Cerebrospinal fluid neurofilament light chain levels predict visual outcome after optic neuritis
Conclusion:
CSF NF-L is a promising biomarker of visual outcome after optic neuritis. This could aid neuroprotective/regenerative medical advancements. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Modvig, S., Degn, M., Sander, B., Horwitz, H., Wanscher, B., Sellebjerg, F., Frederiksen, J. Tags: Original Research Papers Source Type: research
Can we define a rehabilitation strategy for cognitive impairment in progressive multiple sclerosis? A critical appraisal
Cognitive impairment (CI) has been shown to be severe in patients with progressive forms of multiple sclerosis (MS), and the most frequently impaired domains are sustained attention, information processing speed, memory, and executive functions. In contrast to relapsing forms of MS, where studies have shown favorable results from cognitive rehabilitation, there is a lack of data on cognitive rehabilitation in progressive forms of MS. A specific approach in assessing CI and in designing and administering rehabilitation training for patients with progressive forms of MS is needed. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: DAmico, E., Leone, C., Hayrettin, T., Patti, F. Tags: Topical Review Source Type: research
Intractable cough as characteristic symptom of neuromyelitis optica and neuromyelitis optica spectrum disorder
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Fujita-Nakata, M., Tomioka, R., Tanaka, K., Nakanishi, M., Nagayama, S., Takahashi, R., Machiya, T., Hamada, T., Matsui, M. Tags: Letters to the Editor Source Type: research
Is there a cognitive signature for MS-related fatigue? Response to Feinstein
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Hanken, K., Eling, P., Hildebrandt, H. Tags: Letters to the Editor Source Type: research
Stable neuropsychiatric status in multiple sclerosis: a 3-year study
This study assessed personality traits and neuropsychiatric symptoms over 3 years using the NEO Five Factor Inventory and the Neuropsychiatric Inventory. Additional metrics evaluated ambulation, manual dexterity and cognitive function. Contrary to hypothesis, patients showed no significant change in personality or neuropsychiatric status relative to controls. Patients were impaired in motor and cognitive function at baseline and follow-up, but showed only slowing in ambulation over time. The findings indicate that neuropsychiatric status is stable in MS over 3 years. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Roy, S., Rodgers, J., Drake, A. S., Zivadinov, R., Weinstock-Guttman, B., Benedict, R. H. Tags: Short Reports Source Type: research
Pituitary-ovary axis and ovarian reserve in fertile women with multiple sclerosis: A pilot study
Since a decline in the ovary function might impact the reproductive potential in women with multiple sclerosis (MS), we investigated the pituitary-ovary axis and ovarian reserve, including anti-Müllerian hormone (AMH) levels and ultrasound imaging of the ovaries, of 25 relapsing–remitting MS patients and 25 age-matched healthy controls. Mean levels of pituitary-gonadal hormones and age-adjusted parameters of ovarian reserve markers were not significantly different between both groups. Patients with higher disease activity (annualized relapse rate >0.5; n=9) had significantly lower AMH levels, total antral ...
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Sepulveda, M., Ros, C., Martinez-Lapiscina, E. H., Sola-Valls, N., Hervas, M., Llufriu, S., La Puma, D., Casals, E., Blanco, Y., Villoslada, P., Graus, F., Castelo-Branco, C., Saiz, A. Tags: Short Reports Source Type: research
Why does multiple sclerosis only affect human primates?
Background:
Multiple sclerosis (MS) develops exclusively in humans. Non-human primates are resistant against MS, although they are highly susceptible to the MS animal model, experimental autoimmune encephalomyelitis (EAE). Unravelling of the cause(s) underlying this discrepancy is highly relevant as insights might be gained into the elusive event(s) that trigger(s) MS. A well-established difference between the human primate (Homo sapiens) and non-human primates is that humans are unable to synthesize the sialic acid N-glycolylneuraminic acid (Neu5Gc).
Viewpoint:
We propose the concept that long-term ingestion by human pri...
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: 't Hart, B. A. Tags: Personal Viewpoint Source Type: research
Personality traits predict perceived health-related quality of life in persons with multiple sclerosis
Conclusions:
Our data confirm that PwMS’ HRQoL is largely influenced by personality traits, which may therefore act as predictors of perceived quality of life and should be included in clinical and experimental settings focusing on HRQoL. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Zarbo, I. R., Minacapelli, E., Falautano, M., Demontis, S., Carpentras, G., Pugliatti, M. Tags: Original Research Papers Source Type: research
Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and performance of everyday life tasks: Actual Reality
Conclusions:
Individuals with MS have greater problems with actual everyday life tasks as compared to HC. The BICAMS is a promising cognitive screening tool to predict actual functional performance in participants with MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Goverover, Y., Chiaravalloti, N., DeLuca, J. Tags: Original Research Papers Source Type: research
A 10-year follow-up of the European multicenter trial of interferon {beta}-1b in secondary-progressive multiple sclerosis
Conclusions:
The results from this analysis did not provide convincing evidence to support a favorable long-term outcome in those patients allocated IFNB-1b during the RCT, in our SPMS cohort. The progressive stage of the disease remains largely unpredictable by clinical and conventional MRI measures, so better prognostic markers are needed. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Kuhle, J., Hardmeier, M., Disanto, G., Gugleta, K., Ecsedi, M., Lienert, C., Amato, M., Baum, K., Buttmann, M., Bayas, A., Brassat, D., Brochet, B., Confavreux, C., Edan, G., Färkkilä, M., Fredrikson, S., Frontoni, M., DHooghe, M., Hutchin Tags: Original Research Papers Source Type: research
The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis
Conclusion:
Following the availability of fingolimod, patients were more likely to discontinue injectable treatments. Those who switched to fingolimod were more likely to do so for convenience. Persistence was improved on fingolimod compared to other medications. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Warrender-Sparkes, M., Spelman, T., Izquierdo, G., Trojano, M., Lugaresi, A., GrandMaison, F., Havrdova, E., Horakova, D., Boz, C., Oreja-Guevara, C., Alroughani, R., Iuliano, G., Duquette, P., Girard, M., Terzi, M., Hupperts, R., Grammond, P., Petersen, Tags: Original Research Papers Source Type: research
Neuromyelitis optica spectrum disorders: long-term safety and efficacy of rituximab in Caucasian patients
Conclusions:
A fixed treatment scheme of rituximab, with re-treatment every 6 months, was efficacious for NMO and NMOSD, with a good safety profile; however, to obtain an even better benefit-risk ratio, close monitoring of CD19+ B cells should be performed before the re-treatment of patients with high-level disability, concomitant leukopenia and hypogammaglobulinemia. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Radaelli, M., Moiola, L., Sangalli, F., Esposito, F., Barcella, V., Ferre, L., Rodegher, M., Colombo, B., Fazio, R., Martinelli, V., Comi, G. Tags: Original Research Papers Source Type: research
Validation of kappa free light chains as a diagnostic biomarker in multiple sclerosis and clinically isolated syndrome: A multicenter study
Conclusion:
These findings further support the diagnostic value of intrathecal KFLC synthesis in CIS and MS patients and demonstrate a valid, easier and rater-independent alternative to OCB detection. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Presslauer, S., Milosavljevic, D., Huebl, W., Aboulenein-Djamshidian, F., Krugluger, W., Deisenhammer, F., Senel, M., Tumani, H., Hegen, H. Tags: Original Research Papers Source Type: research
MRI-detectable cortical lesions in the cerebellum and their clinical relevance in multiple sclerosis
Conclusions:
CL are detected by PSIR in the cerebellum of the majority of MS patients, are more than WML, increase with disease progression and strongly correlate with the cerebellar EDSS. Thus, the observation of CL in the cerebellum of MS at clinical onset might be useful for prognostic and therapeutic aims. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Favaretto, A., Lazzarotto, A., Poggiali, D., Rolma, G., Causin, F., Rinaldi, F., Perini, P., Gallo, P. Tags: Original Research Papers Source Type: research
Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression
Conclusion:
The diagnostic and prognostic accuracy of autoimmune neuroinflammatory diseases can be improved by FACS analysis of CSF cells. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Nemecek, A., Zimmermann, H., Rübenthaler, J., Fleischer, V., Paterka, M., Luessi, F., Müller-Forell, W., Zipp, F., Siffrin, V. Tags: Original Research Papers Source Type: research
