Inhibiting HLA-G restores IFN- γ and TNF-α producing T cell in pleural Tuberculosis

Human Leukocyte Antigen-G (HLA-G), a non-classical, class Ib molecule, has been shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity and differentiation by modulating cytokine secretion. Due to its immune-suppressive function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it favours immune evasion of microbes and tumors by inhibiting immune and inflammatory responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G and its receptor Ig-like transcript −2 (ILT-2) in disseminated vs.

Source: Tuberculosis - February 6, 2018 Category: Respiratory Medicine Authors: Abhinav Saurabh, Sushmita Chakraborty, Prabin Kumar, Anant Mohan, Anuj K. Bhatnagar, Narayan Rishi, Dipendra Kumar Mitra Tags: Immunological Aspects Source Type: research