Cerebrospinal fluid lipocalin 2 in patients with clinically isolated syndromes and early multiple sclerosis
Conclusion:
We demonstrate altered LCN2 regulation in early MS and provide first evidence for this to be possibly linked to both clinical MS activity and iron accumulation in the basal ganglia. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Khalil, M., Renner, A., Langkammer, C., Enzinger, C., Ropele, S., Stojakovic, T., Scharnagl, H., Bachmaier, G., Pichler, A., Archelos, J., Fuchs, S., Seifert-Held, T., Fazekas, F. Tags: Original Research Papers Source Type: research
Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity
Conclusion:
CSF and serum NfL levels were highly correlated, and serum concentrations were increased in RRMS. Serum NfL levels correlated with MRI markers of WM disease severity. Our findings further support longitudinal studies of serum NfL as a potential biomarker of on-going disease progression and as a potential surrogate to quantify effects of neuroprotective drugs in clinical trials. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Kuhle, J., Barro, C., Disanto, G., Mathias, A., Soneson, C., Bonnier, G., Yaldizli, O., Regeniter, A., Derfuss, T., Canales, M., Schluep, M., Du Pasquier, R., Krueger, G., Granziera, C. Tags: Original Research Papers Source Type: research
Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis and brain biopsy findings in a MOG-IgG-positive case
Conclusion:
This is the largest study on established anti-neural antibodies performed in MS so far. MOG-IgG may play a role in a small percentage of patients diagnosed with pattern II MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Jarius, S., Metz, I., König, F. B., Ruprecht, K., Reindl, M., Paul, F., Brück, W., Wildemann, B. Tags: Original Research Papers Source Type: research
European multiple sclerosis risk variants in the south Asian population
Conclusion:
Our data indicate substantial overlap in genetic risk architecture between Europeans and south Asians and suggest that the aetiology of the disease may be largely independent of ethnicity. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Pandit, L., Ban, M., Beecham, A. H., McCauley, J. L., Sawcer, S., DCunha, A., Malli, C., Malik, O. Tags: Original Research Papers Source Type: research
Genetic predictors of relapse rate in pediatric MS
Conclusion:
We demonstrate that HLA-DRB1*15 modifies the association of vitamin D status with relapse rate. Our findings emphasize the need to pursue disease-modifying effects of MS genes in the context of environmental factors. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Graves, J. S., Barcellos, L. F., Shao, X., Noble, J., Mowry, E. M., Quach, H., Belman, A., Casper, T. C., Krupp, L. B., Waubant, E., on behalf of the U.S. Network of Pediatric MS Centers Tags: Original Research Papers Source Type: research
Brain atrophy measurements should be used to guide therapy monitoring in MS - Commentary
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Chard, D. Tags: Controversies in Multiple Sclerosis Source Type: research
Brain atrophy measurements should be used to guide therapy monitoring in MS - NO
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Barkhof, F. Tags: Controversies in Multiple Sclerosis Source Type: research
Brain atrophy measurements should be used to guide therapy monitoring in MS - YES
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Zivadinov, R., Dwyer, M. G., Bergsland, N. Tags: Controversies in Multiple Sclerosis Source Type: research
Radiologically isolated syndrome: An update on a rare entity
Our understanding of radiologically isolated syndrome (RIS) is evolving, as new data emerge on the clinical characterization and the pathophysiological nature of this rare entity. This topical review aims to (1) outline state-of-the-art clinical and magnetic resonance imaging findings of RIS research; (2) raise the main obstacles to RIS research; (3) discuss the most controversial issues of current RIS findings; and (4) highlight potential strategies for upcoming research studies. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Labiano-Fontcuberta, A., Benito-Leon, J. Tags: Topical Review Source Type: research
Lubrini et al.s study, "The contribution of depressive symptoms to slowness of information processing in relapsing remitting multiple sclerosis"
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Arnett, P. Tags: Editorial Source Type: research
Erratum
Sbardella E, Tona F, Petsas N, et al. Functional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal 2015; 21(13): 1681–1692. DOI: 10.1177/1352458514568826
The above article that appeared in the November 2015 issue of Multiple Sclerosis Journal contained incorrect affiliations for two of the authors.
The correct affiliation for Patrizia Pantano is Department of Neurology and Psychiatry, University of Rome, Italy / IRCSS Neuromed, Italy.
The correct affiliation for Nicola Filippini is F...
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Tags: Erratum Source Type: research
Erratum
In the article The use of gaming technology for rehabilitation in people with multiple sclerosis, DOI: 10.1177/1352458514563593, published in Multiple Sclerosis Volume 21 Issue 4, Table 1 was printed incorrectly. The corrected Table 1 is below:
Table 1.Exergaming studies.
Ref.PlatformParticipants and interventionOutcomesPlow and Finlayson31WiiPre-test vs. post-test repeated measures home-based Wii training. Participants: N=30, age 43.2 ± 9.3 years, 9 ± 6.8 years since diagnosis. Intervention: 3 x per week programme consisting of yoga, balance, strength, and aerobic training in each session. Wii playing minu...
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Tags: Erratum Source Type: research
Corrigendum
Cree BC, Bennett JL, Sheehan M et al. (2016). Placebo-controlled study in neuromyelitis optica—Ethical and design considerations. Mult Scler 22(7) 862–872. DOI: 10.1177/1352458515620934 (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Tags: Corrigendum Source Type: research
Corrigendum
to Ragheb, S et al. (2011). Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid Multiple Sclerosis Journal. 17(07) 819–829. [DOI: 10.1177/1352458511398887]. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Tags: Corrigendum Source Type: research
Corrigendum
to Munger, KL and Ascherio A. (2011). Prevention and treatment of MS: studying the effects of vitamin D Multiple Sclerosis Journal. 17(12) 1405–1411. [DOI:10.1177/1352458511425366]. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Tags: Corrigendum Source Type: research
