Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: Clinical and prognostic implications
Conclusion:
Patients with MOG-abs in AQP4-ab seronegative LETM have clinical distinctive features, higher risk of optic neuritis relapses, and better outcome than patients seronegative. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Cobo-Calvo, A., Sepulveda, M., Bernard-Valnet, R., Ruiz, A., Brassat, D., Martinez-Yelamos, S., Saiz, A., Marignier, R. Tags: Original Research Papers Source Type: research
Differentiating neuromyelitis optica from other causes of longitudinally extensive transverse myelitis on spinal magnetic resonance imaging
Conclusions:
Certain spinal cord MRI features are more commonly seen in NMO patients and so obtaining brain MRI during LETM may support diagnosis. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Pekcevik, Y., Mitchell, C. H., Mealy, M. A., Orman, G., Lee, I. H., Newsome, S. D., Thompson, C. B., Pardo, C. A., Calabresi, P. A., Levy, M., Izbudak, I. Tags: Original Research Papers Source Type: research
Abnormal cerebellar functional MRI connectivity in patients with paediatric multiple sclerosis
Conclusions:
Modifications of cerebellar RSFC occur in paediatric MS and are influenced by the duration of the disease and brain focal lesions. Decreased RSFC may reflect early maladaptive plasticity contributing to cognitive impairment. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Cirillo, S., Rocca, M. A., Ghezzi, A., Valsasina, P., Moiola, L., Veggiotti, P., Amato, M. P., Comi, G., Falini, A., Filippi, M. Tags: Original Research Papers Source Type: research
Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins
Conclusions:
Enhanced intrathecal autoBLCL-specific T-cell reactivity, selectively directed towards lytic EBV proteins in two CSF-TCL, suggested a localized T-cell response to EBV in patients with MS. Our data warrant further characterization of the magnitude and breadth of intrathecal EBV-specific T-cell responses in larger patient cohorts. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: van Nierop, G. P., Mautner, J., Mitterreiter, J. G., Hintzen, R. Q., Verjans, G. M. Tags: Original Research Papers Source Type: research
Longitudinal fMRI studies: Exploring brain plasticity and repair in MS
Functional magnetic resonance imaging (fMRI) has greatly advanced our understanding of cerebral functional changes occurring in patients with multiple sclerosis (MS). However, most of our knowledge regarding brain plasticity and repair in MS as evidenced by fMRI has been extrapolated from cross-sectional studies across different phenotypes of the disease. This topical review provides an overview of this research, but also highlights limitations of existing fMRI studies with cross-sectional design. We then review the few existing longitudinal fMRI studies and discuss the feasibility and constraints of serial fMRI in individ...
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Enzinger, C., Pinter, D., Rocca, M. A., De Luca, J., Sastre-Garriga, J., Audoin, B., Filippi, M. Tags: Topical Review Source Type: research
Tribute to John F. Kurtzke, MD, FACP, FAAN: 1926-2015
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Bever, C. T., Wallin, M. T. Tags: Obituary Source Type: research
Potential of robot-assisted therapy for disabled persons with MS
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Feys, P. Tags: Editorial Source Type: research
Author Index
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 1, 2016 Category: Neurology Tags: Articles Source Type: research
ACTRIMS Forum 2016
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 1, 2016 Category: Neurology Tags: Articles Source Type: research
Contents
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 1, 2016 Category: Neurology Tags: Articles Source Type: research
Tocilizumab and multiple sclerosis: a causal relationship? Clinical Commentary on the case report entitled - MS arising during Tocilizumab therapy for rheumatoid arthritis
This clinical commentary discusses on the potential relationship between multiple sclerosis (MS) and tocilizumab in a patient with rheumatoid arthritis who developed MS while on treatment with this anti-interleukin-6 agent. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Comabella, M. Tags: Case Report and Clinical Commentary Source Type: research
MS arising during Tocilizumab therapy for rheumatoid arthritis
Conclusion:
This case illustrates that Tocilizumab might cause secondary auto-immunity in CNS. It is important to be aware of this potential complication as anti-IL6 therapy might become an option for the treatment NMOSD. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Beauchemin, P., Carruthers, R. Tags: Case Report and Clinical Commentary Source Type: research
A comparison study of cognitive deficits in radiologically and clinically isolated syndromes
Conclusions:
The prevalence of cognitive deficits in RIS was similar to that of CIS. Cognitive deficits seem to be present in RIS patients regardless of the presence of risk factors for a future symptomatic demyelinating event. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Labiano-Fontcuberta, A., Martinez-Gines, M. L., Aladro, Y., Ayuso, L., Mitchell, A. J., Puertas-Martin, V., Cerezo, M., Higueras, Y., Benito-Leon, J. Tags: Short Reports Source Type: research
Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis
Conclusion:
Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Fainardi, E., Bortolotti, D., Bolzani, S., Castellazzi, M., Tamborino, C., Roversi, G., Baldi, E., Caniatti, M. L., Casetta, I., Gentili, V., Granieri, E., Rizzo, R., the ERMES study group, Granieri, Castellazzi, Casetta, Tola, Fainardi, Dallocchio, Belli Tags: Short Reports Source Type: research
In multiple sclerosis anxiety, not depression, is related to gender
Conclusion:
In MS, gender influences the frequency of anxiety only. This suggests that the etiological factors underpinning anxiety and depression in MS are not only different from one another, but also in the case of depression, different from those observed in general population samples. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Theaudin, M., Romero, K., Feinstein, A. Tags: Original Research Papers Source Type: research
