Effects of weak/non ‐complement‐binding HLA antibodies on C1q‐binding

In conclusion, if targeting the same epitope, an excess of IgG2/4 is repressing the extent of IgG1/3 triggered C1q‐binding in vitro. Such IgG subclass constellations are present in about a third of sensitized patients and their net effect on C1q‐binding is slightly inhibitory.

Source: Tissue Antigens - June 5, 2017 Category: Allergy & Immunology Authors: G. H önger, P. Amico, M.‐L. Arnold, B. M. Spriewald, S. Schaub Tags: ORIGINAL ARTICLE Source Type: research