Strain ‐based HLA association analysis identified HLA‐DRB1*09:01 associated with modern strain tuberculosis
This study investigated the possible association of HLA class II genes with TB caused by modern and ancient Mycobacterium tuberculosis (MTB). The study included 682 patients with TB and 836 control subjects who were typed for
HLA‐DRB1
and
HLA‐DQB1
alleles. MTB strains were classified using a large sequence polymorphism typing method. Association analysis was performed using common HLA alleles and haplotypes in different MTB strains. HLA association analysis of patients infected with modern MTB strains showed significant association for
HLA‐DRB1*09:01 (odds ratio [OR] = 1.82; P‐value = 9.88 × 10−4) and
HLA‐DQB1*03:03 alleles (OR = 1.76; P‐value = 1.31 × 10−3) with susceptibility to TB. Haplotype analysis confirmed that these alleles were in strong linkage disequilibrium and did not exert an interactive effect. Thus, the results of this study showed an association between HLA class II genes and susceptibility to TB caused by modern MTB strains, suggesting the importance of strain‐specific analysis to determine susceptibility genes associated with TB.
Source: Tissue Antigens - Category: Allergy & Immunology Authors: L. Toyo ‐oka, S. Mahasirimongkol, H. Yanai, T. Mushiroda, S. Wattanapokayakit, N. Wichukchinda, N. Yamada, N. Smittipat, T. Juthayothin, P. Palittapongarnpim, S. Nedsuwan, P. Kantipong, A. Takahashi, M. Kubo, P. Sawanpanyalert, K. Tokunaga Tags: ORIGINAL ARTICLE Source Type: research