Hematopoietic stem cell transplantation and cellular therapy
Allogeneic stem cell transplantation is a form of immunotherapy that has increased the chances of survival for patients with relapsed leukemia and high risk leukemia in remission. The major obstacles are graft‐vs‐host disease (GVHD) involving vital organs and infections. A most efficacious prophylaxis of GVHD is by depleting of T cells from the graft. However, problems of T‐depleted transplants are rejection, slow recovery of the immune system and high incidence of relapse of leukemia and myeloma. The major problem of allogeneic transplantation is the separation of a graft‐vs‐leukemia (GVL) effect from GVHD. This...
Source: Tissue Antigens - April 2, 2017 Category: Allergy & Immunology Authors: H. ‐J. Kolb Tags: REVIEW ARTICLE Source Type: research
Issue Information
(Source: Tissue Antigens)
Source: Tissue Antigens - April 2, 2017 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research
Identification of the novel
HLA ‐B*40:01:41 allele by polymerase chain reaction sequence‐based typing in a Chinese cord blood donor
HLA‐B*40:01:41 differs from
HLA‐B*40:01:01 by a single nucleotide substitution at position 195 G>A. (Source: Tissue Antigens)
Source: Tissue Antigens - March 31, 2017 Category: Allergy & Immunology Authors: N. ‐Y. Chen, W. Wang, L.‐N. Dong, J. He, F.‐M. Zhu Tags: NEW ALLELE ALERTS Source Type: research
Confirmed the full ‐length sequence of HLA‐B*44:03:02 by cloning and sequencing
Confirmed the full‐length sequence of HLA‐B*44:03:02 by cloning and sequencing in a Chinese donor. (Source: Tissue Antigens)
Source: Tissue Antigens - March 30, 2017 Category: Allergy & Immunology Authors: Z. Li, H. ‐Y. Zou Tags: NEW ALLELE ALERTS Source Type: research
The novel KIR3DS1*084 allele identified in a southern Chinese Han individual
KIR3DS1*084 allele differs from the closest allele
KIR3DS1*01301 at nucleotide 308 C>T in exon 3. (Source: Tissue Antigens)
Source: Tissue Antigens - March 30, 2017 Category: Allergy & Immunology Authors: Z. Li, S. ‐X. Wang, S.‐Q. Gao, Y.‐P. Xu Tags: NEW ALLELE ALERTS Source Type: research
Characterization of the novel
HLA ‐B*49:39 allele identified in a German leukaemia patient
HLA‐B*49:39 allele is characterised by 1 amino acid substitution in the alpha 1 domain. (Source: Tissue Antigens)
Source: Tissue Antigens - March 30, 2017 Category: Allergy & Immunology Authors: P. S. A. Becker, S. Lindner, S. ‐Z. Kim‐Wanner, G. Bug, C. Seidl Tags: NEW ALLELE ALERTS Source Type: research
Description of the novel HLA ‐A allele,
HLA‐A*11:229, identified by sequence‐based typing in a Chinese individual
HLA‐A*11:229 differs from
HLA‐A*11:01:01:01 by 1 nucleotide exchange at position 556 (G > A) with an amino exchange. (Source: Tissue Antigens)
Source: Tissue Antigens - March 27, 2017 Category: Allergy & Immunology Authors: W. ‐X. Li, L. Chen, Y. Yang, Y. Ma, G. Shen Tags: NEW ALLELE ALERTS Source Type: research
Identification of the new HLA ‐DQA1*01:15N allele in an Italian patient
The novel allele DQA1*01:15N differs from DQA1*01:03:01:01 by 1 nucleotide substitutions in exon 2. (Source: Tissue Antigens)
Source: Tissue Antigens - March 27, 2017 Category: Allergy & Immunology Authors: M. Battarra, R. Condello, M. Testi, C. Stellitano, M. Andreani Tags: NEW ALLELE ALERTS Source Type: research
The novel KIR3DS1*085 allele identified in a southern Chinese Han individual
KIR3DS1*085 allele differs from the closest allele
KIR3DS1*01301 at nucleotide 934 C>T in exon 5. (Source: Tissue Antigens)
Source: Tissue Antigens - March 27, 2017 Category: Allergy & Immunology Authors: S. ‐X. Wang, Y.‐P. Xu, S.‐Q. Gao, A.‐L. Yang Tags: NEW ALLELE ALERTS Source Type: research
Identification of 2 novel HLA ‐B alleles, HLA‐B*55:02:09 and HLA‐B*55:80 in Chinese individuals
HLA‐B*55:02:09 and HLA‐B*55:80 differ from HLA‐B*55:02:01 by 1 single nucleotide substitution, respectively. (Source: Tissue Antigens)
Source: Tissue Antigens - March 24, 2017 Category: Allergy & Immunology Authors: S. ‐D. Tao, L.‐N. Dong, Z.‐D. Han, J. He, F.‐M. Zhu Tags: NEW ALLELE ALERTS Source Type: research
Identification of a novel allele, HLA ‐B*15:01:23, in a platelet donor by sequence‐based typing
HLA‐B*15:01:23 has 1 synonymous nucleotide change from HLA‐B*15:01:01:01 at nucleotide 393 (codon 107 glycine). (Source: Tissue Antigens)
Source: Tissue Antigens - March 20, 2017 Category: Allergy & Immunology Authors: J. ‐P. Li, X.‐F. Li, X. Zhang, F.‐Q. Lin, K.‐L. Zhang Tags: NEW ALLELE ALERTS Source Type: research
Detection of a novel HLA ‐A*30 variant, A*30:109, in a Taiwanese individual
One nucleotide substitution at residue 488 of HLA‐A*30:01:02 results in a novel allele, HLA‐A*30:109. (Source: Tissue Antigens)
Source: Tissue Antigens - March 18, 2017 Category: Allergy & Immunology Authors: K. L. Yang, P. Y. Lin Tags: NEW ALLELE ALERTS Source Type: research
Identification of a novel HLA allele,
HLA ‐B*15:416, in a bone marrow hematopoietic stem cell donor
The novel
HLA‐B*15:416 allele differs from
HLA‐B*15:01:01:01 by a single nucleotide substitution at codon 114. (Source: Tissue Antigens)
Source: Tissue Antigens - March 17, 2017 Category: Allergy & Immunology Authors: B. Proust, D. Masson, B. P. Proust, M. Baudron, F. Dehaut Tags: NEW ALLELE ALERTS Source Type: research
Full ‐length sequence of HLA‐B*55:02:01:01, confirmed by cloning and sequencing
Full‐length sequence of
HLA‐B*55:02:01:01, confirmed by cloning and sequencing in a Chinese donor. (Source: Tissue Antigens)
Source: Tissue Antigens - March 13, 2017 Category: Allergy & Immunology Authors: Z. Li, H. ‐Y. Zou Tags: NEW ALLELE ALERTS Source Type: research
Characterization of the novel HLA ‐DRB1*11:01:20 allele
The HLA‐
DRB1*11:01:20 allele differs from
DRB1*11:01:01:01 by 1 nucleotide substitution at position 219. (Source: Tissue Antigens)
Source: Tissue Antigens - March 11, 2017 Category: Allergy & Immunology Authors: J. W. Zheng, J. H. Xie, Y. Sun, Y. Q. Jiang, D. Xiang Tags: New allele alerts Source Type: research
