Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins

Conclusions:
Enhanced intrathecal autoBLCL-specific T-cell reactivity, selectively directed towards lytic EBV proteins in two CSF-TCL, suggested a localized T-cell response to EBV in patients with MS. Our data warrant further characterization of the magnitude and breadth of intrathecal EBV-specific T-cell responses in larger patient cohorts.

Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: van Nierop, G. P., Mautner, J., Mitterreiter, J. G., Hintzen, R. Q., Verjans, G. M. Tags: Original Research Papers Source Type: research