Outcomes of Curettage and Anhydrous Alcohol Adjuvant for Low-Grade Chondrosarcoma of Long Bone
Low-grade chondrosarcoma of long bones can be treated successfully with extended intralesional curettage using adjuvants. However, there is no study reporting the use of anhydrous alcohol as an adjuvant in the treatment of low-grade chondrosarcoma. We asked (1) whether intralesional curettage and anhydrous alcohol adjuvant for low-grade chondrosarcoma is associated with good oncologic outcomes; and we report (2) the complications of the procedure. (Source: Surgical Oncology)
Source: Surgical Oncology - April 13, 2015 Category: Surgery Authors: Wanlim Kim, Ilkyu Han, Eo Jin Kim, Seungcheol Kang, Han-Soo Kim Source Type: research
Is the Age of Genetic Surgery Finally Upon Us?
This review discusses gene editing and its potential in oncology. Gene editing has not evolved faster towards clinical application because of its difficulty in implementation. There have been many limitations of the tools thought to be useful in therapeutic gene editing. However, recently the combinatorial use of multiple biological tools appears to have broken the barrier impending clinical development.This review gives a short primer on gene editing followed by some of the foundational work in gene editing and subsequently a discussion of programmable nucleases leading to a description of Zinc Finger Nuclease, TALENs and...
Source: Surgical Oncology - April 13, 2015 Category: Surgery Authors: Eric B. Kmiec, Nicholas J. Petrelli Tags: Review Source Type: research
Gene analysis techniques and susceptibility gene discovery in non-BRCA1/BRCA2 familial breast cancer
Breast cancer is the leading cause of cancer deaths in females worldwide occurring in both hereditary and sporadic forms. Women with inherited pathogenic mutations in the BRCA1 or BRCA2 genes have up to an 85% risk of developing breast cancer in their lifetimes. These patients are candidates for risk-reduction measures such as intensive radiological screening, prophylactic surgery or chemoprevention. However, only about 20% of familial breast cancer cases are attributed to mutations in BRCA1 and BRCA2, while a further 5-10% are attributed to mutations in other rare susceptibility genes such as TP53, STK11, PTEN, ATM and CH...
Source: Surgical Oncology - April 13, 2015 Category: Surgery Authors: Fatima Aloraifi, Michael R. Boland, Andrew J. Green, James G. Geraghty Source Type: research
Preoperative concurrent chemoradiotherapy followed by extrapleural pneumonectomy for patients with non-small cell lung cancer with malignant pleural effusion and/or pleural nodules: Ten-year results of a prematurely terminated single institute phase II trial
Malignant pleural effusion and/or pleural nodules are a final stage of disease extension of non-small cell lung cancer (NSCLC), which is currently classified as M1a-Stage IV disease. The role of surgery, especially extrapleural pneumonectomy (EPP) for local disease control and its impact on the survival of patients remains uncertain. (Source: Surgical Oncology)
Source: Surgical Oncology - March 26, 2015 Category: Surgery Authors: Masafumi Yamaguchi, Yukito Ichinose, Shinichiro Shimamatsu, Tsukihisa Yoshida, Gouji Toyokawa, Kaname Nosaki, Fumihiko Hirai, Takashi Seto, Mitsuhiro Takenoyama Tags: Review Source Type: research
Metastatic lymph node ratio successfully predicts prognosis in Western gastric cancer patients
Lymph node positivity is a strong prognostic indicator in many cancers including gastric cancer. The extent of surgical resection directly influences the number of lymph nodes available for staging, with the lesser D1 resection that is standard practice in non-Asian countries typically providing fewer nodes for analysis. The widely used AJCC TNM staging system has been criticized for under-staging and stage migration where fewer than 15 nodes are resected, which is often the case in these populations. (Source: Surgical Oncology)
Source: Surgical Oncology - March 25, 2015 Category: Surgery Authors: Onur C. Kutlu, Mitchell Watchell, Sharmila Dissanaike Tags: Review Source Type: research
A case-control study of stomach cancer in relation to in China
The purpose of our study was to investigate the association between green tea (Camellia sinensis) drinking habits and risk of stomach cancer in China. (Source: Surgical Oncology)
Source: Surgical Oncology - March 6, 2015 Category: Surgery Authors: Yue Wang, Hong Duan, Helen Yang Tags: Review Source Type: research
A case-control study of stomach cancer in relation to Camellia sinensis in China
The purpose of our study was to investigate the association between green tea (Camellia sinensis) drinking habits and risk of stomach cancer in China. (Source: Surgical Oncology)
Source: Surgical Oncology - March 6, 2015 Category: Surgery Authors: Yue Wang, Hong Duan, Helen Yang Source Type: research
Laparoscopy-Assisted versus Open Distal gastrectomy for early gastric cancer: a meta-analysis based on seven randomized controlled trials
This study aims to answer the superiority of comparing laparoscopy-assisted distal gastrectomy(LADG) with open distal gastrectomy(ODG) in the treatment early gastric cancer(EGC). (Source: Surgical Oncology)
Source: Surgical Oncology - March 4, 2015 Category: Surgery Authors: Yuan Deng, Yan Zhang, Tian-Kang Guo Source Type: research
Editorial Board/Aims and Scope
(Source: Surgical Oncology)
Source: Surgical Oncology - March 1, 2015 Category: Surgery Source Type: research
Surgical Oncology Reviewers: 2014
The Editor-in-Chief of Surgical Oncology would like to acknowledge the following people for their expert assistance in evaluating manuscript submissions in 2014. We apologise for any omissions, which are unintentional, and sincerely thank all reviewers for their continued support. (Source: Surgical Oncology)
Source: Surgical Oncology - March 1, 2015 Category: Surgery Source Type: research
Onco DX Colon Cancer Assay for Prediction of Recurrence Risk in Patients with Stage II and III Colon Cancer: A review of the evidence
Advances in molecular biology have enabled identification of tumor biomarkers that allow for individualized risk assessment for patients with cancer. Molecular predictors of clinical outcome can help inform discussion regarding the role of adjuvant chemotherapy in patients with resected colon cancer, such as those with stage II colon cancer in which the benefit of adjuvant therapy is controversial or those with stage III colon cancer who may have a lower risk of recurrence and less absolute benefit from oxaliplatin therapy. (Source: Surgical Oncology)
Source: Surgical Oncology - February 14, 2015 Category: Surgery Authors: Y. Nancy You, Rudolph B. Rustin, James D. Sullivan Tags: Review Source Type: research
Multivisceral Resections for Gastrointestinal Stromal Tumors: Are the Risks Justifiable?
Surgical resection is the cornerstone of treatment for non-metastatic gastrointestinal stromal tumors (GISTs). Multivisceral resection (MVR) for locally advanced tumors is often required to achieve negative margins. The purpose of this study was to review the peri-operative and long-term oncologic outcomes for patients who required MVR versus single-organ resection (SOR) for GISTs. (Source: Surgical Oncology)
Source: Surgical Oncology - February 4, 2015 Category: Surgery Authors: Jennifer M. Racz, Supreet Sunil, Daniel Abramowitz, Savtaj S. Brar, M. Carolina Jimenez, Arash Azin, Eshetu G. Atenafu, Timothy D. Jackson, Allan Okrainec, Fayez A. Quereshy Tags: Review Source Type: research
Goblet Cell Appendiceal Tumors – management dilemmas and long-term outcomes
Appendiceal Goblet cell tumors (GCT) are clinically more aggressive, and have a worse outcome than midgut neuroendocrine tumors (mNETs). Guidelines for management of GCTs are limited. (Source: Surgical Oncology)
Source: Surgical Oncology - January 28, 2015 Category: Surgery Authors: Roberta Elisa Rossi, Tu-Vinh Luong, Martyn Evan Caplin, Christina Thirlwell, Tim Meyer, Jorge Garcia-Hernandez, Alex Baneke, Dario Conte, Christos Toumpanakis Source Type: research
Use of an absorbable adhesion barrier for reconstruction of partial mastectomy defects in the upper quadrant of large ptotic breasts
We report a new oncoplastic technique using the absorbable Interceed® sheet for upper quadrant breast cancer in large ptotic breasts with no other flaps. (Source: Surgical Oncology)
Source: Surgical Oncology - January 28, 2015 Category: Surgery Authors: Jeeyeon Lee, Seokwon Lee, Younglae Jung, Youngtae Bae Tags: Editorial Source Type: research
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with oxaliplatin for peritoneal mesothelioma: Preliminary results and survival analysis
Peritoneal mesothelioma is a rare disease with poor prognosis. The present study reports single center experience with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy with oxaliplatin (HIPEC-OX) over an eight-year period. (Source: Surgical Oncology)
Source: Surgical Oncology - January 7, 2015 Category: Surgery Authors: Julien Hubert, Eva Thiboutot, Pierre Dubé, Alexis-Simon Cloutier, Pierre Drolet, Lucas Sideris Tags: Review Source Type: research
