Evaluation of a synthetic peptide for the detection of anti-Mycobacterium tuberculosis curli pili IgG antibodies in patients with pulmonary tuberculosis

Tuberculosis (TB) remains a serious threat in underdeveloped areas. Mycobacterium tuberculosis curli pili (MTP), a virulence factor, is a potential biomarker for a reliable point of care (POC) test and was evaluated for its ability to react with Immunoglobulin G (IgG) in TB patients. An MTP synthetic peptide in a slot blot assay was used to screen serum/plasma samples (n  = 65) in 3 separate cohorts, including 40 TB positive (16 HIV co-infected), 20 TB negative/HIV negative patients and 5 healthy volunteers.

Source: Tuberculosis - February 3, 2018 Category: Respiratory Medicine Authors: Natasha Naidoo, Balakrishna Pillay, Martin Bubb, Alexander Pym, Thamsanqa Chiliza, Kogieleum Naidoo, Thumbi Ndung'u, Victoria O. Kasprowicz, Manormoney Pillay Source Type: research