Combinatory activity of linezolid and levofloxacin with antituberculosis drugs in Mycobacterium tuberculosis
The increase of multidrug and extensively resistant Mycobacterium tuberculosis strains turns the search for new tuberculosis (TB) treatment options of paramount importance. (Source: Tuberculosis)
Source: Tuberculosis - May 14, 2018 Category: Respiratory Medicine Authors: Nathally Claudiane de Souza Santos, Regiane Bertin de Lima Scodro, Aryadne Larissa de Almeida, Vanessa Pietrowski Baldin, Sandra Sayuri Nakamura de Vasconcelos, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Paula Aline Zanetti Campanerut- Source Type: research
In vitro combinatory activity of piperine and anti-tuberculosis drugs in mycobacterium tuberculosis
Tuberculosis (TB) is an important public health problem worldwide and the emergence of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB worsened the global context. The resistance in Mycobacterium tuberculosis, the causative agent of TB, can partially derive from efflux pumps (EPs) activity in plasma membrane. Due to the recent discovery of piperine (PIP), an organic alkaloid compound, increasing the bioavailability of various drugs, the current assay evaluated the combined activity of PIP and anti-TB drugs in susceptible and resistant M. (Source: Tuberculosis)
Source: Tuberculosis - May 14, 2018 Category: Respiratory Medicine Authors: La íse Adriane Hegeto, Katiany R. Caleffi-Ferracioli, Sandra S. Nakamura-Vasconcelos, Aryadne Larissa de Almeida, Vanessa Pietrowski Baldin, Celso Vataru Nakamura, Vera Lúcia D. Siqueira, Regiane B.L. Scodro, Rosilene Fressatti Cardoso Source Type: research
Utility of pyrosequencing for rapid detection of tubercular meningitis (TBM) and associated susceptibility directly from CSF specimens
Tubercular meningitis (TBM) is a serious form of tuberculosis (TB). The diagnosis of TBM& susceptibility/resistance is difficult as TB MGIT culture lacks sensitivity& timeliness. Timely and accurate diagnosis of the TBM is the need of the hour for initiation of appropriate therapy. We have exploited pyrosequencing to detect TB and Multi/extensively drug resistant TB (MDR/ XDR-TB) directly from Cerebrospinal Fluid (CSF). (Source: Tuberculosis)
Source: Tuberculosis - May 14, 2018 Category: Respiratory Medicine Authors: Kanchan Ajbani, Mubin Kazi, Swapna Naik, Rajeev Soman, Anjali Shetty, Camilla Rodrigues Source Type: research
LpqT improves mycobacteria survival in macrophages by inhibiting TLR2 mediated inflammatory cytokine expression and cell apoptosis
Tuberculosis is a severe infectious disease caused by Mycobacterium tuberculosis (Mtb). LpqT is a lipoprotein of Mtb identified as a candidate virulence factor by a high-throughput screen searching for genes important for mycobacteria intracellular survival. To investigate its function, we constructed M. smegmatis strains deficient of LpqT or overexpressing LpqT. Wildtype or LpqT modified M. smegmatis strains were used to infect macrophages and mice, and intracellular survival of mycobacteria was measured. (Source: Tuberculosis)
Source: Tuberculosis - May 14, 2018 Category: Respiratory Medicine Authors: Fengge Li, Lili Feng, Chunyan Jin, Xiaoyu Wu, Lingbo Fan, Sidong Xiong, Yuanshu Dong Tags: Mechanisms of Pathogenesis Source Type: research
IP-10 and RANTES as biomarkers for pulmonary tuberculosis diagnosis and monitoring
We aimed to determine whether IP-10 and RANTES plasma levels can be used in diagnosis and monitoring of pulmonary tuberculosis (PTB). (Source: Tuberculosis)
Source: Tuberculosis - May 12, 2018 Category: Respiratory Medicine Authors: Yanfeng Zhao, Xiqin Yang, Xuhui Zhang, Qin Yu, Ping Zhao, Jianxia Wang, Cuimi Duan, Jiangxue Li, Heather Johnson, Xiaoyan Feng, Heqiu Zhang Source Type: research
Elucidating the antimicrobial mechanisms of colistin sulfate on Mycobacterium tuberculosis using metabolomics
Considering the disadvantageous of first line anti-tuberculosis (TB) drugs, including poor patient adherence, drug side effects, the long treatment duration and rapidly increasing microbe resistance, alternative treatment strategies are needed. Colistin sulfate (CS), a polymyxin antibiotic considered a last-resort antibiotics for treating multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter, has antimicrobial activity towards mycobacteria, and could serve as a possible anti-TB drug. (Source: Tuberculosis)
Source: Tuberculosis - May 8, 2018 Category: Respiratory Medicine Authors: Nadia Koen, S. van Breda, Du Toit Loots Source Type: research
Platelet-monocyte interaction in Mycobacterium tuberculosis infection
The immune effects of platelets and platelet-leukocyte aggregation are increasingly recognized. We studied the occurrence of platelet-monocyte aggregation (PMA) in patients with pulmonary tuberculosis (TB), the processes underlying PMA and consequences for cytokine responses.In a cross-sectional study involving 65 Tanzanian TB patients in different phases of treatment and 29 healthy controls, TB patients had a significantly higher PMA. This increased PMA in TB patients was associated with increased monocyte CCR5, CD16 expression and PF4, but not with increased membrane-expressed or soluble P-selectin expression. (Source: Tuberculosis)
Source: Tuberculosis - May 8, 2018 Category: Respiratory Medicine Authors: Vesla Kullaya, Andre van der Ven, Stellah Mpagama, Blandina T. Mmbaga, Philip de Groot, Gibson Kibiki, Quirijn de Mast Source Type: research
Characterization of mutations conferring streptomycin resistance to multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar
Numerous studies report that mutations of rpsL (encoding the S12 protein), rrs (encoding 16S rRNA) and gidB (encoding rRNA methyltransferase) are responsible for conferring resistance to streptomycin (STR), which is usually used in both multidrug-resistant tuberculosis (MDR-TB) treatments and re-treatments in Myanmar. The aim of this study was to explore the variation and frequency of mutations in rpsL, rrs and gidB in 141 STR-resistant MDR-TB isolates from Myanmar. Most isolates belonged to the Beijing genotype (105, 74.5%). (Source: Tuberculosis)
Source: Tuberculosis - May 7, 2018 Category: Respiratory Medicine Authors: Nan Aye Thida Oo, Lai Lai San, Jeewan Thapa, Khin Saw Aye, Wah Wah Aung, Chie Nakajima, Yasuhiko Suzuki Source Type: research
Endothelial lineage-specific interaction of Mycobacterium tuberculosis with the blood and lymphatic systems
Mycobacterium tuberculosis (Mtb) has plagued humanity for tens of thousands of years, yet still remains a threat to human health. Its pathology is largely associated with pulmonary tuberculosis with symptoms including fever, hemoptysis, and chest pain. Mtb, however, also manifests in other extrapulmonary organs, such as the pleura, bones, gastrointestinal tract, central nervous system, and lymph nodes. Compared to the knowledge of pulmonary tuberculosis, extrapulmonary pathologies of Mtb are quite understudied. (Source: Tuberculosis)
Source: Tuberculosis - May 4, 2018 Category: Respiratory Medicine Authors: Paul M. Kim, Jae-Jin Lee, Dongwon Choi, Hyungjin Eoh, Young-Kwon Hong Tags: Review Source Type: research
Delamanid: From discovery to its use for pulmonary multidrug-resistant tuberculosis (MDR-TB)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is the leading cause of death from an infectious disease globally. The wide-spread and ever-increasing resistance to TB drugs is reducing the effectiveness of treatment and jeopardizing TB control. New effective drugs with acceptable safety profiles are needed to turn the tide. Since the early 1990s, Otsuka Pharmaceutical Co., Ltd. has had a TB drug development program that resulted in the selection and development of delamanid (OPC-67683, Deltyba ®), a first-in-class bicyclic nitroimidazole. (Source: Tuberculosis)
Source: Tuberculosis - May 3, 2018 Category: Respiratory Medicine Authors: Yongge Liu, Makoto Matsumoto, Hidekaza Ishida, Kinue Ohguro, Masuhiro Yoshitake, Rajesh Gupta, Lawrence Geiter, Jeffrey Hafkin Tags: Review Source Type: research
Editorial Board
(Source: Tuberculosis)
Source: Tuberculosis - May 1, 2018 Category: Respiratory Medicine Source Type: research
Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia
Genome-wide analysis of 517 Mycobacterium tuberculosis isolates from New South Wales, Australia, have identified previously reported and 8 new mutations in Rv0678 and atpE genes linked to in vitro resistance to bedaquiline, a new class of antimycobacterial drugs. These mutations were present in 2.9% of prospectively sequenced genomes but in 10.6% of strains that were phenotypically multidrug-resistant. However only 14% of isolates with these mutations demonstrated elevated minimum inhibitory concentrations to bedaquiline. (Source: Tuberculosis)
Source: Tuberculosis - April 25, 2018 Category: Respiratory Medicine Authors: Elena Martinez, Daneeta Hennessy, Peter Jelfs, Taryn Crighton, Sharon C-A. Chen, Vitali Sintchenko Source Type: research
Corrigendum to “A whole genome bioinformatic approach to determine potential latent phase specific targets in Mycobacterium tuberculosis” [Tuberculosis 97 (March 2016) 181–192]
The authors regret that the below text was missed in the acknowledgements section. (Source: Tuberculosis)
Source: Tuberculosis - April 25, 2018 Category: Respiratory Medicine Authors: Lucas A. Defelipe, Dario Fernandez Do Porto, Pablo Ivan Pereira Ramos, Marisa Fabiana Nicolas, Ezequiel Sosa, Leandro Radusky, Esteban Lanzarotti, Adrian G. Turjanski, Marcelo A. Marti Tags: Corrigendum Source Type: research
Prolonged intervals during Mycobacterium tuberculosis subunit vaccine boosting contributes to eliciting immunity mediated by central memory-like T cells
In this study, mice were immunized with fusion protein ESAT6-Ag85B-MPT64 (190 –198)-Mtb8.4-Rv2626c (LT70) based subunit vaccine three times according to the following schedules: ① 0, 3rd and 6th week respectively (0-3-6w), ② 0, 4th and 12th week (0-4-12w), and ③ 0, 4th and 24th week (0-4-24w). (Source: Tuberculosis)
Source: Tuberculosis - April 23, 2018 Category: Respiratory Medicine Authors: Chunxiang Bai, Juanjuan He, Hongxia Niu, Lina Hu, Yanping Luo, Xun Liu, Liang Peng, Bingdong Zhu Tags: Immunological Aspects Source Type: research
