Four new HLA class I alleles, HLA ‐A*02:681, HLA‐A*30:111, HLA‐A*68:164 and HLA‐B*35:01:46
Four new HLA class I alleles,
HLA‐A*02:681, HLA‐A*30:111, HLA‐A*68:164 and HLA‐B*35:01:46 were described in Spaniards. (Source: Tissue Antigens)
Source: Tissue Antigens - June 15, 2017 Category: Allergy & Immunology Authors: F. S ánchez‐Gordo, A. Balas, J. M. Gomez‐Zumaquero, J. L. Vicario Tags: NEW ALLELE ALERTS Source Type: research
Strain ‐based HLA association analysis identified HLA‐DRB1*09:01 associated with modern strain tuberculosis
This study investigated the possible association of HLA class II genes with TB caused by modern and ancient Mycobacterium tuberculosis (MTB). The study included 682 patients with TB and 836 control subjects who were typed for
HLA‐DRB1
and
HLA‐DQB1
alleles. MTB strains were classified using a large sequence polymorphism typing method. Association analysis was performed using common HLA alleles and haplotypes in different MTB strains. HLA association analysis of patients infected with modern MTB strains showed significant association for
HLA‐DRB1*09:01 (odds ratio [OR] = 1.82; P‐value = 9.88 × 10−...
Source: Tissue Antigens - June 14, 2017 Category: Allergy & Immunology Authors: L. Toyo ‐oka, S. Mahasirimongkol, H. Yanai, T. Mushiroda, S. Wattanapokayakit, N. Wichukchinda, N. Yamada, N. Smittipat, T. Juthayothin, P. Palittapongarnpim, S. Nedsuwan, P. Kantipong, A. Takahashi, M. Kubo, P. Sawanpanyalert, K. Tokunaga Tags: ORIGINAL ARTICLE Source Type: research
The new HLA ‐B*50:51 allele was generated by intralocus recombination between B*50:01:01:02 and B*14:02:01
The new B*50:51 allele was found in 3 Caucasians from Southern Spain. (Source: Tissue Antigens)
Source: Tissue Antigens - June 13, 2017 Category: Allergy & Immunology Authors: F. S ánchez‐Gordo, J. M. Gomez‐Zumaquero, J. L. Vicario, A. Balas Tags: NEW ALLELE ALERTS Source Type: research
Nomenclature for factors of the HLA system, update March 2017
(Source: Tissue Antigens)
Source: Tissue Antigens - June 9, 2017 Category: Allergy & Immunology Authors: S. G. E. Marsh, Tags: NOMENCLATURE UPDATE Source Type: research
Nomenclature for factors of the HLA system, update February 2017
(Source: Tissue Antigens)
Source: Tissue Antigens - June 9, 2017 Category: Allergy & Immunology Authors: S. G. E. Marsh, Tags: NOMENCLATURE UPDATE Source Type: research
Nomenclature for factors of the HLA system, update January 2017
(Source: Tissue Antigens)
Source: Tissue Antigens - June 9, 2017 Category: Allergy & Immunology Authors: S. G. E. Marsh, Tags: NOMENCLATURE UPDATE Source Type: research
Publication ethos in the immunogenetics community
(Source: Tissue Antigens)
Source: Tissue Antigens - June 9, 2017 Category: Allergy & Immunology Authors: S. G. E. Marsh, A. B. Hahn, D. Middleton Tags: EDITORIAL Source Type: research
Issue Information
(Source: Tissue Antigens)
Source: Tissue Antigens - June 9, 2017 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research
Sequence ‐based typing identification of a novel HLA‐C allele, C*12:214, in a Han Chinese individual
One nucleotide substitution at position 497 of HLA‐C*12:02:01 results in a novel allele, HLA‐C*12:214. (Source: Tissue Antigens)
Source: Tissue Antigens - June 6, 2017 Category: Allergy & Immunology Authors: H. J. Yang, X. D. Mo, J. B. Fang, X. Q. Yang, T. Zhang Tags: NEW ALLELE ALERTS Source Type: research
Effects of weak/non ‐complement‐binding HLA antibodies on C1q‐binding
In conclusion, if targeting the same epitope, an excess of IgG2/4 is repressing the extent of IgG1/3 triggered C1q‐binding in vitro. Such IgG subclass constellations are present in about a third of sensitized patients and their net effect on C1q‐binding is slightly inhibitory. (Source: Tissue Antigens)
Source: Tissue Antigens - June 5, 2017 Category: Allergy & Immunology Authors: G. H önger, P. Amico, M.‐L. Arnold, B. M. Spriewald, S. Schaub Tags: ORIGINAL ARTICLE Source Type: research
HLA ‐DRB3*02:61Q
, a novel HLA‐DRB3 allele identified in a volunteer bone marrow donor
HLA‐DRB3*02:61Q
, a novel HLA‐DRB3 allele identified in a volunteer bone marrow donor. (Source: Tissue Antigens)
Source: Tissue Antigens - June 1, 2017 Category: Allergy & Immunology Authors: S. Ulrich, E. Matzhold, U. Posch, P. Schlenke, W. Helmberg Tags: NEW ALLELE ALERTS Source Type: research
Different
DRB1*03:01 ‐DQB1*02:01 haplotypes confer different risk for celiac disease
This study extends previous analyses on different HLA haplotypes in celiac disease using next generation targeted sequencing.
Included were 143 patients with celiac disease and 135 non‐celiac disease controls investigated at median 9.8 years (1.4‐18.3 years). PCR‐based amplification of HLA and sequencing with Illumina MiSeq technology were used for extended sequencing of the HLA class II haplotypes HLA‐DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1, respectively. Odds ratios were computed marginally for every allele and haplotype as the ratio of allelic frequency in patients and controls as ratio of exposure rates (RR),...
Source: Tissue Antigens - June 1, 2017 Category: Allergy & Immunology Authors: S. Alshiekh, L. P. Zhao, Å. Lernmark, D. E. Geraghty, Å. T. Naluai, D. Agardh Tags: ORIGINAL ARTICLE Source Type: research
A novel HLA ‐G allele, HLA‐G*01:01:01:07, was identified in a Chinese patient with Posner‐Schlossman syndrome
A novel HLA‐G allele, HLA‐G*01:01:01:07, was identified in a Chinese patient with Posner‐Schlossman syndrome. (Source: Tissue Antigens)
Source: Tissue Antigens - May 30, 2017 Category: Allergy & Immunology Authors: J. Zhao, X. ‐S. Huang, S.‐M. Peng, S.‐Y. Mei, Y.‐P. Xu Tags: NEW ALLELE ALERTS Source Type: research
Identification of a novel HLA ‐C*08 allele, HLA‐C*08:01:20
HLA‐C*08:01:20 differs from C*08:01:01 by a single nucleotide substitution at position 93 of exon 2. (Source: Tissue Antigens)
Source: Tissue Antigens - May 29, 2017 Category: Allergy & Immunology Authors: M. ‐R. Huo, B. Xi, Y. Yu, D. Li Tags: NEW ALLELE ALERTS Source Type: research
Polymorphism at residue 156 of the new HLA ‐A*02:683 allele suggests immunological relevance
HLA‐A*02:683 is most similar to 4 different HLA‐A*02 subtypes with a single nucleotide difference. (Source: Tissue Antigens)
Source: Tissue Antigens - May 28, 2017 Category: Allergy & Immunology Authors: B. Duygu, B. M. Matern, M. Groeneweg, C. E. M. Voorter, M. G. J. Tilanus Tags: NEW ALLELE ALERTS Source Type: research
