In vitro testing to a panel of potential chemotherapeutics and current concepts of chemotherapy in benign meningiomas
Treatment of benign meningiomas remains a challenge, especially when they involve the skull-base or when surgery and radiation fail. Moreover, a recent in vitro MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) study testing hydroxyurea, temozolomide and other targeting agents failed to identify drugs effective in their treatment; therefore the search for further more effective agents continues. We performed a thorough review of in vitro investigations, animal studies and human clinical trials and endeavoured to integrate our results of MTT assay into current concepts of chemotherapy in benign mening...
Source: Surgical Oncology - June 13, 2015 Category: Surgery Authors: Vladimir Balik, Igor Sulla, Hun Ho Park, Marek Sarissky Source Type: research
In vitro testing to a panel of potential chemotherapeutics and current concepts of chemotherapy in benign meningiomas
Treatment of benign meningiomas remains a challenge, especially when they involve the skull-base or when surgery and radiation fail. Moreover, a recent in vitro MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) study testing hydroxyurea, temozolomide and other targeting agents failed to identify drugs effective in their treatment; therefore the search for further more effective agents continues. We performed a thorough review of in vitro investigations, animal studies and human clinical trials and endeavoured to integrate our results of MTT assay into current concepts of chemotherapy in benign meningio...
Source: Surgical Oncology - June 13, 2015 Category: Surgery Authors: Vladimir Balik, Igor Sulla, Hun Ho Park, Marek Sarissky Source Type: research
An overview of triple negative breast cancer for Surgical Oncologists
Triple negative breast cancers (TNBCs) represent a distinct subgroup of breast cancers with an immunohistochemical phenotype that is negative for oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2). The aim of this article is to provide a broad overview of recent developments in the diagnosis and management of TNBC for surgical oncologists. This overview discusses the subtypes of TNBC and the relationship between this type of breast cancer and the BRCA1 gene. (Source: Surgical Oncology)
Source: Surgical Oncology - June 13, 2015 Category: Surgery Authors: Shiva Sharma, Mitchel Barry, David J. Gallagher, Malcolm Kell, Virgilio Sacchini Source Type: research
Is Radioembolization (Y) better than doxorubicin drug eluting beads (DEBDOX) for hepatocellular carcinoma with portal vein thrombosis? A retrospective analysis
This study compares radioembolization (90Y) versus doxorubicin drug eluting beads (DEBDOX) in the treatment of unresectable hepatocellular carcinoma with portal vein thrombosis. (Source: Surgical Oncology)
Source: Surgical Oncology - June 13, 2015 Category: Surgery Authors: Olaguoke Akinwande, Daniel Kim, Jacob Edwards, Russell Brown, Prejesh Philips, Charles Scoggins, Robert C.G. Martin Source Type: research
Management of colon cancer in patients with cirrhosis: a review
The incidence of cirrhosis is increasing in parallel with that of hepatitis C and non-alcoholic steatohepatitis. Patients with colon cancer and liver cirrhosis constitute an important at-risk group. Many colorectal surgeons and oncologists are not familiar with the management of colon cancer in patients with cirrhosis. Here, we review the literature on the management and prognosis of patients with both colon cancer and cirrhosis. (Source: Surgical Oncology)
Source: Surgical Oncology - June 13, 2015 Category: Surgery Authors: C. Sabbagh, C. Cosse, Bruno Chauffert, E. Nguyen-Khac, Jean-Paul Joly, Thierry Yzet, J.M. Regimbeau Tags: Review Source Type: research
Quantitative thallium scintigraphy for prediction of histological response to neoadjuvant chemotherapy in osteosarcoma; systematic review and meta-analysis
The objective of this systematic review is to provide an up-to-date and unprecedented summary of the value of 201thallium (201Tl) scintigraphy for the preoperative evaluation of the chemotherapy response of osteosarcoma. (Source: Surgical Oncology)
Source: Surgical Oncology - June 13, 2015 Category: Surgery Authors: Tadahiko Kubo, Shoji Shimose, Jun Fujimori, Taisuke Furuta, Mitsuo Ochi Source Type: research
Minimally Invasive Esophagectomy: Lateral decubitus vs. prone positioning; Systematic review and Pooled analysis
The uptake of minimally invasive esophagectomy (MIE) has increased vastly over the last decade, with proven short-term benefits over an open approach. The aim of this pooled analysis was to compare clinical outcomes of Minimally Invasive Esophagectomy (MIE) performed in the prone and lateral decubitus positions.A systematic literature search (2000–2015) was undertaken for publications that compared patients who underwent MIE in the lateral decubitus (LD) or prone (PR) positions. Weighted mean difference (WMD) was calculated for the effect size of LD positioning on continuous variables and Pooled odds ratios (POR) for dis...
Source: Surgical Oncology - June 10, 2015 Category: Surgery Authors: Sheraz R. Markar, Tom Wiggins, Stefan Antonowicz, Emmanouil Zacharakis, George B. Hanna Source Type: research
High co-expression of Sp1 and HER-2 is correlated with poor prognosis of gastric cancer patients
We examined the HER-2 overexpression and amplification and expression levels of Sp1 in 227 GC patients using immune-histochemical staining and fluorescence in situ hybridization. Data on clinicopathological features and relevant prognostic factors in these patients were analyzed. Of the 227 gastric cancer samples, 11.89% were positive for Her-2 overexpression/amplification under the new scoring system, and the frequency of negative, weak positive and strong positive expression of Sp1 was 14.98%, 48.01 % and 37.0% respectively. (Source: Surgical Oncology)
Source: Surgical Oncology - June 3, 2015 Category: Surgery Authors: Weihua Jiang, Ziliang Jin, Fei Zhou, Jiujie Cui, Lei Wang, Liwei Wang Tags: Review Source Type: research
Editorial Board/Aims and Scope
(Source: Surgical Oncology)
Source: Surgical Oncology - June 1, 2015 Category: Surgery Source Type: research
Minimally Invasive Surgery For Femoral Neck Fractures Using Bone Cement Infusible Hollow-Perforated Screw In High-Risk Patients With Advanced Cancer
Pathologic or osteoporotic femoral neck fractures usually treated with joint replacement surgery rather than joint-preserving surgery because multiple screw fixation has a high risk for fixation failure and nonunion as well as the need for a postoperative protection period. However, joint-preserving surgery might be preferable in high-risk patients with short life expectancy due to advanced disease. Recently introduced hollow-perforated screws are devices for achieving percutaneous fixation by simultaneous injection to the weak bone area through its multiple side holes. (Source: Surgical Oncology)
Source: Surgical Oncology - May 21, 2015 Category: Surgery Authors: Patrick P. Lin, Hyun Guy Kang, Yong-il Kim, June Hyuk Kim, Han Soo Kim Tags: Review Source Type: research
Ratio and Log Odds of Positive Lymph Nodes in Breast Cancer Patients with Mastectomy
This study aimed to investigate the predictive role of lymph nodes (LNs) and assess the prognostic significance of the ratio of positive LNs (LNR) and log odds of positive LNs (LODDS) in breast cancer patients who have undergone a mastectomy. (Source: Surgical Oncology)
Source: Surgical Oncology - May 18, 2015 Category: Surgery Authors: Yao-Jen Chang, Kuo-Piao Chung, Li-Ju Chen, Yun-Jau Chang Tags: Review Source Type: research
The role of pancreatic stellate cells in pancreatic cancer
The prognosis of pancreatic cancer remains desperately poor, with little progress made over the past 30 years despite the development of new combination chemotherapy regimens. Stromal activity is especially prominent in the tissue surrounding pancreatic tumours, and has a profound influence in dictating tumour development and dissemination. Pancreatic stellate cells (PaSCs) have a key role in this tumour microenvironment, and have been the subject of much research in the past decade. This review examines the relationship between PaSCs and cancer cells. (Source: Surgical Oncology)
Source: Surgical Oncology - May 18, 2015 Category: Surgery Authors: John AG. Moir, Jelena Mann, Steve A. White Tags: Review Source Type: research
The incidence and prognosis of true duodenal carcinomas
Primary duodenal carcinoma (PDC) is a rare gastrointestinal tumor. The difficult distinction between PDC and other types of carcinoma (e.g. within the periampullary region) is reflected in the scarce literature on true duodenal carcinomas. However, this distinction may be important in relation to the overall prognosis as well as in the choice of adjuvant or palliative treatment strategies. The aim of this study was to evaluate the incidence, management and prognosis of patients with true PDC within a well-defined geographical area. (Source: Surgical Oncology)
Source: Surgical Oncology - April 22, 2015 Category: Surgery Authors: T. Buchbjerg, C. Fristrup, M.B. Mortensen Tags: Review Source Type: research
Total Thyroidectomy versus Lobectomy as Initial Operation for Small Unilateral Papillary Thyroid Carcinoma: A Meta-Analysis
Consensus guidelines have recommended total thyroidectomy for papillary thyroid carcinoma (PTC) > 1 cm. However, the optimal surgical approach for small and unilateral ( (Source: Surgical Oncology)
Source: Surgical Oncology - April 22, 2015 Category: Surgery Authors: Francisco Igor B. Macedo, Vijay K. Mittal Source Type: research
Gene analysis techniques and susceptibility gene discovery in non-BRCA1/BRCA2 familial breast cancer
Breast cancer is the leading cause of cancer deaths in females worldwide occurring in both hereditary and sporadic forms. Women with inherited pathogenic mutations in the BRCA1 or BRCA2 genes have up to an 85% risk of developing breast cancer in their lifetimes. These patients are candidates for risk-reduction measures such as intensive radiological screening, prophylactic surgery or chemoprevention. However, only about 20% of familial breast cancer cases are attributed to mutations in BRCA1 and BRCA2, while a further 5–10% are attributed to mutations in other rare susceptibility genes such as TP53, STK11, PTEN, ATM and ...
Source: Surgical Oncology - April 13, 2015 Category: Surgery Authors: Fatima Aloraifi, Michael R. Boland, Andrew J. Green, James G. Geraghty Tags: Review Source Type: research
