Neurofilament in CSF--A biomarker of disease activity and long-term prognosis in multiple sclerosis
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Soelberg Sorensen, P., Sellebjerg, F. Tags: Editorial Source Type: research
Individual differences in depression are associated with abnormal function of the limbic system in multiple sclerosis patients
Conclusions:
Our study showed that individual differences in depression in MS patients were significantly associated with altered regional activity and functional connectivity patterns within the limbic system. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Riccelli, R., Passamonti, L., Cerasa, A., Nigro, S., Cavalli, S. M., Chiriaco, C., Valentino, P., Nistico, R., Quattrone, A. Tags: Original Research Papers Source Type: research
Prognostic indicators of secondary progression in a paediatric-onset multiple sclerosis cohort in Kuwait
Conclusions:
This study showed that POMS patients with brainstem/cerebellar presentation and a relatively higher age at MS onset had disposition for SPMS and warrant an aggressive therapeutic approach. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Akhtar, S., Alroughani, R., Ahmed, S. F., Al-Hashel, J. Y. Tags: Original Research Papers Source Type: research
Effect of fingolimod on cardiac autonomic regulation in patients with multiple sclerosis
Conclusions:
After an initial increase in parasympathetic regulation, continuous fingolimod dosing shifts cardiac autonomic regulation towards sympathetic predominance, especially in men. Careful follow-up of fingolimod-treated relapsing–remitting multiple sclerosis patients is warranted as sympathetic predominance associates generally with impaired outcome.
ClinicalTrials.cov: NCT01704183 (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Simula, S., Laitinen, T., Laitinen, T. M., Tarkiainen, T., Hartikainen, P., Hartikainen, J. E. Tags: Original Research Papers Source Type: research
A significant decrease in diagnosis of primary progressive multiple sclerosis: A cohort study
Conclusion:
The diagnosis of PPMS has significantly decreased in Sweden specifically after introduction of disease-modifying treatments. Such decrease can have severe impacts on the future research on PPMS. Our data also suggest that the current trend to emphasise presence or absence of inflammatory activity is already reflected in clinical practice. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Westerlind, H., Stawiarz, L., Fink, K., Hillert, J., Manouchehrinia, A. Tags: Original Research Papers Source Type: research
Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients
Conclusions:
DMF shifts the immunophenotypes of circulating T cells, causing a reduction of memory cells and a relative expansion of naïve cells, regardless of the absolute lymphocyte count. This may represent one mechanism of action of the drug. Lymphopenic patients had a disproportionate loss of CD8+ T-cells, which may affect their immunocompetence. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Longbrake, E. E., Ramsbottom, M. J., Cantoni, C., Ghezzi, L., Cross, A. H., Piccio, L. Tags: Original Research Papers Source Type: research
PML risk stratification using anti-JCV antibody index and L-selectin
Conclusions:
Both JCV index and CD62L have merit for risk stratification and share a potential biological relationship with implications for general PML etiology. A risk algorithm incorporating both biomarkers could strongly reduce PML incidence. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Schwab, N., Schneider-Hohendorf, T., Pignolet, B., Spadaro, M., Görlich, D., Meinl, I., Windhagen, S., Tackenberg, B., Breuer, J., Canto, E., Kümpfel, T., Hohlfeld, R., Siffrin, V., Luessi, F., Posevitz-Fejfar, A., Montalban, X., Meuth, S. Tags: Original Research Papers Source Type: research
Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI
Conclusions:
TSC is not only a sensitive marker of the severity of chronic tissue abnormalities in MS but is also highly sensitive to opening of the blood–brain barrier and vasogenic tissue oedema in contrast-enhancing lesions. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Eisele, P., Konstandin, S., Griebe, M., Szabo, K., Wolf, M. E., Alonso, A., Ebert, A., Serwane, J., Rossmanith, C., Hennerici, M. G., Schad, L. R., Gass, A. Tags: Original Research Papers Source Type: research
Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome
Conclusion:
Infiltration of activated macrophages evidenced by USPIO enhancement, is present at the onset of multiple sclerosis and is associated with higher and persistent local loss of tissue structure. Macrophage infiltration affects more tissue structure while tissue recovery during the following year has a similar pattern for USPIO and Gd-enhanced lesions, leading to relative higher persistent local loss of tissue structure in lesions showing USPIO enhancement at baseline. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Maarouf, A., Ferre, J.-C., Zaaraoui, W., Le Troter, A., Bannier, E., Berry, I., Guye, M., Pierot, L., Barillot, C., Pelletier, J., Tourbah, A., Edan, G., Audoin, B., Ranjeva, J.-P. Tags: Original Research Papers Source Type: research
Vitamin D and axonal injury in multiple sclerosis
Conclusion:
High 25(OH)D levels are associated with decreased axonal injury in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Sandberg, L., Biström, M., Salzer, J., Vagberg, M., Svenningsson, A., Sundström, P. Tags: Original Research Papers Source Type: research
Smoking is a major preventable risk factor for multiple sclerosis
Conclusions:
From a public health perspective, the impact of smoking and passive smoking on MS risk is considerable. Preventive measures in order to reduce tobacco smoke exposure are, therefore, essential. In particular, individuals with a history of MS in the family should be informed regarding the impact of smoking on the risk of MS, and the importance of preventing their children from being exposed to passive smoke. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Hedström, A., Olsson, T., Alfredsson, L. Tags: Original Research Papers Source Type: research
Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis
Conclusion:
Our data suggests a role for ILCs, and in particular the LTi subset, in the early stages of MS. This finding represents an important contribution to the understanding of early inflammation in MS, and adds new knowledge beneficial for future MS therapies. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Degn, M., Modvig, S., Dyring-Andersen, B., Bonefeld, C. M., Frederiksen, J. L., Geisler, C., von Essen, M. R. Tags: Original Research Papers Source Type: research
Progranulin genetic polymorphisms influence progression of disability and relapse recovery in multiple sclerosis
Conclusion:
GRN genetic polymorphisms likely influence disease course and relapse recovery in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Vercellino, M., Fenoglio, C., Galimberti, D., Mattioda, A., Chiavazza, C., Binello, E., Pinessi, L., Giobbe, D., Scarpini, E., Cavalla, P. Tags: Original Research Papers Source Type: research
The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli
Conclusions:
The MS-associated variant rs10877013 is a genetic determinant that affects the functioning of the vitamin D system linking environmental and genetic factors. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Karaky, M., Alcina, A., Fedetz, M., Barrionuevo, C., Potenciano, V., Delgado, C., Izquierdo, G., Matesanz, F. Tags: Original Research Papers Source Type: research
CSF examination still has value in the diagnosis of MS - Commentary
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Arrambide, G., Tintore, M. Tags: Controversies in Multiple Sclerosis Source Type: research
