Corrigendum to “Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA” [Tuberculosis 107 (December 2017) 133–136]
In the version of this article initially published the authors omitted a funding source. The correct funding paragraph is as follows. Research reported in this publication was supported in part by NIAID of the National Institutes of Health under award numbers R01AI09918 and R01AI125160, by the Bill and Melinda Gates Foundation, under grant OPP1024038 and by Anacor Pharmaceuticals. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. (Source: Tuberculosis)
Source: Tuberculosis - February 8, 2018 Category: Respiratory Medicine Authors: Matthew B. McNeil, Devon Dennison, Catherine Shelton, Lindsay Flint, Aaron Korkegian, Tanya Parish Source Type: research
Inhibiting HLA-G restores IFN- γ and TNF-α producing T cell in pleural Tuberculosis
Human Leukocyte Antigen-G (HLA-G), a non-classical, class Ib molecule, has been shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity and differentiation by modulating cytokine secretion. Due to its immune-suppressive function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it favours immune evasion of microbes and tumors by inhibiting immune and inflammatory responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G and its receptor Ig-like transcript −2 (ILT-2) in disseminated vs. (Source: Tuberculosis)
Source: Tuberculosis - February 6, 2018 Category: Respiratory Medicine Authors: Abhinav Saurabh, Sushmita Chakraborty, Prabin Kumar, Anant Mohan, Anuj K. Bhatnagar, Narayan Rishi, Dipendra Kumar Mitra Tags: Immunological Aspects Source Type: research
Inhibiting HLA-G restores IFN- γ and TNF-α producing T cell in Pleural Tuberculosis
Human Leukocyte Antigen-G (HLA-G), a non-classical, class Ib molecule, has been shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity and differentiation by modulating cytokine secretion. Due to its immune-suppressive function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it favours immune evasion of microbes and tumors by inhibiting immune and inflammatory responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G and its receptor Ig-like transcript -2 (ILT-2) in disseminated vs. (Source: Tuberculosis)
Source: Tuberculosis - February 6, 2018 Category: Respiratory Medicine Authors: Abhinav Saurabh, Sushmita Chakraborty, Prabin Kumar, Anant Mohan, Anuj K. Bhatnagar, Narayan Rishi, Dipendra Kumar Mitra Tags: Immunological Aspects Source Type: research
Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival
Cholesterol, an essential cellular component in macrophages, is exploited for entry and long-term survival of Mycobacterium inside the host. Cholesterol-deficient macrophages can restrict the cholesterol-dependent entry of Mycobacterium. Rv3499c protein in Mycobacterium has high binding affinity for cholesterol. Rv3499c gene is a part of mce4 operon which is reported to act as cholesterol transport system in mycobacteria. Earlier we reported Rv3499c protein to localise on cell wall and facilitate entry of Mycobacterium inside macrophages. (Source: Tuberculosis)
Source: Tuberculosis - February 3, 2018 Category: Respiratory Medicine Authors: Rajesh Sinha, Pooja Singh, Neeraj k Saini, Ajit Kumar, Rakesh Pathak, Amita Chandolia, Kushal Garima, Gaurav Tyagi, Madhu Chopra, Ashok Kumar Prasad, Hanumantharao G. Raj, Mridula Bose Source Type: research
Evaluation of a synthetic peptide for the detection of anti-Mycobacterium tuberculosis curli pili IgG antibodies in patients with pulmonary tuberculosis
Tuberculosis (TB) remains a serious threat in underdeveloped areas. Mycobacterium tuberculosis curli pili (MTP), a virulence factor, is a potential biomarker for a reliable point of care (POC) test and was evaluated for its ability to react with Immunoglobulin G (IgG) in TB patients. An MTP synthetic peptide in a slot blot assay was used to screen serum/plasma samples (n = 65) in 3 separate cohorts, including 40 TB positive (16 HIV co-infected), 20 TB negative/HIV negative patients and 5 healthy volunteers. (Source: Tuberculosis)
Source: Tuberculosis - February 3, 2018 Category: Respiratory Medicine Authors: Natasha Naidoo, Balakrishna Pillay, Martin Bubb, Alexander Pym, Thamsanqa Chiliza, Kogieleum Naidoo, Thumbi Ndung'u, Victoria O. Kasprowicz, Manormoney Pillay Source Type: research
Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival
Cholesterol, an essential cellular component in macrophages, is exploited for entry and long-term survival of Mycobacterium inside the host. Cholesterol-deficient macrophages can restrict the cholesterol-dependent entry of Mycobacterium. Rv3499c protein in Mycobacterium has high binding affinity for cholesterol. Rv3499c gene is a part of mce4 operon which is reported to act as cholesterol transport system in mycobacteria. Earlier we reported Rv3499c protein to localise on cell wall and facilitate entry of Mycobacterium inside macrophages. (Source: Tuberculosis)
Source: Tuberculosis - February 3, 2018 Category: Respiratory Medicine Authors: Rajesh Sinha, Pooja Singh, Neeraj k Saini, Ajit Kumar, Rakesh Pathak, Amita Chandolia, Kushal Garima, Gaurav Tyagi, Madhu Chopra, Ashok Kumar Prasad, Hanumantharao G. Raj, Mridula Bose Source Type: research
Evaluation of a synthetic peptide for the detection of anti-Mycobacterium tuberculosis curli pili IgG antibodies in patients with pulmonary tuberculosis
Tuberculosis (TB) remains a serious threat in underdeveloped areas. Mycobacterium tuberculosis curli pili (MTP), a virulence factor, is a potential biomarker for a reliable point of care (POC) test and was evaluated for its ability to react with Immunoglobulin G (IgG) in TB patients. An MTP synthetic peptide in a slot blot assay was used to screen serum/plasma samples (n = 65) in 3 separate cohorts, including 40 TB positive (16 HIV co-infected), 20 TB negative/HIV negative patients and 5 healthy volunteers. (Source: Tuberculosis)
Source: Tuberculosis - February 3, 2018 Category: Respiratory Medicine Authors: Natasha Naidoo, Balakrishna Pillay, Martin Bubb, Alexander Pym, Thamsanqa Chiliza, Kogieleum Naidoo, Thumbi Ndung ù, Victoria Kasprowicz, Manormoney Pillay Source Type: research
CXCL10 is overexpressed in active tuberculosis patients compared to M. tuberculosis-exposed household contacts
Variability in clinical outcome of tuberculosis infection is dependent, among other factors, on variation in host immunological response to the infection, which is modulated, in part by genetic variations present in the host. We undertook a study to identify host factors associated with such clinical variability. (Source: Tuberculosis)
Source: Tuberculosis - February 2, 2018 Category: Respiratory Medicine Authors: Chandrika Bhattacharyya, Partha Pratim Majumder, Bhaswati Pandit Source Type: research
Evaluation of nitroxyl donors' effect on mycobacteria
Nitroxyl (HNO) is a highly elusive and reactive molecule. Nitroxyl biological effects and pharmacological potential are becoming increasingly relevant. Mycobacterium tuberculosis infection needs new and more efficient drugs. Reactive Nitrogen and Oxygen Species (RNOS) are key compounds used by the immune system to fight intracellular infections, particularly Mycobacterium tuberculosis. In this context, we analyzed HNO potential to kill mycobacteria.We evaluated the viability and biological response of mycobacteria towards HNO releasing compounds. (Source: Tuberculosis)
Source: Tuberculosis - February 2, 2018 Category: Respiratory Medicine Authors: Jordana Galizia, Mariano Prado Acosta, Estefan ía Urdániz, Marcelo A. Martí, Mariana Piuri Source Type: research
CXCL10 is overexpressed in active tuberculosis patients compared to M. tuberculosis-exposed household contacts
Variability in clinical outcome of tuberculosis infection is dependent, among other factors, on variation in host immunological response to the infection, which is modulated, in part by genetic variations present in the host. We undertook a study to identify host factors associated with such clinical variability. (Source: Tuberculosis)
Source: Tuberculosis - February 2, 2018 Category: Respiratory Medicine Authors: Chandrika Bhattacharyya, Partha Pratim Majumder, Bhaswati Pandit Source Type: research
Evaluation of nitroxyl donors' effect on mycobacteria
Nitroxyl (HNO) is a highly elusive and reactive molecule. Nitroxyl biological effects and pharmacological potential are becoming increasingly relevant. M. tuberculosis infection needs new and more efficient drugs. Reactive Nitrogen and Oxygen Species (RNOS) are key compounds used by the immune system to fight intracellular infections, particularly M. tuberculosis. In this context, we analyzed HNO potential to kill mycobacteria.We evaluated the viability and biological response of mycobacteria towards HNO releasing compounds. (Source: Tuberculosis)
Source: Tuberculosis - February 2, 2018 Category: Respiratory Medicine Authors: Jordana Galizia, Mariano Prado Acosta, Estefan ía Urdániz, Marcelo A. Martí, Mariana Piuri Source Type: research
Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice
The role, if any, played by the kinin system in tuberculosis infection models, either in vivo or in vitro, was investigated. The effects of Mycobacterium tuberculosis infection on C57BL/6 wild type, B1R −/−, B2R−/− and double B1R/B2R knockout mice were evaluated. Immunohistochemistry analysis was carried out to assess B1R and B2R expression in spleens and lungs of M. tuberculosis-infected mice. In addition, in vitro experiments with M. tuberculosis-infected macrophages were performed. The i n vivo effects of HOE-140 and SSR240612 on the mice model of infection were also evaluated. (Source: Tuberculosis)
Source: Tuberculosis - January 19, 2018 Category: Respiratory Medicine Authors: Valn ês S. Rodrigues-Junior, Priscilla B. Pail, Anne D. Villela, Virgínia C.A. Falcão, Adílio S. Dadda, Bruno L. Abbadi, João B. Pesquero, Diógenes S. Santos, Luiz A. Basso, Maria M. Campos Tags: Drug Discovery and Resistance Source Type: research
Existing blood transcriptional classifiers accurately discriminate active tuberculosis from latent infection in individuals from south India
Several studies have identified blood transcriptomic signatures that can distinguish active from latent Tuberculosis (TB). The purpose of this study was to assess how well these existing gene profiles classify TB disease in a South Indian population. RNA sequencing was performed on whole blood PAXgene samples collected from 28 TB patients and 16 latently TB infected (LTBI) subjects enrolled as part of an ongoing household contact study. Differential gene expression and clustering analyses were performed and compared with explicit predictive testing of TB and LTBI individuals based on established gene signatures. (Source: Tuberculosis)
Source: Tuberculosis - January 19, 2018 Category: Respiratory Medicine Authors: Samantha Leong, Yue Zhao, Noyal M. Joseph, Natasha S. Hochberg, Sonali Sarkar, Jane Pleskunas, David Hom, Subitha Lakshminarayanan, C. Robert Horsburgh, Gautam Roy, Jerrold J. Ellner, W. Evan Johnson, Padmini Salgame Tags: Diagnostics Source Type: research
