and produce inflammatory cytokines that promote tumor growth. KC mice are particularly sensitive to the effects of lipopolysaccharide (LPS), as only 48% of KC mice survived an LPS challenge while 100% ...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Leal, A. S., Sporn, M. B., Pioli, P. A., Liby, K. T. Tags: Original Manuscript Source Type: research
Prevention of DNA damage in Barretts esophageal cells exposed to acidic bile salts
In this study, we investigated DNA damage in BE cells exposed to acidic bile salts and explored for potential protective strategies. Exposure of BE cells to acidic bile salts led to significant DNA damage, which in turn, was due to generation of reactive oxygen species (ROS). We found that acidic bile salts induce a rapid increase in superoxide radicals and hydrogen peroxide, which were determined using electron paramagnetic resonance spectroscopy and Amplex Red assay. Analyzing a panel of natural antioxidants, we identified apocynin to be the most effective in protecting esophageal cells from DNA damage induced by acidic ...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Bhardwaj, V., Horvat, A., Korolkova, O., Washington, M. K., El-Rifai, W., Dikalov, S. I., Zaika, A. I. Tags: Original Manuscript Source Type: research
Integration of a radiation biomarker into modeling of thyroid carcinogenesis and post-Chernobyl risk assessment
Strong evidence for the statistical association between radiation exposure and disease has been produced for thyroid cancer by epidemiological studies after the Chernobyl accident. However, limitations of the epidemiological approach in order to explore health risks especially at low doses of radiation appear obvious. Statistical fluctuations due to small case numbers dominate the uncertainty of risk estimates. Molecular radiation markers have been searched extensively to separate radiation-induced cancer cases from sporadic cases. The overexpression of the CLIP2 gene is the most promising of these markers. It was found in...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Kaiser, J. C., Meckbach, R., Eidemüller, M., Selmansberger, M., Unger, K., Shpak, V., Blettner, M., Zitzelsberger, H., Jacob, P. Tags: Original Manuscript Source Type: research
Exposure to polychlorinated biphenyls and prostate cancer: population-based prospective cohort and experimental studies
Polychlorinated biphenyls (PCBs) are highly persistent environmental pollutants and are undesirable components of our daily food. PCBs are classified as human carcinogens, but the evidence for prostate cancer is limited and available data are inconsistent. We explored the link between non-dioxin-like PCB and grade of prostate cancer in a prospective cohort as well as in cell experiments. A population-based cohort of 32496 Swedish men aged 45–79 years was followed prospectively through 1998–2011, to assess the association between validated estimates of dietary PCB exposure and incidence of prostate cancer by gra...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Ali, I., Julin, B., Glynn, A., Högberg, J., Berglund, M., Johansson, J.-E., Andersson, S.-O., Andren, O., Giovannucci, E., Wolk, A., Stenius, U., Akesson, A. Tags: Original Manuscript Source Type: research
A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma
Animal models have suggested that oral or topical administration of caffeine could inhibit ultraviolet-induced carcinogenesis via the ataxia telangiectasia and rad3 (ATR)-related apoptosis. Previous epidemiological studies have demonstrated that increased caffeine consumption is associated with reduced risk of basal cell carcinoma (BCC). To identify common genetic markers that may modify this association, we tested gene–caffeine intake interaction on BCC risk in a genome-wide analysis. We included 3383 BCC cases and 8528 controls of European ancestry from the Nurses’ Health Study and Health Professionals Follow...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Li, X., Cornelis, M. C., Liang, L., Song, F., De Vivo, I., Giovannucci, E., Tang, J. Y., Han, J. Tags: Original Manuscript Source Type: research
Altered miRNA expression in high-fat diet-induced prostate cancer progression
In conclusion, a substantial number of miRNAs was altered in HFD-induced PCa growth. Specifically, miR-130a was attenuated in HFD-induced PCa progression with MET overexpression. miRNAs thus have implications in the mechanism, prevention and treatment of HFD-induced PCa progression. (Source: Carcinogenesis)
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Nara, T., Narita, S., Mingguo, H., Yoshioka, T., Koizumi, A., Numakura, K., Tsuruta, H., Maeno, A., Saito, M., Inoue, T., Tsuchiya, N., Satoh, S., Habuchi, T. Tags: Original Manuscript Source Type: research
Plasticity of tumor cell invasion: governance by growth factors and cytokines
Tumor cell migration, the basis for metastatic dissemination, is an adaptive process which depends upon coordinated cell interaction with the environment, influencing cell–matrix and cell–cell adhesion, cytoskeletal dynamics and extracellular matrix remodeling. Growth factors and cytokines, released within the reactive tumor microenvironment and their intracellular effector signals strongly impact mechanocoupling functions in tumor cells and thereby control the mode and extent of tumor invasion, including collective and single-cell migration and their interconversions. Besides their role in controlling tumor ce...
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Authors: Odenthal, J., Takes, R., Friedl, P. Tags: Review Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
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(Source: Carcinogenesis)
Source: Carcinogenesis - December 2, 2016 Category: Cancer & Oncology Tags: Cover / Standing Material Source Type: research
