Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study
Conclusions:
This multicenter study showed mild global cortical thinning in RRMS. The extent of thinning is less pronounced than previously reported. Only subtle regional differences between CI and CP patients were observed, some of which related to specific cognitive domains. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Tillema, J., Hulst, H., Rocca, M., Vrenken, H., Steenwijk, M., Damjanovic, D., Enzinger, C., Ropele, S., Tedeschi, G., Gallo, A., Ciccarelli, O., Rovira, A., Montalban, X., de Stefano, N., Stromillo, M., Filippi, M., Barkhof, F., on behalf of the MAGNIMS Tags: Original Research Papers Source Type: research
Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination
Conclusion:
Patients with radiologically and clinically isolated syndromes behave similarly concerning paraclinical disease activity in cerebral magnetic resonance imaging. In both conditions, reduction of retinal nerve fibre layer and increased inner nuclear layer and outer nuclear layer volumes predict disease activity and are associated with progression into multiple sclerosis. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Knier, B., Berthele, A., Buck, D., Schmidt, P., Zimmer, C., Mühlau, M., Hemmer, B., Korn, T. Tags: Original Research Papers Source Type: research
Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study
Conclusions:
There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Hoare, S., Lithander, F., van der Mei, I., Ponsonby, A.-L., Lucas, R., for the Ausimmune Investigator Group, Chapman, Coulthard, Dear, Dwyer, Kilpatrick, Lucas, McMichael, Pender, Ponsonby, Taylor, Valery, van der Mei, Williams Tags: Original Research Papers Source Type: research
Body mass index during adolescence, rather than childhood, is critical in determining MS risk
Conclusions:
Our results suggest that BMI during adolescence, rather than childhood, is critical in determining MS risk. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Hedström, A., Olsson, T., Alfredsson, L. Tags: Original Research Papers Source Type: research
All relapsing multiple sclerosis patients should be managed at a specialist clinic - Commentary
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Hutchinson, M. Tags: Controversies in Multiple Sclerosis Source Type: research
All relapsing multiple sclerosis patients should be seen in specialist clinics - NO
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Brenner, R. Tags: Controversies in Multiple Sclerosis Source Type: research
All relapsing multiple sclerosis patients should be managed at a specialist clinic - YES
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Brownlee, W. J., Ciccarelli, O. Tags: Controversies in Multiple Sclerosis Source Type: research
Placebo-controlled study in neuromyelitis optica--Ethical and design considerations
Conclusion:
The approach we took in the design of the N-MOmentum trial might serve as a roadmap for other rare severe diseases when there is no proven therapy and no established clinical development path. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Cree, B. A., Bennett, J. L., Sheehan, M., Cohen, J., Hartung, H.-P., Aktas, O., Kim, H. J., Paul, F., Pittock, S., Weinshenker, B., Wingerchuk, D., Fujihara, K., Cutter, G., Patra, K., Flor, A., Barron, G., Madani, S., Ratchford, J. N., Katz, E. Tags: Future Perspectives Source Type: research
Urinary tract infections in multiple sclerosis
Conclusion:
This review provides an overview of the diagnosis, treatment and prevention of UTIs in the setting of multiple sclerosis (MS). (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Phe, V., Pakzad, M., Curtis, C., Porter, B., Haslam, C., Chataway, J., Panicker, J. N. Tags: Topical Review Source Type: research
The N-MOmentum trial: Building momentum to advance trial methodology in a rare disease
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - June 1, 2016 Category: Neurology Authors: Chataway, J., Friede, T. Tags: Editorial Source Type: research
Cardiac stunning as first manifestation of multiple sclerosis: A case report reminding us not to overlook cardiovascular autonomic dysfunction in multiple sclerosis
Autonomic dysfunction is common but frequently overlooked in multiple sclerosis (MS) patients. The case of a Tako-Tsubo cardiomyopathy on which this commentary is based shows that centrally triggered autonomic dysfunction may be the first life-threatening manifestation of MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Hilz, M. J. Tags: Case Report and Clinical Commentary Source Type: research
An uncommon first manifestation of multiple sclerosis: Tako-Tsubo cardiomyopathy
Conclusions:
Clinicians should consider a possible neurological origin of TTC, and according to the clinical characteristics of the patient, MS may be suspected. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Midaglia, L., Juega Marino, J. M., Sastre-Garriga, J., Rovira, A., Vidal-Jordana, A., Lopez-Perez, M. A., Marzo-Sola, M. E., Librada Escribano, F., Montalban, X. Tags: Case Report and Clinical Commentary Source Type: research
Validating Neuro-QoL short forms and targeted scales with people who have multiple sclerosis
Conclusions:
The Neuro-QOL SFs demonstrate good internal consistency, test-re-test reliability, and concurrent and known groups validity in this MS population, supporting the validity of Neuro-QOL in adults with MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Miller, D. M., Bethoux, F., Victorson, D., Nowinski, C. J., Buono, S., Lai, J.-S., Wortman, K., Burns, J. L., Moy, C., Cella, D. Tags: Original Research Papers Source Type: research
Atrophy of reward-related striatal structures in fatigued MS patients is independent of physical disability
Conclusions:
Fatigued MS patients have a global cortical and subcortical gray-matter atrophy that seems largely related to higher physical disability. However, striatal structures involved in effort-reward functions exhibited smaller volumes in fatigued patients, independently of physical disability and depressive symptoms, supporting the theory of cortico-striatal network impairment in MS fatigue. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Damasceno, A., Damasceno, B. P., Cendes, F. Tags: Original Research Papers Source Type: research
Pixantrone: a B-cell-depleting immunosuppressant for multiple sclerosis patients with active disease
Conclusion:
These preliminary data indicate the efficacy of PIX in active RRMS and SPMS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Gonsette, R., Debouverie, M., Sindic, C., Ferre, J.-C., Edan, G. Tags: Original Research Papers Source Type: research
