Utility of pyrosequencing for rapid detection of tubercular meningitis (TBM) and associated susceptibility directly from CSF specimens

Tubercular meningitis (TBM) is a serious form of tuberculosis (TB). The diagnosis of TBM& susceptibility/resistance is difficult as TB MGIT culture lacks sensitivity& timeliness. Timely and accurate diagnosis of the TBM is the need of the hour for initiation of appropriate therapy. We have exploited pyrosequencing to detect TB and Multi/extensively drug resistant TB (MDR/ XDR-TB) directly from Cerebrospinal Fluid (CSF).

Source: Tuberculosis - May 14, 2018 Category: Respiratory Medicine Authors: Kanchan Ajbani, Mubin Kazi, Swapna Naik, Rajeev Soman, Anjali Shetty, Camilla Rodrigues Source Type: research