Enterocutaneous fistula in patients with peritoneal malignancy following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Incidence, management and outcomes
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an effective treatment for peritoneal carcinomatosis (PC) from multiple origins, however is associated with increased complications compared to conventional gastrointestinal surgery. The aetiology of enterocutaneous fistulas (ECF) in most cases is a result of various contributing factors and therefore remains a major clinical problem, occurring in 4 –34% of patients post-CRS. The aim of this study was to analyze the incidence and outcome of ECF following CRS/HIPEC. (Source: Surgical Oncology)
Source: Surgical Oncology - May 23, 2016 Category: Surgery Authors: Sarah J. Valle, Nayef Alzahrani, Saleh Alzahrani, Thamer Bin Traiki, Winston Liauw, David L. Morris Source Type: research
Low CDX1 expression predicts a poor prognosis for hepatocellular carcinoma patients after hepatectomy
The caudal-type homeobox 1 (CDX1) transcription factor is a member of the caudal-related homeobox transcription factor gene family and has been reported to be down-regulated in a variety of cancers. However, the expression status and significance of CDX1 in hepatocellular carcinoma (HCC) is still controversial, and little is known about the role of CDX1 in HCC ·In our previous study, we investigated the expression and clinical significance of CDX1 in HCC samples from 313 HCC patients. We found CDX1 was strikingly down-regulated in HCC samples. (Source: Surgical Oncology)
Source: Surgical Oncology - May 23, 2016 Category: Surgery Authors: Hao Zheng, Yuan Yang, Meng-chao Wang, Sheng-xian Yuan, Tao Tian, Jun Han, Jun-sheng Ni, Jian Wang, Hao Xing, Wei-ping Zhou Source Type: research
Prognostic factors of gingival-alveolar squamous cell carcinoma of the maxilla
To determine prognostic factors in gingivo-alveolar squamous cell carcinoma of the maxilla (GA-SCC-M), and particulary the prognostic value of both vertical and antero-posterior tumor spread. (Source: Surgical Oncology)
Source: Surgical Oncology - May 23, 2016 Category: Surgery Authors: A. Morice, A. Ostertag, M. Sahli-amor, P. Goudot, C. Bertolus, T. Schouman Tags: Review Source Type: research
Enterocutaneous fistula in patients with peritoneal malignancy following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an effective treatment for peritoneal carcinomatosis (PC) from multiple origins, however is associated with increased complications compared to conventional gastrointestinal surgery. The aetiology of enterocutaneous fistulas (ECF) in most cases is a result of various contributing factors and therefore remains a major clinical problem, occurring in 4–34% of patients post-CRS. The aim of this study was to analyze the incidence and outcome of ECF following CRS/HIPEC. (Source: Surgical Oncology)
Source: Surgical Oncology - May 23, 2016 Category: Surgery Authors: Sarah J. Valle, Saleh Alzahrani, Nayef Alzahrani, Akshat Saxena, Thamer Bin Traiki, Winston Liauw, David L. Morris Source Type: research
Low CDX1 expression predicts a poor prognosis for hepatocellular carcinoma patients after hepatectomy
The caudal-type homeobox 1 (CDX1) transcription factor is a member of the caudal-related homeobox transcription factor gene family and has been reported to be down-regulated in a variety of cancers. However, the expression status and significance of CDX1 in hepatocellular carcinoma (HCC) is still controversial, and little is known about the role of CDX1 in HCC·In our previous study, we investigated the expression and clinical significance of CDX1 in HCC samples from 313 HCC patients. We found CDX1 was strikingly down-regulated in HCC samples. (Source: Surgical Oncology)
Source: Surgical Oncology - May 23, 2016 Category: Surgery Authors: Hao Zheng, Yuan Yang, Meng-chao Wang, Sheng-xian Yuan, Tao Tian, Jun Han, Jun-sheng Ni, Jian Wang, Hao Xing, Wei-ping Zhou Source Type: research
Evaluation and management of the pregnant patient with suspected primary musculoskeletal tumor or metastatic carcinoma to bone
Primary musculoskeletal cancer and metastatic disease to bone in pregnant patients presents major treatment challenges. Although uncommon, musculoskeletal malignancies in pregnant women have been reported. When diagnosing and treating these patients, the mother ’s health must be managed appropriately while ensuring that fetal development is not deleteriously affected. Extensive radiographic imaging and more advanced techniques are often necessary to fully characterize the extent of disease. When possible, magnetic resonance imaging should be used instead of computed tomography to limit exposure of the conceptus to radia...
Source: Surgical Oncology - May 20, 2016 Category: Surgery Authors: Varun Puvanesarajah, Andrea M. Spiker, Brett A. Shannon, Maureen Grundy, Adam S. Levin, Carol D. Morris Tags: Review Source Type: research
Evaluation and management of the pregnant patient with suspected primary musculoskeletal tumor or metastatic carcinoma to bone
Primary musculoskeletal cancer and metastatic disease to bone in pregnant patients presents major treatment challenges. Although uncommon, musculoskeletal malignancies in pregnant women have been reported. When diagnosing and treating these patients, the mother's health must be managed appropriately while ensuring that fetal development is not deleteriously affected. Extensive radiographic imaging and more advanced techniques are often necessary to fully characterize the extent of disease. When possible, magnetic resonance imaging should be used instead of computed tomography to limit exposure of the conceptus to radiation...
Source: Surgical Oncology - May 20, 2016 Category: Surgery Authors: Varun Puvanesarajah, Andrea M. Spiker, Brett A. Shannon, Maureen Grundy, Adam S. Levin, Carol D. Morris Tags: Review Source Type: research
Complete mesocolic excision and central vascular ligation for colon cancer: Principle, anatomy, surgical technique, and outcomes
Classic colon cancer surgery refers to a wide resection of the tumor-bearing segment and the lymphatics draining along the named artery. The concept of TME has been applied to colon cancer and complete mesocolic excision (CME) in conjuction with central vascular ligation (CVL) has been introduced as the surgical treatment for colon cancer. Here, we discuss appropriate CME procedure with regard to the oncologic backgrounds, essential components, applied anatomy, laparoscopic technique, short-term, and oncologic outcomes. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Nam Kyu Kim, Young Wan Kim, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee Tags: Review Source Type: research
Hyperthermic intraperitoneal chemotherapy with paclitaxel or cisplatin in patients with stage III-C/IV ovarian cancer. Is there any difference?
To compare the results of the administration of HIPEC with Paclitaxel or Cisplatin after cytoreduction in patients with stage IIIC-IV ovarian cancer, especially focused on disease-free survival. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: P. Cascales-Campos, V. L ópez-López, J. Gil, J. Arévalo-Pérez, A. Nieto, F. Barceló, E. Gil, P. Parrilla Source Type: research
Predictors of survival in patients with surgical spine multiple myeloma metastases
Multiple myeloma (MM) is the most common primary malignant tumor of the spine and bone. Spinal metastases are part of the evolution and progression of the MM disease. Therefore, this study aims at investigating prognostic factors associated with overall survival (OS) in patients with symptomatic spine MM metastases. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Aymeric Amelot, Alexis Moles, Joseph Cristini, Celine Salaud, Cyrille Touzeau, Olivier Hamel, Eric Bord, Kevin Buffenoir Source Type: research
Trends in lymph node excision and impact of positive lymph node ratio in patients with colectomy for primary colon adenocarcinoma: Population based study 1988 to 2011
Studies suggest increased lymph node excision in patients with colon cancer portends improved survival. Guidelines recommend excising 12 or more lymph nodes during colectomy. There is an inverse correlation between the positive lymph node ratio and survival in patients of these patients. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Brandon Garcia, Carlos Guzman, Christopher Johnson, Nicholas J. Hellenthal, Daphne Monie, Jose Raul Monzon Source Type: research
Pharmacokinetics and the effect of heat on intraperitoneal pemetrexed using a murine model
Pemetrexed is a systemic chemotherapeutic agent used in the treatment of malignant mesothelioma. This drug represents a potentially promising intraperitoneal (IP) agent to use for hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal mesothelioma. However, this has yet to be supported by preclinical studies. Therefore, we aimed to study the effect of pemetrexed dose and perfusion temperature on the resultant pemetrexed concentration in 3 different compartments (systemic circulation, portal circulation and peritoneal tissues) using a murine model. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: David Badrudin, Camille Perrault-Mercier, Antoine Bouchard-Fortier, Julien Hubert, Fran çois A. Leblond, Lucas Sideris, Pierre Dubé Source Type: research
Lower-extremity lymphedema following management for endometrial and cervical cancer
Despite the alleged benefits conferred by a lymphadenectomy in the management of gynecologic malignancies, there are concerns regarding the development of postoperative lower-extremity lymphedema. The purpose of this study was to identify the incidence of lymphedema and associated risk factors in accordance with surgical staging during the management of endometrial and cervical cancer. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Alberto A. Mendivil, Mark A. Rettenmaier, Lisa N. Abaid, John V. Brown, John P. Micha, Katrina L. Lopez, Bram H. Goldstein Source Type: research
MicroRNA dysregulation in melanoma
Melanoma is the deadliest form of skin cancer. Current challenges facing the management of melanoma include accurate prediction of individuals who will respond to adjuvant therapies as well as early detection of recurrences. These and other challenges have prompted investigation into biomarkers that could be used as diagnostic, prognostic and therapeutic aids. MicroRNAs (miRs) are small 19 –22 nucleotide RNA inhibitors of protein translation. Over 800 different miRs are present within cells and importantly miR expression profiles may vary across different cells types and stages of malignancy. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Nicholas Latchana, Akaansha Ganju, J. Harrison Howard, William E. Carson Source Type: research
Molecular markers of prognosis and therapeutic targets in metastatic colorectal cancer
Metastatic disease ultimately occurs in approximately 50 –70% of patients presenting with colorectal cancer. In patients with advanced disease, there is significant variability in individual patient outcomes. To improve understanding of tumor behavior, markers such as KRAS and BRAF mutation status are increasingly utilized. Additionally, newer surrogate s of tumor biology, such as telomerase activity and the prevalence of circulating tumor cells and circulating tumor DNA, have generated increasing interest due to clinical potential. (Source: Surgical Oncology)
Source: Surgical Oncology - May 19, 2016 Category: Surgery Authors: Sean M. Ronnekleiv-Kelly, Richard A. Burkhart, Timothy M. Pawlik Source Type: research
