Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival

Cholesterol, an essential cellular component in macrophages, is exploited for entry and long-term survival of Mycobacterium inside the host. Cholesterol-deficient macrophages can restrict the cholesterol-dependent entry of Mycobacterium. Rv3499c protein in Mycobacterium has high binding affinity for cholesterol. Rv3499c gene is a part of mce4 operon which is reported to act as cholesterol transport system in mycobacteria. Earlier we reported Rv3499c protein to localise on cell wall and facilitate entry of Mycobacterium inside macrophages.

Source: Tuberculosis - February 3, 2018 Category: Respiratory Medicine Authors: Rajesh Sinha, Pooja Singh, Neeraj k Saini, Ajit Kumar, Rakesh Pathak, Amita Chandolia, Kushal Garima, Gaurav Tyagi, Madhu Chopra, Ashok Kumar Prasad, Hanumantharao G. Raj, Mridula Bose Source Type: research