CSF examination still has value in the diagnosis of MS - NO
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Killestein, J., Uitdehaag, B. M. Tags: Controversies in Multiple Sclerosis Source Type: research
CSF examination still has value in the diagnosis of MS--YES
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Brundin, L. Tags: Controversies in Multiple Sclerosis Source Type: research
Exploring the overlap between multiple sclerosis, tumefactive demyelination and Balos concentric sclerosis
The availability of magnetic resonance imaging (MRI) has led to increasing recognition that multiple sclerosis (MS), tumefactive demyelination (TD) and Baló’s concentric sclerosis (BCS) share many overlapping features. Baló-like lesions, which exhibit limited features of BCS, may represent an intermediate between BCS and typical MS demyelination. Lesions labeled as tumefactive are typically larger, but otherwise have much in common with conventional MS lesions, and TD and BCS lesions can also overlap. In this article, we explore the similarities between typical MS, TD and BCS cases, and reflect on the p...
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Hardy, T. A., Tobin, W. O., Lucchinetti, C. F. Tags: Topical Review Source Type: research
Declines in the diagnosis of primary progressive MS: A critical change in phenotype or critical measurement error?
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Cutter, G. R., Salter, A., Marrie, R. A. Tags: Editorial Source Type: research
Leptomeningeal enhancement in Susacs syndrome and multiple sclerosis: Time to expect the unexpected?
Magnetic resonance imaging detection of leptomeningeal enhancement has long been considered a red flag for a diagnosis of multiple sclerosis. However, recent studies seem to suggest that leptomeningeal enhancement can be detected in up to 25% of patients with multiple sclerosis. The case reported here suggest a distinct set of features of leptomeningeal enhancement in a patient with Susac’s syndrome which may still be helpful in the differential diagnosis between Susac’s syndrome and multiple sclerosis. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Sastre-Garriga, J. Tags: Clinical Commentary Source Type: research
Susacs syndrome: Leptomeningeal enhancement on 3D FLAIR MRI
Conclusion:
Ce 3D FLAIR may aid in diagnosis and understanding of pathophysiology in Susac’s syndrome and may serve as a biomarker for disease activity. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Engisch, R., Titelbaum, D. S., Chilver-Stainer, L., Kellner-Weldon, F. Tags: Case Reports Source Type: research
Extensive molluscum contagiosum virus infection in a young adult receiving fingolimod
Fingolimod-related viral infections have been described on several occasions since its introduction in 2010. We hereby add a report on an otherwise immunocompetent, 18-year old Caucasian man with relapsing-remitting multiple sclerosis who developed a protracted and extensive molluscum contagiosum (MC) virus infection shortly after being started on fingolimod. Wide-spread cutaneous MC infections in adult patients are considered indicative of underlying immunosuppression. Neurologists prescribing fingolimod ought to be aware of a possibly increased risk of MC, but also need to know about its relative benignity, lack of extra...
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Behle, V., Wobser, M., Goebeler, M., Stoevesandt, J. Tags: Case Reports Source Type: research
The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients
Conclusions:
Anti-MOG positive patients may have manifestations that mimic NMOSD but differ in their course and prognosis from anti-AQP4 positive NMOSD. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Siritho, S., Sato, D. K., Kaneko, K., Fujihara, K., Prayoonwiwat, N. Tags: Short Reports Source Type: research
Spinal cord involvement in Behcets disease
Conclusions:
Longitudinally extensive transverse myelitis is a characteristic manifestation of spinal cord involvement in Behcet’s disease. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Lee, H. S., Kim, D. Y., Shin, H. Y., Choi, Y.-C., Kim, S. M. Tags: Short Reports Source Type: research
Efficacy of rituximab in refractory neuromyelitis optica
Conclusions:
RTX is an effective and well-tolerated treatment in RNMO. BMI could be a predictive factor for efficacy. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Collongues, N., Brassat, D., Maillart, E., Labauge, P., Ouallet, J., Carra-Dalliere, C., Moreau, T., Bourre, B., Papeix, C., Brochet, B., Audoin, B., Vukusic, S., de Seze, J., Marignier, R., on behalf of the OFSEP and CFSEP Tags: Short Reports Source Type: research
Improved patient-reported health impact of multiple sclerosis: The ENABLE study of PR-fampridine
Conclusion:
PR-fampridine improved patient-perceived physical and psychological health impact of MS measured in a real-life setting. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Macdonell, R., Nagels, G., Laplaud, D.-A., Pozzilli, C., de Jong, B., Martins da Silva, A., Nicholas, R., Lechner-Scott, J., Gaebler, J. A., Agarwal, S., Wang, P., Yeh, M., Hovenden, M., Soelberg Sorensen, P. Tags: Original Research Papers Source Type: research
Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort
Conclusions:
We observed a possible worsening of MS disability after menopause. Larger cohorts are required to assess any HRT effects. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Bove, R., Healy, B. C., Musallam, A., Glanz, B. I., De Jager, P. L., Chitnis, T. Tags: Original Research Papers Source Type: research
Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis
Conclusion:
Monthly methylprednisolone pulse treatment was safe, but had no effect on the primary outcome. However, improvements in secondary clinical and MRI outcome measures suggest that this treatment regimen may have a beneficial effect in progressive MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Ratzer, R., Iversen, P., Börnsen, L., Dyrby, T. B., Romme Christensen, J., Ammitzboll, C., Madsen, C. G., Garde, E., Lyksborg, M., Andersen, B., Hyldstrup, L., Sorensen, P. S., Siebner, H. R., Sellebjerg, F. Tags: Original Research Papers Source Type: research
Lymphocytosis as a response biomarker of natalizumab therapeutic efficacy in multiple sclerosis
Conclusions:
We suggest that NIL could be a biomarker of therapeutic efficacy in patients with RRMS treated with natalizumab, and that the risk of relapse may be higher in patients with a lower-than-expected NIL. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Signoriello, E., Lanzillo, R., Brescia Morra, V., Di Iorio, G., Fratta, M., Carotenuto, A., Lus, G. Tags: Original Research Papers Source Type: research
Grey matter involvement by focal cervical spinal cord lesions is associated with progressive multiple sclerosis
Conclusions:
More extensive focal cord lesions, extension of lesions to GM, and diffuse abnormalities are associated with progressive MS and disability. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Kearney, H., Miszkiel, K. A., Yiannakas, M. C., Altmann, D. R., Ciccarelli, O., Miller, D. H. Tags: Original Research Papers Source Type: research
