People with MS should consume a low-salt diet - Commentary
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Pugliatti, M. Tags: Controversies in Multiple Sclerosis Source Type: research
People with MS should consume a low-salt diet - NO
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Ascherio, A., Munger, K. L. Tags: Controversies in Multiple Sclerosis Source Type: research
People with MS should consume a low-salt diet - YES
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Farez, M. F., Correale, J. Tags: Controversies in Multiple Sclerosis Source Type: research
The use of laboratory gait analysis for understanding gait deterioration in people with multiple sclerosis
Laboratory gait analysis or three-dimensional gait analysis (3DGA), which uses motion capture, force plates and electromyography (EMG), has allowed a better understanding of the underlying mechanisms of gait deterioration in patients with multiple sclerosis (PwMS). This review will summarize the current knowledge on multiple sclerosis (MS)-related changes in kinematics (angles), kinetics (forces) and electromyographic (muscle activation) patterns and how these measures can be used as markers of disease progression. We will also discuss the potential causes of slower walking in PwMS and the implications for 3DGA. Finally, w...
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Cofre Lizama, L. E., Khan, F., Lee, P. V., Galea, M. P. Tags: Topical Review Source Type: research
Work status in MS: A proxy measure for comprehensive MS management
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Authors: Playford, E. Tags: Editorial Source Type: research
Corrigendum
Ahmad H, Taylor BV, van der Mei I et al. (2016). The impact of multiple sclerosis severity on health state utility values: Evidence from Australia. Mult Scler. Epub ahead of print. DOI: 10.1177/1352458516672014 (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 8, 2016 Category: Neurology Tags: Corrigendum Source Type: research
Gender identity disorders and multiple sclerosis risk: A national record-linkage study
Conclusion:
We report a strong association between GIDs and MS in male-to-females, supporting a potential role for low testosterone and/or feminising hormones on MS risk in males. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Pakpoor, J., Wotton, C. J., Schmierer, K., Giovannoni, G., Goldacre, M. J. Tags: Short Report Source Type: research
The relationship of age with the clinical phenotype in multiple sclerosis
Conclusions:
Age strongly influences the phenotype before progression. Relapsing-remitting patients younger at onset are more likely to display a predominantly inflammatory course, yet relapses number does not affect the age at onset of progression. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Scalfari, A., Lederer, C., Daumer, M., Nicholas, R., Ebers, G., Muraro, P. Tags: Original Research Papers Source Type: research
Immunomodulatory therapies delay disease progression in multiple sclerosis
Conclusions:
DMDs significantly reduce the risk of multiple sclerosis progression both in patients with initial high-risk and patients with initial low-risk. These findings reinforce the role of DMDs in modifying the natural course of the disease, suggesting that they have a positive effect not only on the inflammatory but also on the neurodegenerative process. The study also confirms the capability of the BREMS score to predict MS evolution. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Bergamaschi, R., Quaglini, S., Tavazzi, E., Amato, M. P., Paolicelli, D., Zipoli, V., Romani, A., Tortorella, C., Portaccio, E., DOnghia, M., Garberi, F., Bargiggia, V., Trojano, M. Tags: Original Research Papers Source Type: research
A serial 10-year follow-up study of brain atrophy and disability progression in RRMS patients
Conclusions:
WB and cortical atrophy, and enlargement of vCSF spaces are associated with development of CDP on serial yearly MRI assessments over a period of 10 years. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Zivadinov, R., Uher, T., Hagemeier, J., Vaneckova, M., Ramasamy, D. P., Tyblova, M., Bergsland, N., Seidl, Z., Dwyer, M. G., Krasensky, J., Havrdova, E., Horakova, D. Tags: Original Research Papers Source Type: research
Depletion of brain functional connectivity enhancement leads to disability progression in multiple sclerosis: A longitudinal resting-state fMRI study
Conclusion:
The study provides two main findings: (1) brain functional connectivity enhancement decreases during the disease course after reaching a maximal level, and (2) decrease in brain functional connectivity enhancement participates in disability progression. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Faivre, A., Robinet, E., Guye, M., Rousseau, C., Maarouf, A., Le Troter, A., Zaaraoui, W., Rico, A., Crespy, L., Soulier, E., Confort-Gouny, S., Pelletier, J., Achard, S., Ranjeva, J.-P., Audoin, B. Tags: Original Research Papers Source Type: research
Perfusion reduction in the absence of structural differences in cognitively impaired versus unimpaired RRMS patients
Conclusion:
Significant cortical CBF and CBV reduction was present in CI compared to NI in the absence of structural differences. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Hojjat, S.-P., Cantrell, C. G., Carroll, T. J., Vitorino, R., Feinstein, A., Zhang, L., Symons, S. P., Morrow, S. A., Lee, L., OConnor, P., Aviv, R. I. Tags: Original Research Papers Source Type: research
Fatigue in multiple sclerosis: The contribution of occult white matter damage
Conclusions:
Fatigue is associated to a widespread microstructural NAWM damage, particularly in associative tracts connected to frontal lobes. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Bisecco, A., Caiazzo, G., dAmbrosio, A., Sacco, R., Bonavita, S., Docimo, R., Cirillo, M., Pagani, E., Filippi, M., Esposito, F., Tedeschi, G., Gallo, A. Tags: Original Research Papers Source Type: research
Hyperconnectivity of the dorsolateral prefrontal cortex following mental effort in multiple sclerosis patients with cognitive fatigue
Conclusion:
The development of cortico–cortical and cortico–subcortical hyperconnectivity following mental effort is related to CF symptoms in MS patients. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Pravata, E., Zecca, C., Sestieri, C., Caulo, M., Riccitelli, G. C., Rocca, M. A., Filippi, M., Cianfoni, A., Gobbi, C. Tags: Original Research Papers Source Type: research
Clinical trials for pediatric MS should be prioritized to test only one or two of the most promising agents - Commentary
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Hintzen, R. Tags: Controversies in Multiple Sclerosis Source Type: research
