The novel null allele, HLA ‐B*40:338N, was identified in a Chinese leukemia patient
Summary
HLA‐B*40:338N differs from HLA‐B*40:01:01 by a single nucleotide substitution at position 843 C>A. (Source: Tissue Antigens)
Source: Tissue Antigens - January 2, 2018 Category: Allergy & Immunology Authors: J. He, L. ‐N. Dong, F. Wang, W. Wang, F.‐M. Zhu Tags: NEW ALLELE ALERTS Source Type: research
Identification of a novel HLA ‐C allele, HLA‐C*15:151, in a Taiwanese individual
Abstract
One nucleotide substitution in codon 240 of HLA‐C*15:02:01:01 results in a novel allele, HLA‐C*15:151. (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: K. L. Yang, P. Y. Lin Tags: NEW ALLELE ALERTS Source Type: research
Resolving incomplete single nucleotide polymorphism tagging of HLA ‐DQ2.2 for coeliac disease genotyping using digital droplet PCR
Abstract
A hallmark of coeliac disease (CD) is the exceptionally strong genetic association with HLA‐DQ2.5, DQ8, and DQ2.2. HLA typing provides information on CD risk important to both clinicians and researchers. A method that enables simple and fast detection of all CD risk genotypes is particularly desirable for the study of large populations. SNP‐based HLA typing can detect the CD risk genotypes by detecting a combination of six SNPs but this approach can struggle to resolve HLA‐DQ2.2, seen in 4% of European CD patients, due to the low resolution of one negatively predicting SNP. We sought to optimise SNP‐based ...
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: M. Y. Hardy, N. Ontiveros, M. D. Varney, J. A. Tye ‐Din Tags: ORIGINAL ARTICLE Source Type: research
The full ‐length sequence of the HLA‐C allele, HLA‐C*03:40:01
Summary
Confirmed the full‐length sequence of HLA‐C*03:40:01 by cloning and sequencing in a Chinese donor. (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: L. Li, Z. Li, H. ‐Y. Zou Tags: NEW ALLELE ALERTS Source Type: research
Identification of a novel HLA ‐C*12 allele, HLA‐C*12:221
Abstract
HLA‐C*12:221 differs from C*12:02:03 by a single nucleotide substitution at position 367 of exon 3. (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: M. ‐R. Huo, Y. Yu, B. Xi, D. Li Tags: NEW ALLELE ALERTS Source Type: research
Microsatellite markers for evaluating the diversity of the Natural Killer Complex and Major Histocompatibility Complex genomic regions in domestic horses
Abstract
Genotyping microsatellite markers represents a standard, relatively easy and inexpensive method of assessing genetic diversity of complex genomic regions in various animal species, such as the major histocompatibility complex (MHC) and/or natural killer cell receptor (NKR) genes. MHC‐linked microsatellite markers have been identified and some of them were used for characterizing MHC polymorphism in various species, including horses. However, most of those were MHC class II markers, while MHC class I and III sub‐regions were less well covered. No tools for studying genetic diversity of NKR complex genomic regio...
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: C. Horecky, E. Horecka, J. Futas, E. Janova, P. Horin, A. Knoll Tags: ORIGINAL ARTICLE Source Type: research
Characterization of the novel HLA ‐B*40:01:31 allele
Abstract
The HLA‐B*40:01:31 allele differs from B*40:01:01 by one nucleotide substitution at position 216 . (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: J. W. Zheng, Y. Sun, J. H. Xie, D. Xiang Tags: NEW ALLELE ALERTS Source Type: research
Next Generation Sequencing Characterizes the Extent of HLA Diversity in an Argentinian Registry Population
Abstract
Next generation DNA sequencing is used to determine the HLA‐A, ‐B, ‐C, ‐DRB1, and –DQB1 assignments of 1472 unrelated volunteers for the unrelated donor registry in Argentina. The analysis characterized all HLA exons and introns for class I alleles; at least exons 2, 3 for HLA‐DRB1; and exons 2‐6 for HLA‐DQB1. Of the distinct alleles present, there are 330 class I and 98 class II. The majority (~98%) of the cumulative allele frequency at each locus is contributed by alleles that appear at a frequency of at least 1 in 1000. Fourteen (18.2%) of the 77 novel class I and II alleles carry nonsynonymous ...
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: C. K. Hurley, L. Hou, A. Lazaro, J. Gerfen, E. Enriquez, P. Galarza, M. Belen Rodriguez Cardozo, M. Halagan, M. Maiers, D. Behm, J. Ng Tags: ORIGINAL ARTICLE Source Type: research
The full ‐length sequence of the HLA‐C allele, HLA‐C*03:02:01
Summary
Confirmed the full‐length sequence of HLA‐C*03:02:01 by cloning and sequencing in a Chinese donor. (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: Z. Li, H. ‐Y. Zou Tags: NEW ALLELE ALERTS Source Type: research
The full ‐length sequence of the HLA‐C allele, HLA‐C*15:13:01:01
Summary
Confirmed the full‐length sequence of HLA‐ C*15:13:01:01 by cloning and sequencing in a Chinese donor. (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: Z. Li, H. ‐Y. Zou, D. Zhou Tags: NEW ALLELE ALERTS Source Type: research
A novel allele, HLA ‐B*51:220, identified in an individual from south of Brazil
Abstract
Novel allele, HLA‐B*51:220 generated by a gene conversion event was identified in a Brazilian individual. (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: J. E. L. Visentainer, T. R. Turner, E. Nascimento, R. L. S. Maior, R. A. Fabreti ‐Oliveira Tags: NEW ALLELE ALERTS Source Type: research
Description of the novel KIR2DL4*039 allele identified in a southern Chinese Han individual
Abstract
The novel KIR2DL4*039 allele differs from the closest allele 2DL4*00602 by a single nonsynonymous mutation. (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: Z. ‐H. Deng, S.‐Q. Cai, R. Chen Tags: NEW ALLELE ALERTS Source Type: research
Identification of a novel allele, HLA ‐A*03:289, by sequence based typing in Lithuanian patient
SUMMARY STATEMENT
Amino acid substitution Val165Leu of the HLA‐A*03:01:01 results in a novel allele, HLA‐A*03:289. (Source: Tissue Antigens)
Source: Tissue Antigens - January 1, 2018 Category: Allergy & Immunology Authors: B. Valatkaite ‐Rakstiene, R. Cekauskiene, L. Griskevicius, A. Jakubauskas Tags: NEW ALLELE ALERTS Source Type: research
The HLA ‐G 14bp insertion/deletion polymorphism and its association with soluble HLA‐G levels in women with recurrent miscarriages
Abstract
Human leucocyte antigen‐G (HLA‐G), a non classical class Ib gene is mainly expressed on extravillous trophoblasts at the fetal‐maternal interface. HLA‐G molecule is considered to play an important role in maternal immune suppression during pregnancy. 14bp insertion/deletion polymorphism (rs66554220) in exon 8 of the HLA‐G gene influences HLA‐G mRNA stability and isoform splicing patterns. In the present study, 202 RM women with two or more than two consecutive miscarriages, their 202 partners and 204 fertile control women with at least one live birth and no miscarriages were analyzed for 14bp insertion...
Source: Tissue Antigens - December 27, 2017 Category: Allergy & Immunology Authors: V. Kalotra, M. Lall, I. C. Verma, A. Kaur, A. Kaur Tags: ORIGINAL ARTICLE Source Type: research
Quantification of classical HLA class I mRNA by allele ‐specific, real‐time polymerase chain reaction for most Han individuals
This study provides a tool for detecting the comprehensive expression profile of HLA class I alleles and will be useful not only for the investigation of the molecular mechanism underlying HLA allele expression regulation but also for exploration of immunological mechanisms involving HLA expression in the fields of tumour immune evasion, viral infection, auto‐immune disorders, and graft vs host disease after haematopoietic stem cell transplantation. (Source: Tissue Antigens)
Source: Tissue Antigens - December 27, 2017 Category: Allergy & Immunology Authors: N. Pan, S. Lu, W. Wang, F. Miao, H. Sun, S. Wu, D. Nan, J. Qiu, J. Xu, J. Zhang Tags: ORIGINAL ARTICLE Source Type: research
