False positivity of anti aquaporin-4 antibodies in natalizumab-treated patients
Conclusions:
Clinicians should be aware of potential technical issues in detecting AQP4-Ab in NTZ-treated patients leading to false positive results. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Cohen, M., De Seze, J., Marignier, R., Lebrun, C. Tags: Case Reports Source Type: research
Prevalence of neuropathic pain in early multiple sclerosis
Conclusions:
Neuropathic pain appears to be less frequent in early multiple sclerosis than expected and is significantly associated with disability, depression and fatigue. The assessment and therapy of pain in multiple sclerosis should thus take into account neuropsychiatric symptoms already at early disease stages. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Heitmann, H., Biberacher, V., Tiemann, L., Buck, D., Loleit, V., Selter, R. C., Knier, B., Tölle, T. R., Mühlau, M., Berthele, A., Hemmer, B., Ploner, M. Tags: Original Research Papers Source Type: research
Alemtuzumab for multiple sclerosis: Long term follow-up in a multi-centre cohort
Conclusion:
Observed reduction in relapse rates reflected those reported in clinical trials, but we were unable to corroborate previous observations of disability reversal. 40% of patients required additional treatment cycles. Autoimmune adverse events were common, occurring at a higher rate than previously reported, but were largely predictable, and could be managed effectively within a rigorous monitoring regime. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Willis, M., Harding, K., Pickersgill, T., Wardle, M., Pearson, O., Scolding, N., Smee, J., Robertson, N. Tags: July 2016 22 (8) Original Research Papers Source Type: research
Deregulation of microRNA-181c in cerebrospinal fluid of patients with clinically isolated syndrome is associated with early conversion to relapsing-remitting multiple sclerosis
Conclusions:
Cerebrospinal fluid miRNA-181c might serve as a biomarker for early conversion to RRMS. Moreover, our data suggest an intrathecal origin of microRNAs detected in the cerebrospinal fluid. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Ahlbrecht, J., Martino, F., Pul, R., Skripuletz, T., Sühs, K.-W., Schauerte, C., Yildiz, O., Trebst, C., Tasto, L., Thum, S., Pfanne, A., Roesler, R., Lauda, F., Hecker, M., Zettl, U. K., Tumani, H., Thum, T., Stangel, M. Tags: July 2016 22 (8) Original Research Papers Source Type: research
Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study
Conclusions:
AQP4-IgG1 antibodies are present in the sera years before the first NMO attack in patients with SLE; elevation of anti-AQP4 is part of a polyclonal B cell response during NMO relapses; in spite of multiple autoantibodies in the serum, MOG antibodies were not present; Th1 responses accompany autoantibody responses in NMO/SLE. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Kovacs, K. T., Kalluri, S. R., Boza-Serrano, A., Deierborg, T., Csepany, T., Simo, M., Rokusz, L., Miseta, A., Alcaraz, N., Czirjak, L., Berki, T., Molnar, T., Hemmer, B., Illes, Z. Tags: Original Research Papers Source Type: research
Cortical relapses in multiple sclerosis
Conclusions:
Cortical relapses may occur in MS. MRI examination in MS should include sequences, such as double inversion recovery (DIR) or phase sensitive inversion recovery (PSIR), that are aimed at visualizing cortical lesions, especially in the presence of symptoms of cortical dysfunction. Our observation further stresses and extends the clinical relevance of cortical pathology in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Puthenparampil, M., Poggiali, D., Causin, F., Rolma, G., Rinaldi, F., Perini, P., Gallo, P. Tags: July 2016 22 (8) Original Research Papers Source Type: research
Diagnostic performance of brain MRI in pharmacovigilance of natalizumab-treated MS patients
Conclusion:
The diagnostic performance of trained neuroradiologists using brain MRI in pharmacovigilance of natalizumab-treated MS patients is moderately good. Interrater agreement among trained readers is fair to moderate. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Wattjes, M. P., Wijburg, M. T., Vennegoor, A., Witte, B. I., Roosendaal, S. D., Sanchez, E., Liu, Y., Martins Jarnalo, C. O., Richert, N. D., Uitdehaag, B. M., Barkhof, F., Killestein, J. Tags: July 2016 22 (8) Original Research Papers Source Type: research
No evidence for an effect on brain atrophy rate of atorvastatin add-on to interferon {beta}1b therapy in relapsing-remitting multiple sclerosis (the ARIANNA study)
Conclusions:
Our results suggest that the combination of atorvastatin and interferon β1b is not justified in early relapsing–remitting multiple sclerosis and adds to the body of evidence indicating an absence of significant radiological and clinical benefit of statins in relapsing–remitting multiple sclerosis. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Lanzillo, R., Quarantelli, M., Pozzilli, C., Trojano, M., Amato, M. P., Marrosu, M. G., Francia, A., Florio, C., Orefice, G., Tedeschi, G., Bellantonio, P., Annunziata, P., Grimaldi, L. M., Comerci, M., Brunetti, A., Bonavita, V., Alfano, B., Marini, S., Tags: Original Research Papers Source Type: research
Elevated CSF neurofilament proteins predict brain atrophy: A 15-year follow-up study
Conclusion:
These data suggest that high CSF NfH levels are an early predictor of later brain and spinal cord atrophy using structural imaging biomarkers and can be investigated in reasonably sized patient cohorts. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Petzold, A., Steenwijk, M. D., Eikelenboom, J. M., Wattjes, M. P., Uitdehaag, B. M. Tags: Original Research Papers Source Type: research
Abnormal adaptation over time of motor network recruitment in multiple sclerosis patients with fatigue
Conclusions:
Abnormalities and impaired timing of activation between different areas of the motor and executive networks occur in F-MS patients. The dysfunction of critical cortical areas contributes to the occurrence of central fatigue. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Rocca, M. A., Meani, A., Riccitelli, G. C., Colombo, B., Rodegher, M., Falini, A., Comi, G., Filippi, M. Tags: Original Research Papers Source Type: research
Spin echo transverse relaxation and atrophy in multiple sclerosis deep gray matter: A two-year longitudinal study
Conclusions:
Two-year difference R2 measurements in DGM correlate to disease severity in MS. R2 mapping and atrophy measurements over two years can be used to identify changes in DGM in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Uddin, M. N., Lebel, R. M., Seres, P., Blevins, G., Wilman, A. H. Tags: Original Research Papers Source Type: research
Integrated multidisciplinary clinics should be the gold standard in managing progressive MS - Commentary
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Hutchinson, M. Tags: Controversies in multiple sclerosis: a new series of debates Source Type: research
Integrated multidisciplinary clinics should be the gold standard in managing progressive MS - NO
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Papeix, C., Lubetzki, C. Tags: Controversies in multiple sclerosis: a new series of debates Source Type: research
Integrated multidisciplinary clinics should be the gold standard in managing progressive MS - YES
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Uygunoglu, U., Kantarci, O., Siva, A. Tags: Controversies in multiple sclerosis: a new series of debates Source Type: research
Astrocytes in multiple sclerosis
Recent experimental and clinical studies on astrocytes are unraveling the capabilities of these multi-functional cells in normal homeostasis, and in central nervous system (CNS) disease. This review focuses on understanding their behavior in all aspects of the initiation, evolution, and resolution of the multiple sclerosis (MS) lesion. Astrocytes display remarkable flexibility and variability of their physical structure and biochemical output, each aspect finely tuned to the specific stage and location of the disease, participating in both pathogenic and beneficial changes seen in acute and progressive forms. As examples, ...
Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Ludwin, S. K., Rao, V. T., Moore, C. S., Antel, J. P. Tags: Topical Reviews Source Type: research
