In vitro combinatory activity of piperine and anti-tuberculosis drugs in mycobacterium tuberculosis

Tuberculosis (TB) is an important public health problem worldwide and the emergence of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB worsened the global context. The resistance in Mycobacterium tuberculosis, the causative agent of TB, can partially derive from efflux pumps (EPs) activity in plasma membrane. Due to the recent discovery of piperine (PIP), an organic alkaloid compound, increasing the bioavailability of various drugs, the current assay evaluated the combined activity of PIP and anti-TB drugs in susceptible and resistant M.

Source: Tuberculosis - May 14, 2018 Category: Respiratory Medicine Authors: La íse Adriane Hegeto, Katiany R. Caleffi-Ferracioli, Sandra S. Nakamura-Vasconcelos, Aryadne Larissa de Almeida, Vanessa Pietrowski Baldin, Celso Vataru Nakamura, Vera Lúcia D. Siqueira, Regiane B.L. Scodro, Rosilene Fressatti Cardoso Source Type: research