Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice

The role, if any, played by the kinin system in tuberculosis infection models, either in vivo or in vitro, was investigated. The effects of Mycobacterium tuberculosis infection on C57BL/6 wild type, B1R −/−, B2R−/− and double B1R/B2R knockout mice were evaluated. Immunohistochemistry analysis was carried out to assess B1R and B2R expression in spleens and lungs of M. tuberculosis-infected mice. In addition, in vitro experiments with M. tuberculosis-infected macrophages were performed. The i n vivo effects of HOE-140 and SSR240612 on the mice model of infection were also evaluated.

Source: Tuberculosis - January 19, 2018 Category: Respiratory Medicine Authors: Valn ês S. Rodrigues-Junior, Priscilla B. Pail, Anne D. Villela, Virgínia C.A. Falcão, Adílio S. Dadda, Bruno L. Abbadi, João B. Pesquero, Diógenes S. Santos, Luiz A. Basso, Maria M. Campos Tags: Drug Discovery and Resistance Source Type: research