Sentinel node biopsy in patients with primary cutaneous melanoma of any thickness: A cost-effectiveness analysis
To assess the cost-effectiveness of the sentinel node biopsy with lymphadenectomy for nodal metastases (SNB) in patients with primary cutaneous melanoma (CM) of different Breslow thickness (intermediate, thick, thin). (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Patricia Serra-Arbeloa, Ángel Orlando Rabines-Juárez, María Soledad Álvarez-Ruiz, Francisco Guillén-Grima Source Type: research
Obesity and colorectal liver metastases: Mechanisms and management
Colorectal cancer (CRC) is the third commonest malignancy after lung and breast cancer. The most common cause of mortality from CRC is from distant metastases. Obesity is a known risk factor for primary CRC development. However, its role in metastatic disease progression is not fully understood. The article aims to provide an overview of the role of obesity in colorectal liver metastases (CRLM). Furthermore, possible strategies to minimise this effect are discussed.An electronic search of MedLine, EMBASE, CINAHL and google scholar was performed. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Samir Pathak, Sanjay Pandanaboyana, Ian Daniels, Neil Smart, K.R. Prasad Source Type: research
Biologic mesh spacer placement facilitates safe delivery of dose-intense radiation therapy: A novel treatment option for unresectable liver tumors
The liver is a common site of metastasis for intra-abdominal malignancies [1]. Surgery continues to demonstrate better disease-free and overall survival for metastatic liver disease when technically feasible [2]. Liver directed therapies and systemic chemotherapy are utilized when resection is not possible with variable results [2]. There remain challenges when the liver lesions are too large, close to major vessels and when patient tolerance prohibits palliative chemotherapy. Traditionally, radiation therapy (RT) has not been considered a good option for the treatment of liver metastases due to the liver's poor tolerance ...
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Hishaam Nabil Ismael, Christopher H. Crane, Prajnan Das, Sunil Krishnan, Rashna T. Schroff, Milind Javle, Claudius Conrad, Jean-Nicolas Vauthey, Thomas Aloia Source Type: research
Usefulness of three-dimensional(3D) simulation software in hepatectomy for pediatric hepatoblastoma
Hepatoblastoma (HB) is the most common malignant liver tumor in childhood. Complete HB surgical resection which is technically demanding is the cornerstone of effective therapy with a good prognosis. The aim of our study is to evaluate the usefulness of 3D simulation software in assisting hepatectomy in pediatric patients with HB. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Gang Zhang, Xian-jun Zhou, Cheng-zhan Zhu, Qian Dong, Lin Su Source Type: research
Complete mesocolic excision and central vascular ligation for colon cancer: Principle, anatomy, surgical technique, and outcomes
Classic colon cancer surgery refers to a wide resection of the tumor-bearing segment and the lymphatics draining along the named artery. The concept of TME has been applied to colon cancer and complete mesocolic excision (CME) in conjuction with central vascular ligation (CVL) has been introduced as the surgical treatment for colon cancer. Here, we discuss appropriate CME procedure with regard to the oncologic backgrounds, essential components, applied anatomy, laparoscopic technique, short-term, and oncologic outcomes. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Nam Kyu Kim, Young Wan Kim, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee Source Type: research
Hyperthermic intraperitoneal chemotherapy with paclitaxel or cisplatin in patients with stage III-C/IV ovarian cancer. Is there any difference?
To compare the results of the administration of HIPEC with Paclitaxel or Cisplatin after cytoreduction in patients with stage IIIC-IV ovarian cancer, especially focused on disease-free survival. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: P. Cascales-Campos, V. López-López, Gil J, J. Arévalo-Pérez, A. Nieto, F. Barceló, E. Gil, P. Parrilla Source Type: research
Predictors of survival in patients with surgical spine multiple myeloma metastases
Multiple myeloma (MM) is the most common primary malignant tumor of the spine and bone. Spinal metastases are part of the evolution and progression of the MM disease. Therefore, this study aims at investigating prognostic factors associated with overall survival (OS) in patients with symptomatic spine MM metastases. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Aymeric Amelot, Alexis Moles, Joseph Cristini, Celine Salaud, Cyrille Touzeau, Olivier Hamel, Eric Bord, Kevin Buffenoir Source Type: research
Trends in lymph node excision and impact of positive lymph node ratio in patients with colectomy for primary colon adenocarcinoma: Population based study 1988 to 2011
Studies suggest increased lymph node excision in patients with colon cancer portends improved survival. Guidelines recommend excising 12 or more lymph nodes during colectomy. There is an inverse correlation between the positive lymph node ratio and survival in patients of these patients. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Brandon Garcia, Carlos Guzman, Christopher Johnson, Nicholas J. Hellenthal, Daphne Monie, Jose Raul Monzon Source Type: research
Pharmacokinetics and the effect of heat on intraperitoneal pemetrexed using a murine model
Pemetrexed is a systemic chemotherapeutic agent used in the treatment of malignant mesothelioma. This drug represents a potentially promising intraperitoneal (IP) agent to use for hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal mesothelioma. However, this has yet to be supported by preclinical studies. Therefore, we aimed to study the effect of pemetrexed dose and perfusion temperature on the resultant pemetrexed concentration in 3 different compartments (systemic circulation, portal circulation and peritoneal tissues) using a murine model. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: David Badrudin, Camille Perrault-Mercier, Antoine Bouchard-Fortier, Julien Hubert, François A. Leblond, Lucas Sideris, Pierre Dubé Source Type: research
Lower-extremity lymphedema following management for endometrial and cervical cancer
Despite the alleged benefits conferred by a lymphadenectomy in the management of gynecologic malignancies, there are concerns regarding the development of postoperative lower-extremity lymphedema. The purpose of this study was to identify the incidence of lymphedema and associated risk factors in accordance with surgical staging during the management of endometrial and cervical cancer. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Alberto A. Mendivil, Mark A. Rettenmaier, Lisa N. Abaid, John V. Brown, John P. Micha, Katrina L. Lopez, Bram H. Goldstein Source Type: research
MicroRNA dysregulation in melanoma
Melanoma is the deadliest form of skin cancer. Current challenges facing the management of melanoma include accurate prediction of individuals who will respond to adjuvant therapies as well early detection of recurrences. These and other challenges have prompted investigation into biomarkers that could be used as diagnostic, prognostic and therapeutic aids. MicroRNAs (miRs) are small 19–22 nucleotide RNA inhibitors of protein translation. Over 800 different miRs are present within cells and importantly miR expression profiles may vary across different cells types and stages of malignancy. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Nicholas Latchana, Akaansha Ganju, J. Harrison Howard, William E. Carson Source Type: research
Molecular markers of prognosis and therapeutic targets in metastatic colorectal cancer
Metastatic disease ultimately occurs in approximately 50–70% of patients presenting with colorectal cancer. In patients with advanced disease, there is significant variability in individual patient outcomes. To improve understanding of tumor behavior, markers such as KRAS and BRAF mutation status are increasingly utilized. Additionally, newer surrogates of tumor biology, such as telomerase activity and the prevalence of circulating tumor cells and circulating tumor DNA, have generated increasing interest due to clinical potential. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Sean M. Ronnekleiv-Kelly, Richard A. Burkhart, Timothy M. Pawlik Source Type: research
Sentinel node biopsy in patients with primary cutaneous melanoma of any thickness: A cost-effectiveness analysis
To assess the cost-effectiveness of the sentinel node biopsy with lymphadenectomy for nodal metastases (SNB) in patients with primary cutaneous melanoma (CM) of different Breslow thickness (intermediate, thick, thin). (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Patricia Serra-Arbeloa, Ángel Orlando Rabines-Juárez, María Soledad Álvarez-Ruiz, Francisco Guillén-Grima Source Type: research
Obesity and colorectal liver metastases: Mechanisms and management
Colorectal cancer (CRC) is the third commonest malignancy after lung and breast cancer. The most common cause of mortality from CRC is from distant metastases. Obesity is a known risk factor for primary CRC development. However, its role in metastatic disease progression is not fully understood. The article aims to provide an overview of the role of obesity in colorectal liver metastases (CRLM). Furthermore, possible strategies to minimise this effect are discussed.An electronic search of MedLine, EMBASE, CINAHL and google scholar was performed. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Samir Pathak, Sanjay Pandanaboyana, Ian Daniels, Neil Smart, K. Raj Prasad Source Type: research
Biologic mesh spacer placement facilitates safe delivery of dose-intense radiation therapy: A novel treatment option for unresectable liver tumors
The liver is a common site of metastasis for intra-abdominal malignancies [1]. Surgery continues to demonstrate better disease-free and overall survival for metastatic liver disease when technically feasible [2]. Liver directed therapies and systemic chemotherapy are utilized when resection is not possible with variable results [2]. There remain challenges when the liver lesions are too large, close to major vessels and when patient tolerance prohibits palliative chemotherapy. Traditionally, radiation therapy (RT) has not been considered a good option for the treatment of liver metastases due to the liver's poor tolerance ...
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Hishaam Nabil Ismael, Christopher H. Crane, Prajnan Das, Sunil Krishnan, Rashna T. Schroff, Milind Javle, Claudius Conrad, Jean-Nicolas Vauthey, Thomas Aloia Source Type: research
