Identification of the novel HLA ‐B*27:04:06 allele in a Chinese bone marrow donor
Summary
HLA‐B*27:04:06 differs from HLA‐B*27:04:01 by a single nucleotide substitution at position 396 C>A. (Source: Tissue Antigens)
Source: Tissue Antigens - November 28, 2017 Category: Allergy & Immunology Authors: F Wang, Z ‐D. Han, L‐N Dong, J. He, F‐M. Zhu Tags: NEW ALLELE ALERTS Source Type: research
Quantification of classical HLA class I mRNA by allele ‐specific real‐time polymerase chain reaction for most Han individuals
This study provides a tool for detecting the comprehensive expression profile of HLA class I alleles and will be useful not only for the investigation of the molecular mechanism underlying HLA allele expression regulation but also for exploration of immunological mechanisms involving HLA expression in the fields of tumour immune evasion, viral infection, auto‐immune disorders and GVHD after HSCT. (Source: Tissue Antigens)
Source: Tissue Antigens - November 25, 2017 Category: Allergy & Immunology Authors: N. Pan, S. Lu, W. Wang, F. Miao, H. Sun, S. Wu, D. Nan, J. Qiu, J. Xu, J. Zhang Tags: ORIGINAL ARTICLE Source Type: research
Detection and clinical impact of human leukocyte antigen antibodies in lung transplantation: A systematic review and meta ‐analysis
Abstract
There is significant variability in lung transplant centers’ approach to HLA (human leukocyte antigen) antibodies, creating heterogeneity regarding their clinical significance. Some institutions use beads coated with multiple HLA to screen candidate sera and then use single antigen beads (SAB) to determine antibody identity if the pre‐screen is positive. Other centers do not pre‐screen, using SAB alone, which may detect low‐level antibodies of unknown significance. The primary objective of this study was to review the current literature to identify sources of heterogeneity in the identification of pre‐ a...
Source: Tissue Antigens - November 25, 2017 Category: Allergy & Immunology Authors: A. Courtwright, J. M. Diamond, I. Wood, I. Guleria, E. Milford, S. El ‐Chemaly, H. J. Goldberg Tags: ORIGINAL ARTICLE Source Type: research
Single molecule real ‐time (SMRT®) DNA sequencing of HLA genes at ultra‐high resolution from 126 International HLA and Immunogenetics Workshop cell lines
Abstract
The hyperpolymorphic HLA genes play important roles in disease and transplantation and act as genetic markers of migration and evolution. A panel of 107 B‐lymphoblastoid cell lines (B‐LCLs) was established in 1987 at the 10th International Histocompatibility Workshop as a resource for the immunogenetics community. These B‐LCLs are well characterised and represent diverse ethnicities and HLA haplotypes. Here we have applied Pacific Biosciences’ Single Molecule Real‐Time (SMRT) DNA sequencing to HLA type 126 B‐LCL, including the 107 IHIW cells, to ultra‐high resolution. Amplicon sequencing of full‐le...
Source: Tissue Antigens - November 24, 2017 Category: Allergy & Immunology Authors: T. R. Turner, J. D. Hayhurst, D. R. Hayward, W. P. Bultitude, D. J. Barker, J. Robinson, J. Alejandro Madrigal, N. P. Mayor, S. G. E. Marsh Tags: ORIGINAL ARTICLE Source Type: research
Human leukocyte antigens: key regulators of T ‐cell mediated drug hypersensitivity
Abstract
Adverse drug reactions (ADR) can be broadly categorised as either on‐target or off‐target. On‐target ADRs arise as a direct consequence of the pharmacological properties of the drug and are therefore predictable and dose dependant. On‐target ADRs comprise the majority (>80%) of ADRs, relate to the drug's interaction with its known pharmacological target and are a result of a complex interplay of genetic and ecologic factors. In contrast off‐target ADRs, including immune mediated ADRs (IM‐ADRs), are due to unintended pharmacological interactions such as inadvertent ligation of host cell receptors or ...
Source: Tissue Antigens - November 24, 2017 Category: Allergy & Immunology Authors: A. J. Redwood, R. K. Pavlos, K. D. White, E. J. Phillips Tags: REVIEW ARTICLE Source Type: research
A novel HLA ‐A*26 allele, HLA‐A*26:01:44, identified in a Caucasian individual
HLA‐A*26:01:44 differs from HLA‐A*26:01:01 by a single substitution in exon 5. (Source: Tissue Antigens)
Source: Tissue Antigens - November 23, 2017 Category: Allergy & Immunology Authors: A. A. Mostafa, M. Petrosenko, L. Stamm, F. Khan, N. Berka Tags: NEW ALLELE ALERTS Source Type: research
Identification of two new HLA class I alleles in Italian bone marrow donors: A*31:125 and B*44:269
Two novel alleles, HLA‐A*31:125 and HLA‐B*44:269, are described in Italian bone marrow donors. (Source: Tissue Antigens)
Source: Tissue Antigens - November 23, 2017 Category: Allergy & Immunology Authors: R. Sciarrino, S. Fornaciari, M. L. Mariotti, F. Scatena, M. Curcio Tags: NEW ALLELE ALERTS Source Type: research
Deciphering the fine nucleotide diversity of full HLA class I and class II genes in a well ‐documented population from sub‐Saharan Africa
This study unveils highly relevant information on the molecular evolution of HLA genes in relation to their immune function, calling for similar analyses in other populations living in contrasting environments. (Source: Tissue Antigens)
Source: Tissue Antigens - November 21, 2017 Category: Allergy & Immunology Authors: Thomas Goeury, Lisa Creary, Lydie Brunet, Maxime Galan, Maeva Pasquier, Barbara Kervaire, Andr é Langaney, Jean‐Marie Tiercy, Marcelo A. Fernández‐Viña, José Manuel Nunes, Alicia Sanchez‐Mazas Tags: ORIGINAL ARTICLE Source Type: research
Saddlebags: A Software Interface for Submitting Full ‐Length HLA Allele Sequences to the EMBL‐ENA Nucleotide Database
Abstract
Submission of full‐length HLA allele sequences presents a unique challenge, both for high‐throughput sequencing laboratories, and smaller diagnostic laboratories. HLA’s extensive polymorphism means that accurate representation and annotation of allele sequence is of critical importance, and curators of nucleotide databases must establish submission formats to ensure high‐quality data, and prevent ambiguities. The IPD‐IMGT/HLA database is established as the standard repository for HLA sequences, and it is a major goal of the 17th International HLA and Immunogenetics Workshop to fill the IPD‐IMGT/HLA dat...
Source: Tissue Antigens - November 21, 2017 Category: Allergy & Immunology Authors: B.M. Matern, M. Groeneweg, C.E.M. Voorter, M.G.J. Tilanus Tags: ORIGINAL ARTICLE Source Type: research
The distribution of the DRB4*01:03:01:02N null allele in HLA ‐DRB1~DQB1 haplotypes in the Croatian population
In conclusion, the data presented in this paper should prompt other population studies focused on DRB3/4/5 genes and be used as a basis for future investigations of the clinical relevance of these genes in transplantation setting. (Source: Tissue Antigens)
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Authors: Z. Grubic, M. Maskalan, L. Radmanic, K. Š. Jankovic, M. B. Kamenaric, R. Zunec Tags: ORIGINAL ARTICLE Source Type: research
Nomenclature for factors of the HLA system, update September 2017
(Source: Tissue Antigens)
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Authors: S. G. E. Marsh, Tags: NOMENCLATURE UPDATE Source Type: research
Nomenclature for factors of the HLA system, update August 2017
(Source: Tissue Antigens)
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Authors: S. G. E. Marsh, Tags: NOMENCLATURE UPDATE Source Type: research
Nomenclature for factors of the HLA system, update July 2017
(Source: Tissue Antigens)
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Authors: S. G. E. Marsh, Tags: NOMENCLATURE UPDATE Source Type: research
Beyond disease susceptibility —Leveraging genome‐wide association studies for new insights into complex disease biology
Genetic studies in complex diseases have been highly successful, but have also been largely one‐dimensional: predominantly focusing on the genetic contribution to disease susceptibility. While this is undoubtedly important—indeed it is a pre‐requisite for understanding the mechanisms underlying disease development—there are many other important aspects of disease biology that have received comparatively little attention. In this review, I will discuss how existing genetic data can be leveraged to provide new insights into other aspects of disease biology, why such insights could change the way we think about comple...
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Authors: J. C. Lee Tags: REVIEW ARTICLE Source Type: research
Issue Information
(Source: Tissue Antigens)
Source: Tissue Antigens - November 20, 2017 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research
