Characterization of the novel HLA ‐B*48:43 allele by sequencing‐based typing
HLA‐B*48:43 differs from HLA‐B*48:01:01:01 by two nucleotide substitutions at positions 981 and 986. (Source: Tissue Antigens)
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Authors: L. ‐Q. Zhang, X.‐Y. Zhou, Y. Xiao, X.‐Q. Yang, J.‐P. Cai Tags: NEW ALLELE ALERTS Source Type: research
Characterisation of the novel HLA ‐G null allele, HLA‐G*01:21N, in Finnish individuals
Summary
We identified the novel HLA‐G*01:21N null allele in Finnish Caucasian individuals. (Source: Tissue Antigens)
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Authors: M. ‐C. Faucher, K. Louvanto, S. Syrjänen, M. Roger Tags: NEW ALLELE ALERTS Source Type: research
Detection of a novel HLA ‐DRB1*12 variant, HLA‐DRB1*12:68, in a Taiwanese individual
One nucleotide substitution at residue 628 of HLA‐DRB1*12:01:01:01 results in a novel allele, HLA‐DRB1*12:68. (Source: Tissue Antigens)
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Authors: K. L. Yang, L. Y. Lin, P. Y. Lin Tags: NEW ALLELE ALERTS Source Type: research
Identification of the novel HLA ‐B*57:91 allele, by next‐generation sequencing in a Spanish individual
HLA‐B*57:91 differs from HLA‐B*57:01:01 by a single nucleotide substitution resulting in an amino acid change. (Source: Tissue Antigens)
Source: Tissue Antigens - November 13, 2017 Category: Allergy & Immunology Authors: E. Enrich, E. Campos, J. L. Caro ‐Oleas, M. J. Herrero‐Mata, F. Rudilla Tags: NEW ALLELE ALERTS Source Type: research
Three new HLA class I alleles with synonymous mutations: HLA ‐A*03:01:62, ‐C*07:02:82 and ‐C*12:03:42
Three new HLA class I alleles with synonymous mutations were identified. (Source: Tissue Antigens)
Source: Tissue Antigens - November 10, 2017 Category: Allergy & Immunology Authors: M. R. Moya ‐Quiles, A. Balas, M. Muro, A. M. García‐Alonso, J. L. Vicario Tags: NEW ALLELE ALERTS Source Type: research
Beyond disease susceptibility – leveraging GWAS for new insights into complex disease biology
Genetic studies in complex diseases have been highly successful, but have also been largely one‐dimensional: predominantly focusing on the genetic contribution to disease susceptibility. While this is undoubtedly important – indeed it is a pre‐requisite for understanding the mechanisms underlying disease development – there are many other important aspects of disease biology that have received comparatively little attention. In this review, I will discuss how existing genetic data can be leveraged to provide new insights into other aspects of disease biology, why such insights could change the way we think about co...
Source: Tissue Antigens - November 6, 2017 Category: Allergy & Immunology Authors: J. C. Lee Tags: REVIEW ARTICLE Source Type: research
HLA ‐DQB1*02:102, a novel allele identified by Next Generation Sequencing in a Spanish individual
Summary
HLA‐DQB1*02:102 differs from DQB1*02:01:01 by a single nucleotide substitution resulting in an amino acid change. (Source: Tissue Antigens)
Source: Tissue Antigens - November 1, 2017 Category: Allergy & Immunology Authors: E. Enrich, L. Mongay, J. L. Caro ‐Oleas, M. J. Herrero‐Mata, F. Rudilla Tags: NEW ALLELE ALERTS Source Type: research
HLA Class II Polymorphism in Saudi Patients with Multiple Sclerosis
This study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. We found that several HLA‐DRB1 and DQB1 alleles were associated with MS. These alleles included HLA‐DRB1*15:01 (OR 3.01, 95% CI = 1.68‐5.54, p=0.0001), HLA‐DQB1*02:01 (OR 1.76, 95% CI 1.20‐2.58, p=0.0022), HLA‐DQB1*06:02 (OR 3.52, 95% CI = 1.87‐6.86, P < 0.0001), and HLA‐DQB1*06:03 (OR = 2.42, 95% CI = 1.16‐5.25, P = 0.01). Interestingly, HLA‐DRB1*15:01 was associated with increased risk of previous relapses. In addition, HLA‐DRB1*15:01 and HLA‐DQB1*06:02 were found to be associated with lower vitamin D levels. This ...
Source: Tissue Antigens - November 1, 2017 Category: Allergy & Immunology Authors: M. Al Jumah, S. Kojan, A. M. Al Shehri, M. Al Balwi, I. Al Abdulkarim, E. M. Masuadi, Y. Alhaidan, A. Alabdulrahman, H. M. Fakhoury, A. H. Hajeer Tags: ORIGINAL ARTICLE Source Type: research
The killer cell lectin like receptor B1 (KLRB1) 503T > C polymorphism (rs1135816) and acute rejection after liver transplantation
The KLRB1 gene encodes for CD161 expressed by different subsets of leukocytes involved in the development of acute liver transplant rejection. The single nucleotide polymorphism (SNP) 503T>C (rs1135816) in the KLRB1 gene represents a missense mutation modifying functional properties of CD161. The aim of our study is to determine whether the SNP 503T>C is associated with acute liver transplant rejection. We genotyped the SNP for 163 liver recipients without acute rejection, 125 recipients with a single acute rejection, and 53 recipients with multiple acute rejections. The genotype frequencies within the groups did not...
Source: Tissue Antigens - November 1, 2017 Category: Allergy & Immunology Authors: H. Thude, S. Rother, M. Sterneck, J. Klempnauer, B. Nashan, R. Schwinzer, M. Koch Tags: BRIEF COMMUNICATION Source Type: research
Genetic Association of HLA ‐DRB1 Multiple Polymorphisms with Dermatomyositis in Chinese Population
Genetic variation in human leukocyte antigen (HLA) plays an important role in the pathogenesis of dermatomyositis (DM). The aim of this study was to investigate the association of HLA class II with DM in China. 224 DM patients and 300 healthy controls were randomly enrolled at China‐Japan Friendship Hospital. High resolution typing of HLA‐DRB1 alleles was performed by sequencing based typing (SBT). The HLA‐DQA1 and HLA‐DQB1 alleles were determined by PCR sequence‐specific primers (SSP). The frequencies of HLA‐DRB1*09:01 (28.6% vs. 11.3%, P< 0.0001, OR = 3.14,95% CI = 2.47‐3.99) and HLA‐DRB1*12:01 (29.0% ...
Source: Tissue Antigens - November 1, 2017 Category: Allergy & Immunology Authors: Lin Jinming, Zhang Yongbiao, Qinglin Peng, Hanbo Yang, Jingli Shi, Mingliang Gu, Wenming Zhao, Guochun Wang Tags: ORIGINAL ARTICLE Source Type: research
A novel HLA class II allele, HLA ‐DRB1*04:01:17, identified in a Chinese volunteer donor for China Marrow Donor Program
One nucleotide replacement at nucleotide 144 of HLA‐DRB1*04:01:01 results in a new allele, HLA‐DRB1*04:01:17. (Source: Tissue Antigens)
Source: Tissue Antigens - October 29, 2017 Category: Allergy & Immunology Authors: Z. ‐H. Feng, Z.‐X. Yang, W.‐H. Ma, S.‐T. Pang Tags: NEW ALLELE ALERTS Source Type: research
A novel HLA ‐DRB1*07 allele, HLA‐DRB1*07:01:22, identified in a Chinese individual
Abstract
HLA‐DRB1*07:01:22 differs from HLA‐DRB1*07:01:01:01 at position 244 (C > T) in exon 2. (Source: Tissue Antigens)
Source: Tissue Antigens - October 27, 2017 Category: Allergy & Immunology Authors: Xiao ‐Yang Zhou, Li‐Qun Zhang, Yao Xiao, Xiao‐Qin Yang, Jian‐Ping Cai Tags: NEW ALLELE ALERTS Source Type: research
Sequence ‐based typing identification of the novel HLA‐C*07:565 variant in a Chinese family
Abstract
HLA‐C*07:565 differs from HLA‐C*07:02:01:01 (400C‐ > T, exon 3, L110F). (Source: Tissue Antigens)
Source: Tissue Antigens - October 24, 2017 Category: Allergy & Immunology Authors: Jiying Wang, Yan Zhang, Qinghua Li, Kun Ru, Xiaojing Wang Tags: NEW ALLELE ALERTS Source Type: research
Three New HLA Class I Alleles with Synonymous Mutations: HLA ‐A*03:01:62, −C*07:02:82 and ‐C*12:03:42
ABSTRACT
Three new HLA class I alleles with synonymous mutations were identified. (Source: Tissue Antigens)
Source: Tissue Antigens - October 24, 2017 Category: Allergy & Immunology Authors: Mar ía Rosa Moya‐Quiles, Antonio Balas, Manuel Muro, Ana María García‐Alonso, Jose L. Vicario Tags: NEW ALLELE ALERTS Source Type: research
The novel allele, HLA ‐A*24:383, was identified in a Chinese individual by sequence‐based typing
Summary
HLA‐A*24:383 differs HLA‐A*24:02:01:01 by one nucleotide substitution from C to G in exon 4, position 755. (Source: Tissue Antigens)
Source: Tissue Antigens - October 24, 2017 Category: Allergy & Immunology Authors: Bin Hu, Zhixia Yang, Haiping Pan, Shutao Pang Tags: NEW ALLELE ALERTS Source Type: research
