Evaluation of nitroxyl donors' effect on mycobacteria

Nitroxyl (HNO) is a highly elusive and reactive molecule. Nitroxyl biological effects and pharmacological potential are becoming increasingly relevant. M. tuberculosis infection needs new and more efficient drugs. Reactive Nitrogen and Oxygen Species (RNOS) are key compounds used by the immune system to fight intracellular infections, particularly M. tuberculosis. In this context, we analyzed HNO potential to kill mycobacteria.We evaluated the viability and biological response of mycobacteria towards HNO releasing compounds.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Source Type: research